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Knee extensor muscle strength and index of renal function associated with an exercise capacity of 5 metabolic equivalents in male chronic heart failure patients with chronic kidney disease

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Abstract

Background

The goal of the present study was to determine knee extensor muscle strength (KEMS) and degree of renal dysfunction associated with an exercise capacity of ≥5 metabolic equivalents (METs) in male chronic heart failure (CHF) patients with chronic kidney disease (CKD).

Methods

In this cross-sectional study of 75 male CHF patients with CKD (65.3 ± 11.6 years), we measured clinical characteristics, peak \( \dot{V}{\text{O}}_{2} \), estimated glomerular filtration rate (eGFR), and KEMS. Patients were divided into two groups by exercise capacity: ≥5 METs group (n = 41) and <5 METs group (n = 34). Cutoff values for KEMS and eGFR resulting in an exercise capacity of ≥5 METs were selected with ROC curves. Patients were divided into four groups according to cutoff values, and numbers of patients attaining an exercise capacity of ≥5 METs were compared between groups.

Results

Age was significantly higher although eGFR, Hb, and KEMS were lower in the <5 METs versus ≥5 METs group (P < 0.001). Multiple logistic regression analysis revealed a positive significant relation between KEMS and eGFR and exercise capacity of ≥5 METs. Exercise capacity of ≥5 METs was associated with KEMS of approximately 1.69 Nm/kg and an eGFR of 45.7 mL/min/1.73 m2. The number of patients attaining an exercise capacity of ≥5 METs in the patients who did not reach both cutoff values was significantly lower than that in any other patients (P < 0.001).

Conclusion

KEMS and eGFR may be useful indices for predicting attainment of exercise capacity of ≥5 METs in male CHF patients with CKD.

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Conflict of interest

All authors declare no conflicts of interest in relation to the work reported in this manuscript.

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Authors and Affiliations

  1. Department of Rehabilitation Medicine, Kawasaki Municipal Tama Hospital, Kawasaki, Kanagawa, Japan

    Chiharu Hotta

  2. Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, 2-16-1 Sugao, Miyamaeku, Kawasaki, Kanagawa, 216-8511, Japan

    Koji Hiraki, Satoshi Watanabe & Kazuhiro P. Izawa

  3. Division of Nephrology and Hypertension, Department of Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan

    Takashi Yasuda & Kenjiro Kimura

  4. Division of Cardiology, Department of Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan

    Naohiko Osada & Kazuto Omiya

Authors
  1. Chiharu Hotta
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  2. Koji Hiraki
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  3. Satoshi Watanabe
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  4. Kazuhiro P. Izawa
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  5. Takashi Yasuda
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  6. Naohiko Osada
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  7. Kazuto Omiya
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  8. Kenjiro Kimura
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Corresponding author

Correspondence to Kazuhiro P. Izawa.

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Hotta, C., Hiraki, K., Watanabe, S. et al. Knee extensor muscle strength and index of renal function associated with an exercise capacity of 5 metabolic equivalents in male chronic heart failure patients with chronic kidney disease. Clin Exp Nephrol 18, 313–319 (2014). https://doi.org/10.1007/s10157-013-0818-4

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  • DOI: https://doi.org/10.1007/s10157-013-0818-4

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