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Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings.

Case

An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well.

Conclusion

IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium.

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Acknowledgments

The authors thank Prof. Tomosada Sugimoto (Department of Oral Function and Anatomy), Prof. Aiji Ohtsuka (Department of Human Morphology), Prof. Takehito Taguchi (Faculty of Health Science, Department of Human Morphology), and Prof. Emeritus Junzo Sasaki (Department of Cytology and Histology) (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) for their detailed descriptions of the anatomy of the infraorbital nerve and for providing permission to prepare normal infraorbital nerve specimens.

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Authors and Affiliations

  1. Department of Ophthalmology, Mitoyo General Hospital, 708 Himehama, Toyohama-cho, Kanonji, Kagawa, 769-1695, Japan

    Yuka Sogabe

  2. Department of Pathology, Mitoyo General Hospital, Kanonji, Japan

    Katsuya Miyatani

  3. Department of Otolaryngology-Head and Neck Surgery, Mitoyo General Hospital, Kanonji, Japan

    Rieko Goto & Gengo Ishii

  4. Section of Ophthalmology, National Hospital Organization Okayama Medical Center, Okayama, Japan

    Koh-ichi Ohshima

  5. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Yasuharu Sato

Authors
  1. Yuka Sogabe
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  2. Katsuya Miyatani
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  3. Rieko Goto
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  4. Gengo Ishii
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  5. Koh-ichi Ohshima
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  6. Yasuharu Sato
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Corresponding author

Correspondence to Yuka Sogabe.

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Sogabe, Y., Miyatani, K., Goto, R. et al. Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease. Jpn J Ophthalmol 56, 511–514 (2012). https://doi.org/10.1007/s10384-012-0170-3

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  • DOI: https://doi.org/10.1007/s10384-012-0170-3

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