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Giant pedunculated liposarcoma of the esophagus

  • case report
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Summary

Background

Liposarcoma is a common soft tissue neoplasm but its presence within the gastrointestinal system, especially the esophagus, is quite rare. It usually presents as an intraluminal or an intramural mass, with symptoms such as dysphagia and throat discomfort. Liposarcoma must be differentiated from benign tumors of the esophagus and managed appropriately.

Case presentation

In this report, we present the case of a 26-year-old woman who complained of dysphagia to liquids and solids and vague abdominal discomfort. The radiological modalities and endoscopic examination revealed a near-obstructing esophageal polypoid mass of 15 × 7.5 cm in size in the thoracal esophagus. A diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma was made with morphological and immunohistochemical findings.

Discussion

Esophageal liposarcomas originate from primitive mesenchymal cells and are divided into several subtypes, with well-differentiated liposarcoma being the most common subtype. Various diagnostic tests are available, such as barium swallow, computerized tomography, magnetic resonance imaging, and esophagogastroduodenoscopy. Depending on the size and location of the tumor, minimally invasive endoscopic resection or more radical surgery such as esophagectomy can be performed.

Conclusion

Modern radiological imaging modalities have allowed better understanding and early diagnosis of lipomatous tumors of the esophagus. Optimal management varies, but minimally invasive techniques allow easy removal of the tumor stalk. However, more radical surgery such as esophagectomy is still performed. Due to its rarity, little is known about the prognosis of esophageal liposarcoma. Patients should be followed-up closely in the long term regarding recurrence.

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References

  1. Smith MA, Kluck E, Jagannath S, et al. Giant multi-polypoid liposarcoma of the esophagus: an atypical presentation. Ann Thorac Surg. 2010;89(2):610–2.

    Article  Google Scholar 

  2. Takiguchi G, Nakamura T, Otowa Y, et al. Successful resection of giant esophageal liposarcoma by endoscopic submucosal dissection combined with surgical retrieval: a case report and literature review. surg case rep. 2016;2(1):90.

    Article  Google Scholar 

  3. Ye YW, Liao MY, Mou ZM, et al. Thoracoscopic resection of a huge esophageal dedifferentiated liposarcoma: a case report. World J Clin Cases. 2020;8(9):1698–704.

    Article  Google Scholar 

  4. Valiuddin HM, Barbetta A, Mungo B, et al. Esophageal liposarcoma: well-differentiated rhabdomyomatous type. World J Gastrointest Oncol. 2016;8(12):835–9.

    Article  Google Scholar 

  5. Yang J, Ren Z, Du X, et al. The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute. Stem Cell Investig. 2014;1:18.

    PubMed  PubMed Central  Google Scholar 

  6. Lin ZC, Chang XZ, Huang XF, et al. Giant liposarcoma of the esophagus: a case report. World J Gastroenterol. 2015;21(33):9827–32.

    Article  Google Scholar 

  7. Ortega P, Suster D, Falconieri G, Zambrano E, Moran CA, Morrison C, Suster S. Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases. Mod Pathol. 2015;28(5):721–31.

    Article  CAS  Google Scholar 

  8. Beaudoin A, Journet C, Watier A, et al. Giant liposarcoma of the esophagus. Can J Gastroenterol. 2002;16(6):377–9.

    Article  Google Scholar 

  9. Jakowski JD, Wakely PE Jr.. Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus. Ann Diagn Pathol. 2009;13(4):263–8.

    Article  Google Scholar 

  10. Parikh MP, Chandran A, Satiya J, et al. Dedifferentiated liposarcoma in a giant esophageal polyp: a case report and review of the literature. Cureus. 2019;11(4):e4480.

    PubMed  PubMed Central  Google Scholar 

  11. Graham RP, Yasir S, Fritchie KJ, et al. Polypoid fibro adipose tumors of the esophagus: ‘giant fibrovascular polyp’ or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases. Mod Pathol. 2018;31(2):337–42.

    Article  Google Scholar 

  12. Sirvent N, Coindre JM, Maire G, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89.

    Article  Google Scholar 

  13. Myung JK, Jeong JB, Han D, et al. Well-differentiated liposarcoma of the oesophagus: clinicopathological, immunohistochemical and array CGH analysis. Pathol Oncol Res. 2011;17(2):415–20.

    Article  Google Scholar 

  14. Yang B, Shi PZ, Li X, et al. Well-differentiated liposarcoma of esophagus. Chin Med J. 2006;119(5):438–40.

    Article  Google Scholar 

  15. Liakakos TD, Troupis TG, Tzathas C, et al. Primary liposarcoma of esophagus: a case report. World J Gastroenterol. 2006;12:114952.

    Article  Google Scholar 

  16. Ferrari D, Bernardi D, Siboni S, et al. Esophageal lipoma and liposarcoma: a systematic review. World J Surg. 2021;45(1):225–34.

    Article  Google Scholar 

  17. Baldaque-Silva F, Marques M, Sanchez-Hernandez E, et al. Endoscopic submucosal dissection of a giant esophageal lipoma. Am J Gastroenterol. 2016;111:1680.

    Article  Google Scholar 

  18. Ferro RM, Pinilla Morales R. Advanced endoscopic resection using endoscopic submucosal dissection technique to resect a giant, lumen-occluding esophageal polyp. Endoscopy. 2019;51(6):E151–E2.

    Article  Google Scholar 

  19. Enzinger FM, Winslow DJ. Liposarcoma. Virchows Arch A Pathol Anat. 1962;335:367–88.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of General Surgery, Istanbul University Cerrahpasa—Cerrahpasa School of Medicine, Istanbul, Turkey

    Mehmet Faik Ozcelik MD, Sinan Carkman MD, Ergin Erginoz MD, BS, MSc, PhD & Haktan Ovul Bozkir MD

  2. Department of Pathology, Istanbul University Cerrahpasa—Cerrahpasa School of Medicine, Istanbul, Turkey

    Gokce Hande Cavus MD

Authors
  1. Mehmet Faik Ozcelik MD
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  2. Sinan Carkman MD
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  3. Ergin Erginoz MD, BS, MSc, PhD
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  4. Gokce Hande Cavus MD
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  5. Haktan Ovul Bozkir MD
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Corresponding author

Correspondence to Ergin Erginoz MD, BS, MSc, PhD.

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Conflict of interest

M.F. Ozcelik, S. Carkman, E. Erginoz, G.H. Cavus, and H.O. Bozkir declare that they have no competing interests.

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Ozcelik, M.F., Carkman, S., Erginoz, E. et al. Giant pedunculated liposarcoma of the esophagus. Eur Surg 54, 217–220 (2022). https://doi.org/10.1007/s10353-022-00764-w

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  • DOI: https://doi.org/10.1007/s10353-022-00764-w

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