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A systematic review of the effects of transcutaneous auricular vagus nerve stimulation on baroreflex sensitivity and heart rate variability in healthy subjects

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Abstract

Purpose

This systematic review aimed to evaluate the effect of transcutaneous auricular vagus nerve stimulation on heart rate variability and baroreflex sensitivity in healthy populations.

Method

PubMed, Scopus, the Cochrane Library, Embase, and Web of Science were systematically searched for controlled trials that examined the effects of transcutaneous auricular vagus nerve stimulation on heart rate variability parameters and baroreflex sensitivity in apparently healthy individuals. Two independent researchers screened the search results, extracted the data, and evaluated the quality of the included studies.

Results

From 2458 screened studies, 21 were included. Compared with baseline measures or the comparison group, significant changes in the standard deviation of NN intervals, the root mean square of successive RR intervals, the proportion of consecutive RR intervals that differ by more than 50 ms, high-frequency power, low-frequency to high-frequency ratio, and low-frequency power were found in 86%, 75%, 69%, 47%, 36%, and 25% of the studies evaluating the effects of transcutaneous auricular vagus nerve stimulation on these indices, respectively. Baroreflex sensitivity was evaluated in six studies, of which a significant change was detected in only one. Some studies have shown that the worse the basic autonomic function, the better the response to transcutaneous auricular vagus nerve stimulation.

Conclusion

The results were mixed, which may be mainly attributable to the heterogeneity of the study designs and stimulation delivery dosages. Thus, future studies with comparable designs are required to determine the optimal stimulation parameters and clarify the significance of autonomic indices as a reliable marker of neuromodulation responsiveness.

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References

  1. Weir HK, Anderson RN, Coleman King SM, Soman A, Thompson TD, Hong Y et al (2016) Heart disease and cancer deaths - trends and projections in the United States, 1969–2020. Prev Chronic Dis 13:E157. https://doi.org/10.5888/pcd13.160211

    Article  PubMed  PubMed Central  Google Scholar 

  2. Xu J, Murphy SL, Kochanek KD, Arias E (2015) Mortality in the United States. NCHS Data Brief 2016(267):1–8

    Google Scholar 

  3. Greenland P, Knoll MD, Stamler J, Neaton JD, Dyer AR, Garside DB et al (2003) Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. Jama 290(7):891–7. https://doi.org/10.1001/jama.290.7.891

    Article  PubMed  Google Scholar 

  4. Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M et al (2019) Current directions in the auricular vagus nerve stimulation i - a physiological perspective. Front Neurosci 13:854. https://doi.org/10.3389/fnins.2019.00854

    Article  PubMed  PubMed Central  Google Scholar 

  5. Beekwilder JP, Beems T (2010) Overview of the clinical applications of vagus nerve stimulation. J Clin Neurophysiol. 27(2):130–8. https://doi.org/10.1097/WNP.0b013e3181d64d8a

    Article  CAS  PubMed  Google Scholar 

  6. Pellissier S, Dantzer C, Canini F, Mathieu N, Bonaz B (2010) Psychological adjustment and autonomic disturbances in inflammatory bowel diseases and irritable bowel syndrome. Psychoneuroendocrinology. 35(5):653–62. https://doi.org/10.1016/j.psyneuen.2009.10.004

    Article  PubMed  Google Scholar 

  7. Curtis BM, Oeefe JH Jr (2002) Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight or flight. Mayo Clin Proc 77:45–54

    Article  PubMed  Google Scholar 

  8. Antonino D, Teixeira AL, Maia-Lopes PM, Souza MC, Sabino-Carvalho JL, Murray AR et al (2017) Non-invasive vagus nerve stimulation acutely improves spontaneous cardiac baroreflex sensitivity in healthy young men: a randomized placebo-controlled trial. Brain Stimul 10(5):875–881. https://doi.org/10.1016/j.brs.2017.05.006

    Article  PubMed  Google Scholar 

  9. Clancy JA, Mary DA, Witte KK, Greenwood JP, Deuchars SA, Deuchars J (2014) Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity. Brain Stimul 7(6):871–877. https://doi.org/10.1016/j.brs.2014.07.031

    Article  PubMed  Google Scholar 

  10. Chen M, Wang S, Li X, Yu L, Yang H, Liu Q et al (2020) Non-invasive autonomic neuromodulation is opening new landscapes for cardiovascular diseases. Front Physiol 11:550578. https://doi.org/10.3389/fphys.2020.550578

    Article  PubMed  PubMed Central  Google Scholar 

  11. Naftchi NE (1990) Mechanism of autonomic dysreflexia. Contributions of catecholamine and peptide neurotransmitters. Ann N Y Acad Sci. 579:133–48. https://doi.org/10.1111/j.1749-6632.1990.tb48356.x

    Article  CAS  PubMed  Google Scholar 

  12. Chen M, Zhou X, Yu L, Liu Q, Sheng X, Wang Z et al (2016) Low-level vagus nerve stimulation attenuates myocardial ischemic reperfusion injury by antioxidative stress and antiapoptosis reactions in canines. J Cardiovasc Electrophysiol 27(2):224–31. https://doi.org/10.1111/jce.12850

    Article  PubMed  Google Scholar 

  13. Sheng X, Chen M, Huang B, Liu J, Zhou L, Bao M et al (2016) Cardioprotective effects of low-level carotid baroreceptor stimulation against myocardial ischemia-reperfusion injury in canine model. J Interv Card Electrophysiol 45(2):131–40. https://doi.org/10.1007/s10840-015-0094-1

    Article  PubMed  Google Scholar 

  14. Lopshire JC, Zipes DP (2014) Spinal cord stimulation for heart failure: preclinical studies to determine optimal stimulation parameters for clinical efficacy. J Cardiovasc Transl Res 7(3):321–9. https://doi.org/10.1007/s12265-014-9547-7

    Article  PubMed  Google Scholar 

  15. Zipes DP (2017) Ablation of atrial gangionated plexi to treat symptomatic sinus bradycardia. JACC Clin Electrophysiol 3(9):960–961. https://doi.org/10.1016/j.jacep.2017.02.010

    Article  PubMed  Google Scholar 

  16. Böhm M, Linz D, Urban D, Mahfoud F, Ukena C (2013) Renal sympathetic denervation: applications in hypertension and beyond. Nat Rev Cardiol 10(8):465–76. https://doi.org/10.1038/nrcardio.2013.89

    Article  PubMed  Google Scholar 

  17. Cha YM, Li X, Yang M, Han J, Wu G, Kapa SC et al (2019) Stellate ganglion block and cardiac sympathetic denervation in patients with inappropriate sinus tachycardia. J Cardiovasc Electrophysiol 30(12):2920–2928. https://doi.org/10.1111/jce.14233

    Article  PubMed  PubMed Central  Google Scholar 

  18. Soltani D, Samimi S, Vasheghani-Farahani A, Shariatpanahi SP, Abdolmaleki P, Madjid Ansari A (2023) Electromagnetic field therapy in cardiovascular diseases: a review of patents, clinically effective devices, and mechanism of therapeutic effects. Trends Cardiovasc Med 33(2):72–78. https://doi.org/10.1016/j.tcm.2021.10.006

    Article  PubMed  Google Scholar 

  19. Borges U, Pfannenstiel M, Tsukahara J, Laborde S, Klatt S, Raab M (2021) Transcutaneous vagus nerve stimulation via tragus or cymba conchae: are its psychophysiological effects dependent on the stimulation area? Int J Psychophysiol 161:64–75. https://doi.org/10.1016/j.ijpsycho.2021.01.003

    Article  PubMed  Google Scholar 

  20. De Couck M, Cserjesi R, Caers R, Zijlstra WP, Widjaja D, Wolf N et al (2017) Effects of short and prolonged transcutaneous vagus nerve stimulation on heart rate variability in healthy subjects. Auton Neurosci 203:88–96. https://doi.org/10.1016/j.autneu.2016.11.003

    Article  PubMed  Google Scholar 

  21. Borges U, Laborde S, Raab M (2019) Influence of transcutaneous vagus nerve stimulation on cardiac vagal activity: Not different from sham stimulation and no effect of stimulation intensity. PLoS One 14(10):e0223848. https://doi.org/10.1371/journal.pone.0223848

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj 372:n71. https://doi.org/10.1136/bmj.n71

    Article  PubMed  PubMed Central  Google Scholar 

  23. Higgins JP, Savović J, Page MJ, Sterne JA (2021) Revised Cochrane risk of bias tool for randomized trials (RoB 2) additional considerations for crossover trials. RoB2 Development Group [Internet]

  24. Sterne J A, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. bmj 366

  25. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ et al (2019) Cochrane handbook for systematic reviews of interventions. John Wiley & Sons

    Book  Google Scholar 

  26. Gauthey A, Morra S, van de Borne P, Deriaz D, Maes N, le Polain JB, de Waroux, (2020) Sympathetic effect of auricular transcutaneous vagus nerve stimulation on healthy subjects: a crossover controlled clinical trial comparing vagally mediated and active control stimulation using microneurography. Front Physiol. https://doi.org/10.3389/fphys.2020.599896

    Article  PubMed  PubMed Central  Google Scholar 

  27. Sinkovec M, Trobec R, Meglic B (2021) Cardiovascular responses to low-level transcutaneous vagus nerve stimulation. Auton Neurosci Basic Clin. https://doi.org/10.1016/j.autneu.2021.102851

    Article  Google Scholar 

  28. Vosseler A, Zhao D, Fritsche L, Lehmann R, Kantartzis K, Small DM et al (2020) No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men. Sci Rep 10(1):20466. https://doi.org/10.1038/s41598-020-77430-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. De Couck M, Cserjesi R, Caers R, Zijlstra WP, Widjaja D, Wolf N et al (2017) Effects of short and prolonged transcutaneous vagus nerve stimulation on heart rate variability in healthy subjects. Auton Neurosci Basic Clin 203:88–96. https://doi.org/10.1016/j.autneu.2016.11.003

    Article  Google Scholar 

  30. De Smet S, Ottaviani C, Verkuil B, Kappen M, Baeken C, Vanderhasselt MA (2023) Effects of non-invasive vagus nerve stimulation on cognitive and autonomic correlates of perseverative cognition. Psychophysiology. https://doi.org/10.1111/psyp.14250

    Article  PubMed  Google Scholar 

  31. Forte G, Favieri F, Leemhuis E, De Martino ML, Giannini AM, De Gennaro L et al (2022) Ear your heart: transcutaneous auricular vagus nerve stimulation on heart rate variability in healthy young participants. PeerJ 10:e14447. https://doi.org/10.7717/peerj.14447

    Article  PubMed  PubMed Central  Google Scholar 

  32. Geng D, Liu X, Wang Y, Wang J (2022) The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people. PLoS One 17(2):e0263833. https://doi.org/10.1371/journal.pone.0263833

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Keute M, Machetanz K, Berelidze L, Guggenberger R, Gharabaghi A (2021) Neuro-cardiac coupling predicts transcutaneous auricular vagus nerve stimulation effects. Brain Stimul 14(2):209–216. https://doi.org/10.1016/j.brs.2021.01.001

    Article  PubMed  Google Scholar 

  34. Kozorosky EM, Lee CH, Lee JG, Nunez Martinez V, Padayachee LE, Stauss HM (2022) Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin. Physiol Rep. https://doi.org/10.14814/phy2.15253

    Article  PubMed  PubMed Central  Google Scholar 

  35. Sclocco R, Garcia RG, Kettner NW, Fisher HP, Isenburg K, Makarovsky M et al (2020) Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation. Brain Stimul 13(4):970–978. https://doi.org/10.1016/j.brs.2020.03.011

    Article  PubMed  PubMed Central  Google Scholar 

  36. Shen LL, Sun JB, Yang XJ, Deng H, Qin W, Du MY et al (2022) Reassessment of the effect of transcutaneous auricular vagus nerve stimulation using a novel burst paradigm on cardiac autonomic function in healthy young adults. Neuromodulation 25(3):433–442. https://doi.org/10.1111/ner.13521

    Article  PubMed  Google Scholar 

  37. Villani V, Tsakiris M, Azevedo R (2019) Transcutaneous vagus nerve stimulation improves interoceptive accuracy. Neuropsychologia 134:107201

    Article  CAS  PubMed  Google Scholar 

  38. Zhu Y, Xu F, Sun C, Xu W, Li M, Gong Y et al (2022) Noninvasive transcutaneous auricular vagal nerve stimulation improves gastric slow waves impaired by cold stress in healthy subjects. Neuromodulation. https://doi.org/10.1016/j.neurom.2022.03.010

    Article  PubMed  PubMed Central  Google Scholar 

  39. Dalgleish AS, Kania AM, Stauss HM, Jelen AZ (2021) Occipitoatlantal decompression and noninvasive vagus nerve stimulation slow conduction velocity through the atrioventricular node in healthy participants. J Osteopath Med 121(4):349–359. https://doi.org/10.1515/jom-2020-0213

    Article  PubMed  Google Scholar 

  40. Gancheva S, Bierwagen A, Markgraf DF, Bönhof GJ, Murphy KG, Hatziagelaki E et al (2018) Constant hepatic ATP concentrations during prolonged fasting and absence of effects of Cerbomed Nemos® on parasympathetic tone and hepatic energy metabolism. Mol Metab 7:71–79. https://doi.org/10.1016/j.molmet.2017.10.002

    Article  CAS  PubMed  Google Scholar 

  41. Kania AM, Weiler KN, Kurian AP, Opena ML, Orellana JN, Stauss HM (2021) Activation of the cholinergic antiinflammatory reflex by occipitoatlantal decompression and transcutaneous auricular vagus nerve stimulation. J Osteopath Med 121(4):401–415. https://doi.org/10.1515/jom-2020-0071

    Article  PubMed  Google Scholar 

  42. Bretherton B, Atkinson L, Murray A, Clancy J, Deuchars S, Deuchars J (2019) Effects of transcutaneous vagus nerve stimulation in individuals aged 55 years or above: potential benefits of daily stimulation. Aging (Albany NY) 11(14):4836–4857

    Article  PubMed  Google Scholar 

  43. Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ (1987) Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 59(4):256–262

    Article  CAS  PubMed  Google Scholar 

  44. Nolan J, Batin PD, Andrews R, Lindsay SJ, Brooksby P, Mullen M et al (1998) Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation 98(15):1510–1516

    Article  CAS  PubMed  Google Scholar 

  45. Johansson M, Gao SA, Friberg P, Annerstedt M, Carlström J, Ivarsson T et al (2007) Baroreflex effectiveness index and baroreflex sensitivity predict all-cause mortality and sudden death in hypertensive patients with chronic renal failure. J Hypertens 25(1):163–168

    Article  CAS  PubMed  Google Scholar 

  46. La Rovere MT, Bigger JT, Marcus FI, Mortara A, Schwartz PJ (1998) Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. The Lancet 351(9101):478–484

    Article  Google Scholar 

  47. Jouven X, Empana J-P, Schwartz PJ, Desnos M, Courbon D, Ducimetière P (2005) Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 352(19):1951–1958

    Article  CAS  PubMed  Google Scholar 

  48. Kiviniemi AM, Tulppo MP, Hautala AJ, Perkiömäki JS, Ylitalo A, Kesäniemi YA et al (2014) Prognostic significance of impaired baroreflex sensitivity assessed from Phase IV of the Valsalva maneuver in a population-based sample of middle-aged subjects. Am J Cardiol 114(4):571–576

    Article  PubMed  Google Scholar 

  49. Mischel NA, Mueller PJ (2011) (In)activity-dependent alterations in resting and reflex control of splanchnic sympathetic nerve activity. J Appl Physiol 111(6):1854–1862

    Article  PubMed  PubMed Central  Google Scholar 

  50. Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J (2009) The sympathetic nervous system in heart failure: physiology, pathophysiology, and clinical implications. J Am Coll Cardiol 54(19):1747–1762

    Article  CAS  PubMed  Google Scholar 

  51. Shaffer FM, Ginsberg JP (2017) An overview of heart rate variability metrics and norms. Front Public Health 5:258

    Article  PubMed  PubMed Central  Google Scholar 

  52. Task Force of the European Society of Cardiology the North A Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 93(5):1043–1065

    Article  Google Scholar 

  53. Shaffer F, McCraty R, Zerr CL (2014) A healthy heart is not a metronome: an integrative review of the heart’s anatomy and heart rate variability. Front Psychol 5:1040

    Article  PubMed  PubMed Central  Google Scholar 

  54. Mertens A, Carrette S, Klooster D, Lescrauwaet E, Delbeke J, Wadman WJ et al (2022) Investigating the effect of transcutaneous auricular vagus nerve stimulation on cortical excitability in healthy males. Neuromodulation Technol Neural Interface 5(3):395–406

    Article  Google Scholar 

  55. Machetanz K, Berelidze L, Guggenberger R, Gharabaghi A (2021) Transcutaneous auricular vagus nerve stimulation and heart rate variability: analysis of parameters and targets. Auton Neurosci 236:102894

    Article  CAS  PubMed  Google Scholar 

  56. Umetani K, Singer DH, McCraty R, Atkinson M (1998) Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol 31(3):593–601

    Article  CAS  PubMed  Google Scholar 

  57. Messina G, Vicidomini C, Viggiano A, Tafuri D, Cozza V, Cibelli G et al (2012) Enhanced parasympathetic activity of sportive women is paradoxically associated to enhanced resting energy expenditure. Auton Neurosci 169(2):102–106

    Article  CAS  PubMed  Google Scholar 

  58. De Couck M, Mravec B, Gidron Y (2012) You may need the vagus nerve to understand pathophysiology and to treat diseases. Clin Sci 122(7):323–328

    Article  Google Scholar 

  59. Entschladen F, Drell TL, Lang K, Joseph J, Zaenker KS (2004) Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol 5(4):254–258

    Article  CAS  PubMed  Google Scholar 

  60. Haensel A, Mills PJ, Nelesen RA, Ziegler MG, Dimsdale JE (2008) The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology 33(10):1305–1312

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y et al (2008) Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. Cardiovasc Res 77(4):713–721

    Article  CAS  PubMed  Google Scholar 

  62. Vlcek M, Radikova Z, Penesova A, Kvetnansky R, Imrich R (2008) Heart rate variability and catecholamines during hypoglycemia and orthostasis. Auton Neurosci 143(1–2):53–57

    Article  CAS  PubMed  Google Scholar 

  63. Fallgatter AJ, Neuhauser B, Herrmann MJ, Ehlis AC, Wagener A, Scheuerpflug P et al (2003) Far field potentials from the brain stem after transcutaneous vagus nerve stimulation. J Neural Transm (Vienna) 110(12):1437–43. https://doi.org/10.1007/s00702-003-0087-6

    Article  CAS  PubMed  Google Scholar 

  64. Uradu A, Wan J, Doytchinova A, Wright KC, Lin AYT, Chen LS et al (2017) Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation. Heart Rhythm 14(7):964–971. https://doi.org/10.1016/j.hrthm.2017.03.030

    Article  PubMed  PubMed Central  Google Scholar 

  65. Shen LL, Sun JB, Yang XJ, Deng H, Qin W, Du MY et al (2021) Reassessment of the effect of transcutaneous auricular vagus nerve stimulation using a novel burst paradigm on cardiac autonomic function in healthy young adults. Neuromodulation 25(3):433–442. https://doi.org/10.1111/ner.13521

    Article  PubMed  Google Scholar 

  66. Barantke M, Krauss T, Ortak J, Lieb W, Reppel M, Burgdorf C et al (2008) Effects of gender and aging on differential autonomic responses to orthostatic maneuvers. J Cardiovasc Electrophysiol 19(12):1296–1303

    Article  PubMed  Google Scholar 

  67. Abhishekh HA, Nisarga P, Kisan R, Meghana A, Chandran S, Raju T et al (2013) Influence of age and gender on autonomic regulation of heart. J Clin Monit Comput 27:259–264

    Article  PubMed  Google Scholar 

  68. Almeida-Santos MA, Barreto-Filho JA, Oliveira JLM, Reis FP, da Cunha Oliveira CC, Sousa ACS (2016) Aging, heart rate variability and patterns of autonomic regulation of the heart. Arch Gerontol Geriatr 63:1–8

    Article  PubMed  Google Scholar 

  69. Koenig J, Thayer JF (2016) Sex differences in healthy human heart rate variability: a meta-analysis. Neurosci Biobehav Rev 64:288–310

    Article  PubMed  Google Scholar 

  70. Krames E, Peckham PH, Rezai AR (2018) Neuromodulation: comprehensive textbook of principles, technologies, and therapies. Academic Press

    Google Scholar 

  71. Polak T, Markulin F, Ehlis AC, Langer JB, Ringel TM, Fallgatter AJ (2009) Far field potentials from brain stem after transcutaneous vagus nerve stimulation: optimization of stimulation and recording parameters. J Neural Transm 116:1237–1242

    Article  PubMed  Google Scholar 

  72. Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M, et al. (2019) Current directions in the auricular vagus nerve stimulation I–a physiological perspective. Frontiers in neuroscience 854

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Author notes

  1. Bayan Azizi and Sepehr Sima contributed equally to this work.

Authors and Affiliations

  1. Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Danesh Soltani, Bayan Azizi, Kiarash Tavakoli, Negin Sadat Hosseini Mohammadi & Ali Vasheghani-Farahani

  2. Department of Psychology, University of Tehran, Tehran, Iran

    Sepehr Sima

  3. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran

    Kiarash Tavakoli & Negin Sadat Hosseini Mohammadi

  4. Control and Intelligent Processing Center of Excellence (CIPCE), Cognitive Systems Laboratory, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran

    Abdol-Hossein Vahabie

  5. Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran

    Abdol-Hossein Vahabie

  6. Department of Computer Engineering and Information Technology, Imam Reza International University, Mashhad, Iran

    Kaveh Akbarzadeh-Sherbaf

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  1. Danesh Soltani
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Soltani, D., Azizi, B., Sima, S. et al. A systematic review of the effects of transcutaneous auricular vagus nerve stimulation on baroreflex sensitivity and heart rate variability in healthy subjects. Clin Auton Res 33, 165–189 (2023). https://doi.org/10.1007/s10286-023-00938-w

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