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The influence of stimulating electrode conditions on electrically evoked potentials and resistance in suprachoroidal transretinal stimulation

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Abstract

Purpose

To determine the influence of stimulating electrode conditions on the amplitudes and latencies of electrically evoked potentials (EEPs) and the resistance at the electrode–tissue interface in the suprachoroidal transretinal stimulation (STS) system.

Study design

Experimental study.

Methods

A scleral pocket (3 × 5 mm) was created just over the visual streak in anesthetized pigmented rabbits (weight, 1.9-2.7 kg), and STS stimulating electrodes were implanted into the pocket. Measurements were obtained with stimulating electrodes of different lengths (0.3 or 0.5 mm) and different surface characteristics (smooth or porous). EEPs elicited with a fixed current under each set of electrode conditions were recorded; three measurement sessions were performed for each rabbit. The resistance at each electrode–tissue interface was measured.

Results

The latencies and amplitudes of the EEPs did not differ significantly with changes in the height and surface characteristics of the stimulating electrodes, but the resistances at the electrode–tissue interface differed significantly (P = 0.001; the resistance values for the 0.3-mm-long electrode with a porous surface was 5.24 ± 0.67 kΩ and with the 0.3- and 0.5-mm-long electrodes with smooth surfaces were 7.63 ± 0.12 kΩ and 6.77 ± 0.20 kΩ).

Conclusion

Being shorter did not affect the EEPs of the stimulating electrodes with a porous surface while decreasing the resistance at the electrode–tissue interface.

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Data availability

All data generated or analysed during this study are included in this article. Further enquiries can be directed to the corresponding author.

References

  1. World Health Organization. Blindness and vision impairment. 2021. https://www.who.int/news-room/fact-sheets/detail/blindness-and-visual-impairment. Accessed 3 Jan 2022.

  2. Morizane Y, Morimoto N, Fujiwara A, Kawasaki R, Yamashita H, Ogura Y, et al. Incidence and causes of visual impairment in Japan: the first nation-wide complete enumeration survey of newly certified visually impaired individuals. Jpn J Ophthalmol. 2019;63:26–33.

    Article  PubMed  Google Scholar 

  3. Russell S, Bennett J, Wellman JA, Chung DC, Yu ZF, Tillman A, et al. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Lancet. 2017;390:849–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sahel JA, Boulanger-Scemama E, Pagot C, Arleo A, Galluppi F, Martel JN, et al. Partial recovery of visual function in a blind patient after optogenetic therapy. Nat Med. 2021;27:1223–9.

    Article  CAS  PubMed  Google Scholar 

  5. Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, et al. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proc Natl Acad Sci USA. 2016;113:E81–90.

    Article  CAS  PubMed  Google Scholar 

  6. da Cruz L, Dorn JD, Humayun MS, Dagnelie G, Handa J, Barale PO, et al. Five-year safety and performance results from the Argus II retinal prosthesis system clinical trial. Ophthalmology. 2016;123:2248–54.

    Article  PubMed  Google Scholar 

  7. Chen J, Poulaki V, Kim SJ, Eldred WD, Kane S, Gingerich M, et al. Implantation and extraction of penetrating electrode arrays in minipig retinas. Transl Vis Sci Technol. 2020;9:19.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Edwards TL, Cottriall CL, Xue K, Simunovic MP, Ramsden JD, Zrenner E, et al. Assessment of the electronic retinal implant alpha AMS in restoring vision to blind patients with end-stage retinitis pigmentosa. Ophthalmology. 2018;125:432–43.

    Article  PubMed  Google Scholar 

  9. Sinclair NC, Shivdasani MN, Perera T, Gillespie LN, McDermott HJ, Ayton LN, et al. The appearance of phosphenes elicited using a suprachoroidal retinal prosthesis. Invest Ophthalmol Vis Sci. 2016;57:4948–61.

    Article  PubMed  Google Scholar 

  10. Sakaguchi H, Fujikado T, Fang X, Kanda H, Osanai M, Nakauchi K, et al. Transretinal electrical stimulation with a suprachoroidal multichannel electrode in rabbit eyes. Jpn J Ophthalmol. 2004;48:256–61.

    Article  PubMed  Google Scholar 

  11. Nishida K, Kamei M, Kondo M, Sakaguchi H, Suzuki M, Fujikado T, et al. Efficacy of suprachoroidal-transretinal stimulation in a rabbit model of retinal degeneration. Invest Ophthalmol Vis Sci. 2010;51:2263–8.

    Article  PubMed  Google Scholar 

  12. Fujikado T, Kamei M, Sakaguchi H, Kanda H, Endo T, Hirota M, et al. One-year outcome of 49-channel suprachoroidal-transretinal stimulation prosthesis in patients with advanced retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2016;57:6147–57.

    Article  CAS  PubMed  Google Scholar 

  13. Morimoto T, Fujikado T, Kanda H, Miyoshi T, Endo T, Nishida K, et al. Testing of newly developed wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in dogs. Transl Vis Sci Technol. 2021;10:13.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Santos A, Humayun MS, de Juan E Jr, Greenburg RJ, Marsh MJ, Klock IB, et al. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch Ophthalmol. 1997;115:511–5.

    Article  CAS  PubMed  Google Scholar 

  15. Sakaguchi H, Fujikado T, Kanda H, Osanai M, Fang X, Nakauchi K, et al. Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes. Jpn J Ophthalmol. 2004;48:552–7.

    Article  PubMed  Google Scholar 

  16. Fang X, Sakaguchi H, Fujikado T, Osanai M, Ikuno Y, Kamei M, et al. Electrophysiological and histological studies of chronically implanted intrapapillary microelectrodes in rabbit eyes. Graefes Arch Clin Exp Ophthalmol. 2006;244:364–75.

    Article  PubMed  Google Scholar 

  17. Sakaguchi H, Kamei M, Fujikado T, Yonezawa E, Ozawa M, Cecilia-Gonzalez C, et al. Artificial vision by direct optic nerve electrode (AV-DONE) implantation in a blind patient with retinitis pigmentosa. J Artif Organs. 2009;12:206–9.

    Article  PubMed  Google Scholar 

  18. Nishida K, Sakaguchi H, Kamei M, Cecilia-Gonzalez C, Terasawa Y, Velez-Montoya R, et al. Visual sensation by electrical stimulation using a new direct optic nerve electrode device. Brain Stimul. 2015;8:678–81.

    Article  PubMed  Google Scholar 

  19. Nishida K, Sakaguchi H, Kamei M, Saito T, Fujikado T, Nishida K. Electrophysiological evaluation of a chronically implanted electrode for suprachoroidal transretinal stimulation in rabbit eyes. J Artif Organs. 2019;22:237–45.

    Article  PubMed  Google Scholar 

  20. Terasawa Y, Tashiro H, Nakano Y, Ohta J. Safety and efficacy of semichronic suprachoroidal transretinal stimulation with femtosecond laser-induced porosity and smooth-surface electrodes. Sens Mater. 2018;30(2):235–49.

    CAS  Google Scholar 

  21. Hagihira S. Changes in the electroencephalogram during anaesthesia and their physiological basis. Br J Anaesth. 2015;115(Suppl 1):i27–31.

    Article  PubMed  Google Scholar 

  22. Shin HW, Kim HJ, Jang YK, You HS, Huh H, Choi YJ, et al. Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia. BMC Anesthesiol. 2020;20:49.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

This work was supported by JSPS KAKENHI Grant Number 21K12809 and JRPS Grant 2020. Special thanks to Prof. Ryo Kawasaki for advice for statistical analysis. Medical writing and editing support were provided by Editage.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, #E7, Suita, 565-0871, Japan

    Kentaro Nishida, Takeshi Morimoto, Hirokazu Sakaguchi, Takashi Fujikado & Kohji Nishida

  2. R&D Division, Artificial Vision Institute, NIDEK Co., Ltd., Gamagori, Japan

    Yasuo Terasawa

  3. Department of Ophthalmology, Gifu University Graduate School of Medicine, Yanagido, Gifu, Japan

    Hirokazu Sakaguchi

  4. Department of Ophthalmology, Aichi Medical University, Nagakute, Japan

    Motohiro Kamei

  5. Department of Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan

    Tomomitsu Miyoshi

  6. Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan

    Kohji Nishida

Authors
  1. Kentaro Nishida
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  2. Takeshi Morimoto
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  3. Yasuo Terasawa
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  4. Hirokazu Sakaguchi
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  5. Motohiro Kamei
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  6. Tomomitsu Miyoshi
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  7. Takashi Fujikado
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  8. Kohji Nishida
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Corresponding author

Correspondence to Kentaro Nishida.

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Conflicts of interst

Kentaro Nishida, None; T. Morimoto, None; Y. Terasawa, Employee (NIDEK), NIDEK and the author own the patent for Stimulus electrode for biological tissue and method of producing the stimulus electrode; H. Sakaguchi, None; M. Kamei, None; T. Miyoshi, None; T. Fujikado, None; Kohji Nishida, None.

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Corresponding Author: Kentaro Nishida

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Nishida, K., Morimoto, T., Terasawa, Y. et al. The influence of stimulating electrode conditions on electrically evoked potentials and resistance in suprachoroidal transretinal stimulation. Jpn J Ophthalmol 67, 182–188 (2023). https://doi.org/10.1007/s10384-022-00972-7

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  • DOI: https://doi.org/10.1007/s10384-022-00972-7

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