Skip to main content
SpringerLink
Log in

Asymptomatic orthostatic hypotension in synucleinopathies: to treat or not to treat?

  • View point
  • Published:
Clinical Autonomic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data availability

Not applicable.

References

  1. Wieling W, Kaufmann H, Claydon VE, van Wijnen VK, Harms MPM, Juraschek SP et al (2022) Diagnosis and treatment of orthostatic hypotension. Lancet Neurol 21(8):735–746. https://doi.org/10.1016/s1474-4422(22)00169-7

    Article  PubMed  PubMed Central  Google Scholar 

  2. Palma JA, Kaufmann H (2017) Epidemiology, diagnosis, and management of neurogenic orthostatic hypotension. Mov Disord Clin Pract 4(3):298–308. https://doi.org/10.1002/mdc3.12478

    Article  PubMed  PubMed Central  Google Scholar 

  3. De Pablo-Fernandez E, Tur C, Revesz T, Lees AJ, Holton JL, Warner TT (2017) Association of autonomic dysfunction with disease progression and survival in parkinson disease. JAMA Neurol 74(8):970–976. https://doi.org/10.1001/jamaneurol.2017.1125

    Article  PubMed  PubMed Central  Google Scholar 

  4. Rascol O, Perez-Lloret S, Damier P, Delval A, Derkinderen P, Destée A et al (2015) Falls in ambulatory non-demented patients with Parkinson’s disease. J Neural Transm (Vienna) 122(10):1447–1455. https://doi.org/10.1007/s00702-015-1396-2

    Article  PubMed  Google Scholar 

  5. Palma JA, Gomez-Esteban JC, Norcliffe-Kaufmann L, Martinez J, Tijero B, Berganzo K et al (2015) Orthostatic hypotension in Parkinson disease: how much you fall or how low you go? Mov Disord 30(5):639–645. https://doi.org/10.1002/mds.26079

    Article  PubMed  PubMed Central  Google Scholar 

  6. Arbogast SD, Alshekhlee A, Hussain Z, McNeeley K, Chelimsky TC (2009) Hypotension unawareness in profound orthostatic hypotension. Am J Med 122(6):574–580. https://doi.org/10.1016/j.amjmed.2008.10.040

    Article  PubMed  Google Scholar 

  7. Freeman R, Illigens BMW, Lapusca R, Campagnolo M, Abuzinadah AR, Bonyhay I et al (2020) Symptom recognition is impaired in patients with orthostatic hypotension. Hypertension 75(5):1325–1332. https://doi.org/10.1161/hypertensionaha.119.13619

    Article  CAS  PubMed  Google Scholar 

  8. Tipton PW, Cheshire WP (2020) Mechanisms underlying unawareness of neurogenic orthostatic hypotension. Clin Auton Res 3:279–281

    Article  Google Scholar 

  9. Gibbons CH, Schmidt P, Biaggioni I, Frazier-Mills C, Freeman R, Isaacson S et al (2017) The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol 264(8):1567–1582. https://doi.org/10.1007/s00415-016-8375-x

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ruiz Barrio I, Miki Y, Jaunmuktane ZT, Warner T, De Pablo-Fernandez E (2023) Association between orthostatic hypotension and dementia in patients with Parkinson disease and multiple system atrophy. Neurology 100(10):e998–e1008. https://doi.org/10.1212/wnl.0000000000201659

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Longardner K, Bayram E, Litvan I (2020) Orthostatic hypotension is associated with cognitive decline in Parkinson disease. Front Neurol 11:897. https://doi.org/10.3389/fneur.2020.00897

    Article  PubMed  PubMed Central  Google Scholar 

  12. Xia X, Wang R, Vetrano DL, Grande G, Laukka EJ, Ding M et al (2021) From normal cognition to cognitive impairment and dementia: impact of orthostatic hypotension. Hypertension 78(3):769–778. https://doi.org/10.1161/hypertensionaha.121.17454

    Article  CAS  PubMed  Google Scholar 

  13. McDonald C, Newton JL, Burn DJ (2016) Orthostatic hypotension and cognitive impairment in Parkinson’s disease: causation or association? Mov Disord 31(7):937–946. https://doi.org/10.1002/mds.26632

    Article  CAS  PubMed  Google Scholar 

  14. Donnell DO, Romero-Ortuno R, Kennelly SP, O’Neill D, Donoghue PO, Lavan A et al (2023) The ‘Bermuda Triangle’ of orthostatic hypotension, cognitive impairment and reduced mobility: prospective associations with falls and fractures in the Irish longitudinal study on ageing. Age Ageing 52(2):afad005. https://doi.org/10.1093/ageing/afad005

  15. Merola A, Romagnolo A, Rosso M, Suri R, Berndt Z, Maule S et al (2018) Autonomic dysfunction in Parkinson’s disease: a prospective cohort study. Mov Disord 33(3):391–397. https://doi.org/10.1002/mds.27268

    Article  PubMed  Google Scholar 

  16. Hauser RA, Heritier S, Rowse GJ, Hewitt LA, Isaacson SH (2016) Droxidopa and reduced falls in a trial of parkinson disease patients with neurogenic orthostatic hypotension. Clin Neuropharmacol 39(5):220–226. https://doi.org/10.1097/wnf.0000000000000168

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Sharabi Y, Goldstein DS (2011) Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease. J Neurol Sci 310(1–2):123–128. https://doi.org/10.1016/j.jns.2011.06.047

    Article  PubMed  PubMed Central  Google Scholar 

  18. Jordan J, Fanciulli A, Tank J, Calandra-Buonaura G, Cheshire WP, Cortelli P et al (2019) Management of supine hypertension in patients with neurogenic orthostatic hypotension: scientific statement of the American Autonomic Society, European Federation of Autonomic Societies, and the European Society of Hypertension. J Hypertens 37(8):1541–1546. https://doi.org/10.1097/hjh.0000000000002078

    Article  CAS  PubMed  Google Scholar 

  19. Fanciulli A, Göbel G, Ndayisaba JP, Granata R, Duerr S, Strano S et al (2016) Supine hypertension in Parkinson’s disease and multiple system atrophy. Clin Auton Res 26(2):97–105. https://doi.org/10.1007/s10286-015-0336-4

    Article  PubMed  Google Scholar 

  20. Palma JA, Redel-Traub G, Porciuncula A, Samaniego-Toro D, Millar Vernetti P, Lui YW et al (2020) The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension. Parkinsonism Relat Disord 75:97–104. https://doi.org/10.1016/j.parkreldis.2020.04.011

    Article  PubMed  PubMed Central  Google Scholar 

  21. Lim TS, Lee PH, Kim HS, Yong SW (2009) White matter hyperintensities in patients with multiple system atrophy. J Neurol 256(10):1663–1670. https://doi.org/10.1007/s00415-009-5176-5

    Article  PubMed  Google Scholar 

  22. Kim JS, Oh YS, Lee KS, Kim YI, Yang DW, Goldstein DS (2012) Association of cognitive dysfunction with neurocirculatory abnormalities in early Parkinson disease. Neurology 79(13):1323–1331. https://doi.org/10.1212/WNL.0b013e31826c1acd

    Article  PubMed  PubMed Central  Google Scholar 

  23. Pilleri M, Facchini S, Gasparoli E, Biundo R, Bernardi L, Marchetti M et al (2013) Cognitive and MRI correlates of orthostatic hypotension in Parkinson’s disease. J Neurol 260(1):253–259. https://doi.org/10.1007/s00415-012-6627-y

    Article  PubMed  Google Scholar 

  24. Newman L, O’Connor JD, Romero-Ortuno R, Reilly RB, Kenny RA (2021) Supine hypertension is associated with an impaired cerebral oxygenation response to orthostasis: finding from the Irish longitudinal study on ageing. Hypertension 78(1):210–219. https://doi.org/10.1161/hypertensionaha.121.17111

    Article  CAS  PubMed  Google Scholar 

  25. Earle W, Kondo J, Kendrick KN, Turkson-Ocran RA, Ngo L, Cluett JL et al (2023) Association of supine hypertension versus standing hypotension with adverse events among middle-aged adults. Hypertension 80(11):2437-2446. https://doi.org/10.1161/hypertensionaha.123.21215

  26. de Heus RAA, Olde Rikkert MGM, Tully PJ, Lawlor BA, Claassen J (2019) Blood pressure variability and progression of clinical alzheimer disease. Hypertension 74(5):1172–1180. https://doi.org/10.1161/hypertensionaha.119.13664

    Article  PubMed  Google Scholar 

  27. Alves M, Caldeira D, Ferreira JJ (2023) Blood pressure variability in Parkinson’s disease patients—case control study. Clin Park Relat Disord 8:100191. https://doi.org/10.1016/j.prdoa.2023.100191

    Article  PubMed  PubMed Central  Google Scholar 

  28. Niehaus L, Böckeler GC, Kupsch A, Meyer BU (2002) Normal cerebral hemodynamic response to orthostasis in Parkinson’s disease. Parkinsonism Relat Disord 8(4):255–259. https://doi.org/10.1016/s1353-8020(01)00014-1

    Article  CAS  PubMed  Google Scholar 

  29. Angeli S, Marchese R, Abbruzzese G, Gandolfo C, Conti M, Gasparetto B et al (2003) Tilt-table test during transcranial Doppler monitoring in Parkinson’s disease. Parkinsonism Relat Disord 10(1):41–46. https://doi.org/10.1016/s1353-8020(03)00069-5

    Article  PubMed  Google Scholar 

  30. Gurevich T, Gur AY, Bornstein NM, Giladi N, Korczyn AD (2006) Cerebral vasomotor reactivity in Parkinson’s disease, multiple system atrophy and pure autonomic failure. J Neurol Sci 243(1–2):57–60. https://doi.org/10.1016/j.jns.2005.11.028

    Article  PubMed  Google Scholar 

  31. Pavy-Le Traon A, Hughson RL, Thalamas C, Galitsky M, Fabre N, Rascol O et al (2006) Cerebral autoregulation is preserved in multiple system atrophy: a transcranial Doppler study. Mov Disord 21(12):2122–2126. https://doi.org/10.1002/mds.21130

    Article  PubMed  Google Scholar 

  32. Novak V, Novak P, Spies JM, Low PA (1998) Autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 29(1):104–111. https://doi.org/10.1161/01.str.29.1.104

    Article  CAS  PubMed  Google Scholar 

  33. Indelicato E, Fanciulli A, Poewe W, Antonini A, Pontieri FE, Wenning GK (2015) Cerebral autoregulation and white matter lesions in Parkinson’s disease and multiple system atrophy. Parkinsonism Relat Disord 21(12):1393–1397. https://doi.org/10.1016/j.parkreldis.2015.10.018

    Article  PubMed  Google Scholar 

  34. Xing Y, Li Q, Xu E, Zeng J, Mei S, Hua Y (2022) Impaired cerebral autoregulation in parkinson’s disease: an orthostatic hypotension analysis. Front Neurol 13:811698. https://doi.org/10.3389/fneur.2022.811698

    Article  PubMed  PubMed Central  Google Scholar 

  35. Harms MP, Colier WN, Wieling W, Lenders JW, Secher NH, van Lieshout JJ (2000) Orthostatic tolerance, cerebral oxygenation, and blood velocity in humans with sympathetic failure. Stroke 31(7):1608–1614. https://doi.org/10.1161/01.str.31.7.1608

    Article  CAS  PubMed  Google Scholar 

  36. Low PA, Opfer-Gehrking TL, McPhee BR, Fealey RD, Benarroch EE, Willner CL et al (1995) Prospective evaluation of clinical characteristics of orthostatic hypotension. Mayo Clin Proc 70(7):617–622. https://doi.org/10.4065/70.7.617

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

There was no targeted funding for the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA

    Abhishek Lenka

  2. Department of Neurology, University of Utah, Salt Lake City, UT, USA

    Guillaume Lamotte

  3. Department of Neurology, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA

    Guillaume Lamotte

  4. Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA

    Paul Beach

Authors
  1. Abhishek Lenka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Guillaume Lamotte
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paul Beach
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Guillaume Lamotte.

Ethics declarations

Conflict of interest

Guillaume Lamotte received honoraria for his role as managing editor of the journal Clinical Autonomic Research.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lenka, A., Lamotte, G. & Beach, P. Asymptomatic orthostatic hypotension in synucleinopathies: to treat or not to treat?. Clin Auton Res 34, 25–29 (2024). https://doi.org/10.1007/s10286-023-01006-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10286-023-01006-z

Keywords

Search

Navigation