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Serum levels of anti-SRP54 antibodies reflect disease activity of necrotizing myopathy in a child treated effectively with combinatorial methylprednisolone pulses and plasma exchanges followed by intravenous cyclophosphamide

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Modern Rheumatology

Abstract

We describe the effectiveness of combinatorial therapy with plasma exchanges and methylprednisolone pulses followed by intravenous cyclophosphamide in a young girl with anti-signal recognition particle 54 (SRP54) antibody-associated myopathy. We also use a newly described quantitative assay to demonstrate the close association between the titers of anti-SRP54 antibodies and disease activity. This is the first report of a pediatric patient indicating that the serum levels of anti-SRP54 antibodies are also beneficial for monitoring the disease activity of progressive necrotizing myopathy.

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Acknowledgments

This work was supported in part by a grant from the Association Française Contre les Myopathies.

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Authors and Affiliations

  1. Department of Pediatrics, Yokohama City University, 3-9 Fukukura, Kanazawaku, Yokohama, 236-0006, Japan

    Mei Momomura, Takako Miyamae, Tomo Nozawa, Masako Kikuchi, Toshitaka Kizawa, Tomoyuki Imagawa & Shumpei Yokota

  2. Laboratory of Immunology, Inserm U905, University of Rouen and Rouen University Hospital, Rouen, France

    Laurent Drouot, Fabienne Jouen & Olivier Boyer

Authors
  1. Mei Momomura
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  2. Takako Miyamae
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  3. Tomo Nozawa
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  4. Masako Kikuchi
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  5. Toshitaka Kizawa
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  6. Tomoyuki Imagawa
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  7. Laurent Drouot
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  8. Fabienne Jouen
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  9. Olivier Boyer
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  10. Shumpei Yokota
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Corresponding author

Correspondence to Takako Miyamae.

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Momomura, M., Miyamae, T., Nozawa, T. et al. Serum levels of anti-SRP54 antibodies reflect disease activity of necrotizing myopathy in a child treated effectively with combinatorial methylprednisolone pulses and plasma exchanges followed by intravenous cyclophosphamide. Mod Rheumatol (2012). https://doi.org/10.1007/s10165-012-0792-9

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  • DOI: https://doi.org/10.1007/s10165-012-0792-9

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