Abstract
The laboratory of functional neuroelectrical imaging and brain–computer interfacing at Fondazione Santa Lucia is based on the joint work of researchers with a bioengineering and clinical neurophysiology background. The activity is mainly devoted to two aims: the non-invasive investigation of the motor cortical function under physiological and pathological conditions, through the development of advanced processing methods of the electroencephalographic signals; the development of a real-time EEG-based brain–computer interface (BCI) and the study of its use as an aid to enhance (or even to allow) the functional independence of persons with different degrees of motor disability.
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Astolfi L, Cincotti F, Babiloni C, Basilisco A, Rossini PM, Marciani MG, Mattia D, Salinari S, Ben Dayan D, Ding L, Ni Y, He B, Babiloni F (2005a) Assessing cortical functional connectivity by linear inverse estimation and directed transfer function: simulations and application to real data. Clin Neurophysiol (in press)
Astolfi L, Cincotti F, Babiloni C, Carducci F, Basilisco A, Rossini PM, Salinari S, Mattia D, Cerutti S, Ben Dayan D, Ni Y, He B, Babiloni F (2005b) Estimation of the cortical connectivity by high resolution EEG and structural equation modeling: simulations and application to finger tapping data. IEEE Trans Biomed Eng (in press)
Astolfi L, Cincotti F, Mattia D, Salinari S, Babiloni C, Basilisco A, Rossini PM, Marciani MG, Babiloni F (2005c) Estimation of the effective and functional human cortical connectivity with structural equation modeling and directed transfer function applied on high resolution EEG. Magn Res Imag (in press)
Babiloni F, Cincotti F (2004) Multimodal imaging from neuroelectromagnetic and functional magnetic resonance recordings. In: He B (ed) Modeling and imaging of bioelectrical activity: principles and applications. Kluwer, Plenum, New York
Babiloni F, Babiloni C, Carducci F, Fattorini L, Onorati P, Urbano A (1996) Spline Laplacian estimate of EEG potentials over a realistic magnetic resonance-constructed scalp surface model. Electroencephalogr Clin Neurophysiol 98(4):363—373
Babiloni F, Babiloni C, Locche L, Cincotti F, Rossini PM, Carducci F (2000a) High-resolution electro-encephalogram: source estimates of Laplacian-transformed somatosensory-evoked potentials using a realistic subject head model constructed from magnetic resonance images. Med Biol Eng Comput 38(5):512—519
Babiloni F, Cincotti F, Lazzarini L, Millan J, Mourino J, Varsta M, Heikkonen J, Bianchi L, Marciani MG (2000b) Linear classification of low-resolution EEG patterns produced by imagined hand movements. IEEE Trans Rehabil Eng 8(2):186–188
Babiloni F, Cincotti F, Bianchi L, Pirri G, del RM, Mourino J, Salinari S, Marciani MG (2001) Recognition of imagined hand movements with low resolution surface Laplacian and linear classifiers. Med Eng Phys 23(5):323–328
Babiloni F, Babiloni C, Carducci F, Cincotti F, Rossini PM (2003a) ‘The stone of madness’ and the search for the cortical sources of brain diseases with non-invasive EEG techniques. Clin Neurophysiol 114(10):1775–1780
Babiloni F, Babiloni C, Carducci F, Romani GL, Rossini PM, Angelone LM, Cincotti F (2003b) Multimodal integration of high-resolution EEG and functional magnetic resonance imaging data: a simulation study. Neuroimage 19(1):1–15
Babiloni F, Cincotti F, Babiloni C, Carducci F, Basilisco A, Rossini PM, Mattia D, Astolfi L, Ding L, Ni Y, Cheng K, Christine K, Sweeney J, He B (2005a) Estimation of the cortical functional connectivity with the multimodal integration of high resolution EEG and fMRI data by Directed Transfer Function. Neuroimage 24(1):118–131
Babiloni F, Mattia D, Babiloni C, Astolfi L, Salinari S, Basilisco A, Rossini PM, Marciani MG, Cincotti F (2005b) Multimodal integration of EEG, MEG and fMRI data for the solution of the neuroimage puzzle. Magn Res Imag (in press)
Bianchi L, Babiloni F, Cincotti F, Arrivas M, Bollero P, Marciani MG (2003a) Developing wearable bio-feedback systems: a general-purpose platform. IEEE Trans Neural Syst Rehabil Eng 11(2):117–119
Bianchi L, Babiloni F, Cincotti F, Salinari S, Marciani MG (2003b) Introducing BF++: AC++ framework for cognitive bio-feedback systems design. Methods Inf Med 42(1):104–110
Bollen KA (1989) Structural equations with latent variables. Wiley, New York
Cincotti F, Mattia D, Babiloni C, Carducci F, Bianchi L, del RM, Mourino J, Salinari S, Marciani MG, Babiloni F (2002) Classification of EEG mental patterns by using two scalp electrodes and Mahalanobis distance-based classifiers. Methods Inf Med 41(4):337–341
Cincotti F, Mattia D, Babiloni C, Carducci F, Salinari S, Bianchi L, Marciani MG, Babiloni F (2003) The use of EEG modifications due to motor imagery for brain–computer interfaces. IEEE Trans Neural Syst Rehabil Eng 11(2):131–133
Cincotti F, Babiloni C, Miniussi C, Carducci F, Moretti D, Salinari S, Pascual-Marqui R, Rossini PM, Babiloni F (2004a) EEG deblurring techniques in a clinical context. Methods Inf Med 43(1):114–117
Cincotti F, Mattia D, Mattiocco M, Timperi A, Campani G, Salinari S, Marciani MG, Babiloni F (2004b) Detection of cortical activity asymmetries from non invasive EEG recordings for brain computer interface applications. In: The 10th annual meeting of the organization for human brain mapping
Curt A, Alkadhi H, Crelier GR, Boendermaker SH, Hepp-Reymond MC, Kollias SS (2002) Changes of non-affected upper limb cortical representation in paraplegic patients as assessed by fMRI. Brain 125(11):2567–2578
Dale AM, Sereno M (1993) Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface recostruction: a linear approach. J Cogn Neurosci 5:162–176
Dale AM, Liu AK, Fischl BR, Buckner RL, Belliveau JW, Lewine JD, Halgren E (2000) Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity. Neuron 26(1):55–67
Hämäläinen M, Ilmoniemi R (1984) Measured magnetic field of the brain: estimates of the current distributions. Technical report TKK-F-A559, Helsinki University of Technology, Helsinki
Hjorth B (1975) An on-line transformation of EEG scalp potentials into orthogonal source derivations. Electroencephalogr Clin Neurophysiol 39(5):526–530
Jancke L, Loose R, Lutz K, Specht K, Shah NJ (2000) Cortical activations during paced finger-tapping applying visual and auditory pacing stimuli. Brain Res Cogn Brain Res 10(1–2):51–66
Kaminski M, Ding M, Truccolo WA, Bressler SL (2001) Evaluating causal relations in neural systems: granger causality, directed transfer function and statistical assessment of significance. Biol Cybern 85(2):145–157
Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412(6843):150–157
Magistretti PJ, Pellerin L, Rothman DL, Shulman RG (1999) Energy on demand. Science 283(5401):496–497
Mattia D, Cincotti F, Zomparelli B, Mattiocco M, Marciani MG, Babiloni F (2004) Motor-cortical activity in spinal cord injury: pattern of EEG reactivity during no overt movement. In: The 10th annual meeting of the organization for human brain mapping
McFarland DJ, McCane LM, David SV, Wolpaw JR (1997) Spatial filter selection for EEG-based communication. Electroencephalogr Clin Neurophysiol 103(3):386–394
McIntosh AR, Gonzalez-Lima F (1994) Structural equation modelling and its application to network analysis in functional brain imaging. Hum Brain Mapp 2(1–2):2–22
Michel CM, Murray MM, Lantz G, Gonzalez S, Spinelli L, Grave dP (2004) EEG source imaging. Clin Neurophysiol 115(10):2195–2222
Millan J, Franze M, Mourino J, Cincotti F, Babiloni F (2002) Relevant EEG features for the classification of spontaneous motor-related tasks. Biol Cybern 86(2):89–95
Millàn J, Mourino J, Franzé M, Cincotti F, Varsta M, Heikkonen J, Babiloni F (2002) A local neural classifier for the recognition of EEG patterns associated to mental tasks. IEEE Trans Neural Netw 13(3):678–686
Salmelin R, Hamalainen M, Kajola M, Hari R (1995) Functional segregation of movement-related rhythmic activity in the human brain. Neuroimage 2(4):237–243
Schalk G, McFarland DJ, Hinterberger T, Birbaumer N, Wolpaw JR (2004) BCI2000: a general-purpose brain–computer interface (BCI) system. IEEE Trans Biomed Eng 51(6):1034–1043
Shoham S, Halgren E, Maynard EM, Normann RA (2001) Motor-cortical activity in tetraplegics. Nature 413(6858):793
Volkmann J, Joliot M, Mogilner A, Ioannides AA, Lado F, Fazzini E, Ribary U, Llinas R (1996) Central motor loop oscillations in parkinsonian resting tremor revealed by magnetoencephalography. Neurology 46(5):1359–1370
Acknowledgements
The activity of the laboratory is funded in part by the Fondazione Telethon onlus, grant GUP03562; we would like to acknowledge Dr. Gianni Nicolai and Mr. Danilo Mattia for their technical contribution.
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Communicated by Irene Ruspantini and Niels Birbaumer
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Cincotti, F., Babiloni, F., Mattiocco, M. et al. Laboratory of functional neuroelectrical imaging and brain–computer interfacing at Fondazione Santa Lucia. Cogn Process 6, 75–83 (2005). https://doi.org/10.1007/s10339-004-0044-9
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DOI: https://doi.org/10.1007/s10339-004-0044-9