Skip to main content

Advertisement

Log in

Intravitreal bevacizumab for iatrogenic choroidal neovascularization due to laser photocoagulation in central serous chorioretinopathy

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Background

Choroidal neovascularization (CNV) is well recognized as a complication of laser photocoagulation for central serous chorioretinopathy (CSC). However, little is known about its management.

Patients

Two patients who developed iatrogenic CNV after laser photocoagulation for CSC.

Observations

A single intravitreal bevacizumab (IVB) injection was given in both cases. The best-corrected visual acuity (BCVA) of 1 of the patients improved from 0.3 to 0.5 on the following day and to 1.2 three months after the IVB, and the BCVA of the other patient improved from 0.5 to 1.0 two weeks after the IVB. In both cases, the CNV became inactive 1 month after IVB on fluorescein angiography and remained stable for over 1 year.

Conclusion

IVB was beneficial for iatrogenic CNV that developed after laser photocoagulation for CSC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Gemenetzi M, De Salvo G, Lotery AJ. Central serous chorioretinopathy: an update on pathogenesis and treatment. Eye (Lond). 2010;24:1743–56.

    Article  CAS  Google Scholar 

  2. Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N. Restoration of outer segments of foveal photoreceptors after resolution of central serous chorioretinopathy. Jpn J Ophthalmol. 2010;54:55–60.

    Article  PubMed  Google Scholar 

  3. Wang M, Munch IC, Hasler PW, Prunte C, Larsen M. Central serous chorioretinopathy. Acta Ophthalmol. 2008;86:126–45.

    Article  PubMed  Google Scholar 

  4. Robertson DM, Ilstrup D. Direct, indirect, and sham laser photocoagulation in the management of central serous chorioretinopathy. Am J Ophthalmol. 1983;95:457–66.

    PubMed  CAS  Google Scholar 

  5. Ha TW, Ham DI, Kang SW. Management of choroidal neovascularization following laser photocoagulation for central serous chorioretinopathy. Korean J Ophthalmol. 2002;16:88–92.

    PubMed  Google Scholar 

  6. Cakir M, Cekic O, Yilmaz OF. Photodynamic therapy for iatrogenic CNV due to laser photocoagulation in central serous chorioretinopathy. Ophthalmic Surg Lasers Imaging. 2009;40:405–8.

    Article  PubMed  Google Scholar 

  7. Pikkel J, Rumelt S. Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy. Eur J Ophthalmol. 2011. doi:10.5301/ejo.5000036.

    Google Scholar 

  8. Gass JD. Photocoagulation treatment of idiopathic central serous choroidopathy. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1977;83:456–67.

    PubMed  CAS  Google Scholar 

  9. Matsunaga H, Nangoh K, Uyama M, Nanbu H, Fujiseki Y, Takahashi K. Occurrence of choroidal neovascularization following photocoagulation treatment for central serous retinopathy. Nihon Ganka Gakkai Zasshi. 1995;99:460–8 (in Japanese).

    Google Scholar 

  10. Yoshioka H, Katsume Y. Experimental central serous chorioretinopathy. III: ultrastructural findings. Jpn J Ophthalmol. 1982;26:397–409.

    PubMed  CAS  Google Scholar 

  11. Kanyange ML, De Laey JJ. Long-term follow-up of central serous chorioretinopathy (CSCR). Bull Soc Belge Ophtalmol. 2002;284:39–44.

    PubMed  Google Scholar 

  12. Chan WM, Lam DS, Lai TY, Yuen KS, Liu DT, Chan CK, et al. Treatment of choroidal neovascularization in central serous chorioretinopathy by photodynamic therapy with verteporfin. Am J Ophthalmol. 2003;136:836–45.

    Article  PubMed  CAS  Google Scholar 

  13. Nishiyama Y, Mori K, Murayama K, Yoneya S. Quantitative analysis of indocyanine green angiographic image in central serous chorioretinopathy. Jpn J Ophthalmol. 2001;45:116.

    Article  PubMed  Google Scholar 

  14. Yannuzzi LA, Freund KB, Goldbaum M, Scassellati-Sforzolini B, Guyer DR, Spaide RF, et al. Polypoidal choroidal vasculopathy masquerading as central serous chorioretinopathy. Ophthalmology. 2000;107:767–77.

    Article  PubMed  CAS  Google Scholar 

  15. Schatz H, Yannuzzi LA, Gitter KA. Subretinal neovascularization following argon laser photocoagulation treatment for central serous chorioretinopathy: complication or misdiagnosis? Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1977;83:893–906.

    PubMed  CAS  Google Scholar 

  16. Robertson DM. Argon laser photocoagulation treatment in central serous chorioretinopathy. Ophthalmology. 1986;93:972–4.

    PubMed  CAS  Google Scholar 

  17. Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 2003;349:427–34.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yoko Nomura.

About this article

Cite this article

Nomura, Y., Obata, R. & Yanagi, Y. Intravitreal bevacizumab for iatrogenic choroidal neovascularization due to laser photocoagulation in central serous chorioretinopathy. Jpn J Ophthalmol 56, 245–249 (2012). https://doi.org/10.1007/s10384-012-0138-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-012-0138-3

Keywords

Navigation