Abstract
Purpose
To determine the capabilities of “EyeGround” software in measuring the choroidal cross sectional areas in optical coherence tomographic (OCT) images.
Study design
Cross sectional, prospective study.
Methods
The cross-sectional area of the subfoveal choroid within a 1500 µm diameter circle centered on the fovea was measured both with and without using the EyeGround software in the OCT images. The differences between the evaluation times and the results of the measurements were compared. The inter-rater, intra-rater, inter-method agreements were determined.
Results
Fifty-one eyes of 51 healthy subjects were studied: 24 men and 27 women with an average age of 35.0 ± 8.8 years. The time for analyzing a single image was significantly shorter with the software at 3.2±1.1 min than without the software at 12.1±5.1 min (P <0.001). The inter-method correlation efficient for the measurements of the whole choroid was high [0.989, 95% CI (0.981-0.994)]. With the software, the inter-rater correlation efficient was significantly high [0.997, 95% CI (0.995-0.999)], and the intra-rater correlation efficient was also significantly high [0.999, 95% CI (0.999-1.0)].
Conclusion
The EyeGround software can measure the choroidal area in the OCT cross sectional images with good reproducibility and in a significantly shorter times. It can be a valuable tool for analyzing the choroid.
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Acknowledgements
The authors thank Professor Emeritus Duco Hamasaki of the Bascom Palmer Eye Institute of the University of Miami for providing critical discussions and suggestions to our study and revision of the final manuscript. This study was done by a grant from the Research Committee on Chorioretinal Degeneration and Optic Atrophy, Ministry of Health, Labor, and Welfare, Tokyo, Japan; and by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of the Japanese Government, Tokyo, Japan.
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S. Sonoda, None; T. Sakamoto, None; N. Kakiuchi, None; H. Shiihara, None; T. Sakoguchi, None; M. Tomita, None; T. Yamashita, None; E. Uchino, None.
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10384_2017_558_MOESM1_ESM.tif
Supplementary Fig. S1 Representative images of the protocol of EyeGround software. Detailed protocol is as described in Methods. (a). Screen image of step 4. (b) Screen image of step 6-1. (c) Screen image of step 6-2. (d) Screen image of step 6-3. (e) Screen image of step 7. (f) Screen image of step 8. (g) Screen image of step 9.OCT Images with EyeGround software screen. (TIFF 675 kb)
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Sonoda, S., Sakamoto, T., Kakiuchi, N. et al. Semi-automated software to measure luminal and stromal areas of choroid in optical coherence tomographic images. Jpn J Ophthalmol 62, 179–185 (2018). https://doi.org/10.1007/s10384-017-0558-1
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DOI: https://doi.org/10.1007/s10384-017-0558-1