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Difference in redox status of serum and aqueous humor in senile cataract patients as monitored via the albumin thiol-redox state

  • Clinical Investigation
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Abstract

Purpose

To clarify the redox states of the aqueous humor and serum in senile cataract patients.

Methods

We analyzed the reduced and oxidized albumin fractions in 58 patients. The patients had no detectable evidence of other eye or systemic diseases and were divided into two age groups (53–75 and 76-96 years). Analysis was performed with a high-performance liquid chromatographic system with a fluorescence detector.

Results

Extremely small amounts of reduced albumin (3.8% and 3.6% in the younger and older groups, respectively) and markedly large amounts of oxidized albumin (96.2% and 96.4%, respectively) were found in the aqueous humor. Moreover, a higher percentage of oxidized albumin, particularly a highly oxidized irreversible form of albumin, was found in the aqueous humor (12.3% and 12.0%) than in the serum (2.4% and 3.0%).

Conclusions

In senile cataract patients with no complications, the redox state of albumin in the aqueous humor differs considerably, both quantitatively and qualitatively, from that in the serum.

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Authors and Affiliations

  1. Department of Ophthalmology, Tokai University School of Medicine, Kanagawa, Japan

    Kenji Kawai

  2. Department of Physiology, Meiji University of Oriental Medicine, Kyoto, Japan

    Tomoya Hayashi

  3. Department of Physiology and Biophysics, Gifu University Graduate School of Medicine, Gifu, Japan

    Yukie Matsuyama, Takeshi Minami & Seiichi Era

  4. Department of Ophthalmology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259-1193, Japan

    Kenji Kawai

Authors
  1. Kenji Kawai
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  2. Tomoya Hayashi
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  3. Yukie Matsuyama
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  4. Takeshi Minami
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  5. Seiichi Era
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Corresponding author

Correspondence to Kenji Kawai.

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Kawai, K., Hayashi, T., Matsuyama, Y. et al. Difference in redox status of serum and aqueous humor in senile cataract patients as monitored via the albumin thiol-redox state. Jpn J Ophthalmol 54, 584–588 (2010). https://doi.org/10.1007/s10384-010-0877-y

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  • DOI: https://doi.org/10.1007/s10384-010-0877-y

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