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Research on correlations of miR-585 expression with progression and prognosis of triple-negative breast cancer

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Abstract

Triple-negative breast cancer is a special type of breast cancer, characterized by younger onset age, shorter survival period, higher malignant degree, higher mortality, recurrence and metastasis. Triple-negative breast cancer is more harmful to women's life and health, compared with other types of breast cancer. This paper mainly studied the role of miR-585 in triple-negative breast cancer. Real-time quantitative PCR was used to detect the expression of miR-585 in triple-negative breast cancer cell lines and tissues. Kaplan–Meier curve and Cox proportional hazards model analysis were used to investigate the prognostic value of miR-585 in triple-negative breast cancer. CCK-8 and Transwell assays were used to detect cell proliferation, invasion and migration. miR-585 was significantly down-regulated in triple-negative breast cancer cells and tissues. The low expression of miR-585 has been shown to be significantly associated with poor prognosis in triple-negative breast cancer patients. Abnormally low expression of miR-585 can promote cell proliferation, migration and invasion. Overall, abnormally low expression of miR-585 is associated with prognosis and progression of triple-negative breast cancer. miR-585 may serve as a prognostic biomarker for patients with triple-negative breast cancer and it is expected to be a new method and strategy for the treatment of triple-negative breast cancer.

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Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qinchun Road, Hangzhou, 310003, Zhejiang Province, P.R. China

    Minya Yao, Shuqian Wang, Luyan Chen, Bajin Wei & Peifen Fu

Authors
  1. Minya Yao
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  2. Shuqian Wang
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  3. Luyan Chen
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  4. Bajin Wei
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  5. Peifen Fu
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Contributions

MY and PF contributed to the study conception and design. Material preparation, data collection and analysis were performed by MY, SW, LC and BW. The first draft of the manuscript was written by MY and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Peifen Fu.

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The authors have no conflict of interest to declare that are relevant to the content of this article.

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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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The ethics committee of The First Affiliated Hospital, College of Medicine, Zhejiang University approved this study.

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The participant has consented to the submission of the case report to the journal.

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Yao, M., Wang, S., Chen, L. et al. Research on correlations of miR-585 expression with progression and prognosis of triple-negative breast cancer. Clin Exp Med 22, 201–207 (2022). https://doi.org/10.1007/s10238-021-00704-0

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  • DOI: https://doi.org/10.1007/s10238-021-00704-0

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