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Les lignanes phytoestrogènes du lin sont-ils des bienfaiteurs méconnus?

Do flax lignans have misknown benefits?

  • Article original
  • Pharmacognosie
  • Published:
Phytothérapie

Résumé

Les graines du lin contiennent des teneurs très élevées en composés phénoliques, les lignanes, en particulier en sécoisolaricirésinol diglucoside (SDG). Ses propriétés antioxydantes et de liaison aux récepteurs oestrogéniques pourraient expliquer ses activités biologiques en rapport avec la prévention de certains cancers et des maladies cardiovasculaires. On observe cependant des résultats contradictoires parmi les études épidémiologiques publiées à ce jour. Toutefois, malgré la qualification de phytoestrogène du SDG, il n’a jamais été observé de stimulation de croissance de cellules cancéreuses. La connaissance du devenir des lignanes ingérés et de leurs interactions possibles avec notre métabolisme, en particulier hormonal, progresse. La récente disponibilité de produit purifié permet maintenant d’en étudier les effets in vitro.

Abstract

Linseed contains an high lignan content, peculiarly secoisolariciresinol diglucoside (SDG). Antioxydant properties as well as it’s ability to bind estrogen receptors could explain its biological activities and preventive action against cancers and cardiovascular disease. Epidemiological studies have yielded contradictory results on the benefits of SDG. Nevertheless it is worth to note that, although classified as phyoestrogen, no detrimental effect of SDG (such as tumorous cell growth stimulation) has been observed. Our knowledge is increasing in the field of lignan intake and metabolism and further interaction with our metabolism, particularly the sexual hormones one. The recent availability of purified products now allows in vitro studies to better understand the biological activities of lignans.

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Authors and Affiliations

  1. Enseignants chercheurs de l’université d’Orléans. Unité EA 1207 Biologie des ligneux et grandes cultures, Antenne scientifique universitaire de Chartres, 21, rue de Loigny-la-Bataille, 28000, Chartres, France

    E. Lainé, C. Hano & F. Lamblin

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  1. E. Lainé
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  2. C. Hano
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  3. F. Lamblin
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Correspondence to E. Lainé.

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Lainé, E., Hano, C. & Lamblin, F. Les lignanes phytoestrogènes du lin sont-ils des bienfaiteurs méconnus?. Phytothérapie 5, 121–128 (2007). https://doi.org/10.1007/s10298-007-0237-3

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  • DOI: https://doi.org/10.1007/s10298-007-0237-3

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