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Data availability
The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
References
Spallone V et al. (2011) Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev 27(7):639–653
Vinik AI et al. (2017) American Association of Clinical endocrinologists and American college of endocrinology position statement on testing for autonomic and somatic nerve dysfunction. Endocr Pract 23(12):1472–1478
Maser RE et al. (2003) The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care 26(6):1895–1901
Vinik AI et al. (2018) Cardiac autonomic neuropathy in diabetes: a predictor of cardiometabolic events. Front Neurosci 12:591
Menduni M et al. (2022) Clinical scoring systems for the risk of cardiovascular autonomic neuropathy in type 1 and type 2 diabetes: a simple tool. J Peripher Nerv Syst 27(4):259–270
Gastol J et al. (2020) Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy. Sci Rep 10(1):5554
Soedamah-Muthu SS et al. (2008) Relationship between risk factors and mortality in type 1 diabetic patients in Europe: the EURODIAB prospective complications study (PCS). Diabetes Care 31(7):1360–1366
Spallone V (2019) Update on the impact, diagnosis and management of cardiovascular autonomic neuropathy in diabetes: what is defined, what is new, and what is Unmet. Diabetes Metab J 43(1):3–30
Barboi A, Pocica S (2020) Somatic and autonomic findings in cancer-related base of the skull syndromes. Clin Auton Res 30(4):343–346
Freeman R et al. (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 21(2):69–72
Norcliffe-Kaufmann L et al. (2018) Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol 83(3):522–531
Fanciulli A et al. (2018) Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American autonomic society (AAS) and the European federation of autonomic societies (EFAS): endorsed by the European academy of neurology (EAN) and the European society of hypertension (ESH). Clin Auton Res 28(4):355–362
Vinik AI et al. (2018) “Cardiac autonomic neuropathy in diabetes: a predictor of cardiometabolic events,” (in eng). Front Neurosci 12:591. https://doi.org/10.3389/fnins.2018.00591
Araki T, Milbrandt J (2000) Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. J Neurosci 20(1):187–195
Gastol J et al. (2020) Epigenetic mechanism in search for the pathomechanism of diabetic neuropathy development in diabetes mellitus type 1 (T1DM). Endocrine 68:235–240. https://doi.org/10.1007/s12020-019-02172-9
Acknowledgements
The authors thank the medical assistants, nurses, neurologists, EMR Optimization, and Enterprise Data Warehouse programmers, administrators and research personnel at NorthShore University HealthSystem who contributed to the quality improvement and practice-based research initiative using the EMR. The authors are grateful to Dr. Ann K. Barlow, for her careful reading of the manuscript and insightful comments.
Funding
The authors acknowledge funding support from the Agency for Healthcare Research and Quality (R01HS024057) to DMM. The authors also acknowledge the generous support of the Auxiliary of NorthShore University HealthSystem with respect to the initial building of the polyneuropathy standardized clinical documentation support toolkit within the EMR.
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Contributions
AB, BC, RF, and KM contributed to conception and design. AB, SP, and KM contributed data. AN and AE contributed to data curation. DM, AB, RF, and KM contributed to establishment of the DodoNA project. DM, AB, and RF contributed to building the polyneuropathy toolkit. BC contributed statistical analyses. BC and AB drafted the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.
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Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Ethical approval
This study was performed in line with the principles of the Declaration of Helsinki. Approval (EH22-301) was obtained from the NorthShore University HealthSystem Institutional Review Board (NSUHS-IRB) in July 2022 for a retrospective review of patient-electronic-medical-record data stored in our Electronic Data Warehouse (EDW) without requiring additional patient consent, as these data were obtained in the course of routine clinical practice. Genetic analyses were limited to enrollees in The DodoNA project: DNA Predictions to Improve Neurological Health (EH10-139, NSUHS-IRB approved April 2011). DodoNA participants provided written informed consent for genotyping and EMR review.
Consent to participate
DodoNA participants signed the informed consent regarding study participation and publishing their data (anonymously) before inclusion in this study.
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Chase, B.A., Pocica, S., Frigerio, R. et al. Mortality risk factors in newly diagnosed diabetic cardiac autonomic neuropathy. Clin Auton Res 33, 903–907 (2023). https://doi.org/10.1007/s10286-023-00975-5
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DOI: https://doi.org/10.1007/s10286-023-00975-5