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The differences in renal hemodynamic response following high-intensity exercise between younger and older males

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Abstract

Background

Renal blood flow (RBF) decreases with exercise, but this change is only temporary, and habitual exercise may be an effective method to improve renal function. The kidney shows structural and functional changes with aging, but it is unclear how aging affects the hemodynamic response of the kidneys to exercise. Therefore, we evaluated the differences in the hemodynamic response of the kidneys to high-intensity exercise between younger and older men.

Methods

Sixteen men (8 young and 8 older) underwent an incremental exercise test using a cycle ergometer with a 1-min warm up followed by exercise at 10–20 W/min until the discontinuation criteria were met. Renal hemodynamics were assessed before exercise, immediately after exercise, and at 60-min after exercise using ultrasound echo.

Results

High-intensity exercise significantly reduced RBF in both groups (younger: ∆  – 53 ± 16%, p = 0.0005; older: ∆  – 53 ± 19%, p = 0.0004). In the younger group, RBF returned to the pre-exercise level 60-min after exercise (∆  – 0.4 ± 5.7%, p > 0.9999). In contrast, RBF 60-min after exercise was significantly lower than that before exercise in the older group (∆  – 24 ± 19%, p = 0.0006). The older group had significantly lower RBF than younger adults 60-min after exercise (423 ± 32 vs. 301 ± 98 mL/min, p = 0.0283).

Conclusions

Our findings demonstrate that RBF following high-intensity exercise recovered 60-min after exercise in younger group, whereas RBF recovery was delayed in the older group.

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Acknowledgements

The authors acknowledge the contribution of the staff at Fukuoka University, who helped with the recruitment of participants. The authors thank the volunteers who participated in this study.

Funding

This work was supported by Japan Society for the Promotion of Science (JSPS) (Grant numbers: 22K11489 to S. K., and 15H03082 to Y.H.) and Fukuoka University Institute for Physical Activity, Fukuoka, Japan.

Author information

Authors and Affiliations

  1. Graduate School of Sports and Health Science, Fukuoka University, Fukuoka, Japan

    Shotaro Kawakami

  2. Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan

    Shotaro Kawakami, Shihoko Nakashima, Yoshinari Uehara, Yasuki Higaki & Ryoma Michishita

  3. The Fukuoka University Institute for Physical Activity, Fukuoka, Japan

    Shotaro Kawakami, Saki Kawakami, Ai Ito, Shihoko Nakashima, Yoshinari Uehara, Yasuki Higaki & Ryoma Michishita

  4. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan

    Tetsuhiko Yasuno & Kosuke Masutani

  5. Faculty of Fukuoka Medical Technology, Teikyo University, 6-22, Misaki-Machi, Omuta-Shi, Fukuoka, Japan

    Kazuko Kotoku

  6. Department of Rehabilitation, Fukuoka University Hospital, Fukuoka, Japan

    Kanta Fujimi & Takuro Matsuda

Authors
  1. Shotaro Kawakami
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  2. Tetsuhiko Yasuno
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  12. Ryoma Michishita
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Contributions

SK, TY, KK, SK, and AI performed experiments; SK analyzed data; SK, TY, KK, YH, and RM. interpreted results of experiments; SK prepared figures; SK Writing – original draft; SK, TY, KK, SK, AI, KF, TM, SN, KM, YU, YH, and RM Writing – review and editing; SK, TY, KK, SK, AI, KF, TM, SN, KM, YU, YH, and RM approved final version of manuscript and SK, TY, YH, and RM conceived and designed research.

Corresponding author

Correspondence to Ryoma Michishita.

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Conflict of interest

No conflicts of interest, financial or otherwise, are declared by the authors.

Ethical approval

The study protocol in this study complied with the Declaration of Helsinki and the principles of Good Clinical Practice and was approved by the Ethics Committee of Fukuoka University (21-07-M1, 16-4-01).

Informed consent

All potential risks and procedures were explained to the participants, who provided written informed consent in this study.

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Kawakami, S., Yasuno, T., Kotoku, K. et al. The differences in renal hemodynamic response following high-intensity exercise between younger and older males. Clin Exp Nephrol 27, 972–980 (2023). https://doi.org/10.1007/s10157-023-02381-7

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  • DOI: https://doi.org/10.1007/s10157-023-02381-7

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