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État de santé et qualité de vie à long terme après guérison d’un cancer traité durant l’enfance

Devenir des enfants guéris d’un cancer

Health status and quality of life of long term survivors of childhood cancer

  • Synthèse / Review Article
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Oncologie

Abstract

Survival of children treated for cancer has now reached 75%. Relapses are rare after five years of remission. Long term follow-up should also detect treatment related, late adverse effects. Repeated cardiac evaluations are necessary, due to cumulative dose-dependent cardiotoxicity of anthracycline. Endocrinological disorders are mainly related to radiotherapy or high dose chemotherapy. Bone mineral density can be altered. Cognitive function, academic level and social outcome of non-irradiated patients are usually normal. Incidence of second neoplasms is low, but some of them are related to previous treatments. One of the major ongoing treatment objective is to preserve the quality of life of cured patients. Improvement of patient’s information regarding late effects is also required.

Résumé

La survie des enfants traités pour un cancer est actuellement de l’ordre de 75 %. Les récidives sont rares après cinq ans de rémission. La surveillance à long terme est donc également orientée vers le dépistage d’éventuelles séquelles des traitements. La toxicité myocardique, dosedépendante, des anthracyclines justifie un suivi cardiologique à long terme. Les complications endocriniennes sont surtout liées à la radiothérapie ou aux chimiothérapies à haute dose. Des troubles de la minéralisation osseuse peuvent être observés. Au niveau cognitif, les enfants non irradiés ont généralement un parcours scolaire puis une insertion socioprofessionnelle normaux. La survenue, rare, d’une seconde pathologie néoplasique peut être favorisée par le traitement reçu. Améliorer l’information et préserver la qualité de vie (QDV) des patients guéris est un objectif primordial de la prise en charge actuelle des cancers de l’enfant.

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Authors and Affiliations

  1. Service d’hémato-oncologie pédiatrique, hôpital Armand-Trousseau, 26, avenue du Docteur-A.-Netter, F-75012, Paris, France

    M. -D. Tabone

  2. Service de pédiatrie, CHU-hôpital Nord de Saint-Étienne, F-42255, Saint-Étienne cedex 02, France

    C. Berger

  3. Département d’oncologie-pédiatrique, institut Curie, 26, rue d’Ulm, F-75005, Paris, France

    H. Pacquement

  4. Service d’oncohématologie-pédiatrique, hôpital de l’Archet, 151, route Saint-Antoine-de-Ginestière, F-06200, Nice, France

    M. Poirée

  5. Service d’oncologie-médicale, CHU André-Michallon, boulevard de la Chantourne, F-38043, Grenoble, France

    D. Plantaz

  6. Service de pédiatre, d’hématologie et d’oncologie-pédiatrique, hôpital de La Timone-Enfants, 264, rue Saint-Pierre, F-13005, Marseille, France

    G. Michel

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  1. M. -D. Tabone
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Correspondence to M. -D. Tabone.

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Tabone, M.D., Berger, C., Pacquement, H. et al. État de santé et qualité de vie à long terme après guérison d’un cancer traité durant l’enfance. Oncologie 13, 151–156 (2011). https://doi.org/10.1007/s10269-011-2002-3

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  • DOI: https://doi.org/10.1007/s10269-011-2002-3

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