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Membranoproliferative glomerulonephritis in a girl and her mother

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Abstract

A girl and her mother were diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I. Microscopic hematuria and proteinuria presented at 9 years of age in the mother and at 14 years in the daughter. Both had persistent hypocomplementemia and were treated with steroids. When the mother was 40 years old, proteinuria was still continuing and creatinine clearance was 64.4 ml/min per 1.73 m2. When the daughter was 15 years old, microscopic hematuria was still continuing. To our knowledge, familial cases of MPGN in two generations have not been reported in Japan.

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References

  1. Power DA, Ng YC, Simpson JG. Familial incidence of C3 nephritic factor, partial lipodystrophy and membranoproliferative glomerulonephritis. Q J Med. 1990;75:387–98.

    PubMed  CAS  Google Scholar 

  2. Neary J, Dorman A, Campbell E, Keogan M, Conlon P. Familial membranoproliferative glomerulonephritis type III. Am J Kidney Dis. 2002;40:E1–6.

    Article  PubMed  Google Scholar 

  3. Sherwood MC, Pincott JR, Goodwin FJ, Dillon MJ. Dominantly inherited glomerulonephritis and an unusual skin disease. Arch Dis Child. 1987;62:1278–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Cooper M, McGraw ME, Unsworth DJ, Mathieson P. Familial mesangio-capillary glomerulonephritis with initial presentation as haemolytic uraemic syndrome. Nephrol Dial Transplant. 2004;19:230–3.

    Article  PubMed  Google Scholar 

  5. Bakkaloglu A, Soylemezoglu O, Tinaztepe K, Saatci U, Soylemezoglu F. Familial membranoproliferative glomerulonephritis. Nephrol Dial Transplant. 1995;10:21–4.

    PubMed  CAS  Google Scholar 

  6. Pussell BA, Bourke E, Nayef M, Morris S, Peters D. Complement deficiency and nephritis. A report of a family. Lancet. 1980;1:675–7.

    PubMed  CAS  Google Scholar 

  7. Berry PL, McEnery PT, McAdams AJ, West CD. Membranoproliferative glomerulonephritis in two sibships. Clin Nephrol. 1981;16:101–6.

    PubMed  CAS  Google Scholar 

  8. Bogdanovic RM, Dimitrijevic JZ, Nikolic VN, Ognjanovic MV, Rodic BD, Slavkovic BV. Membranoproliferative glomerulonephritis in two siblings: report and literature review. Pediatr Nephrol. 2000;14:400–5.

    Article  CAS  PubMed  Google Scholar 

  9. Ueda H, Isimura E, Okuno S, Maekawa K, Izumotani T, Kim M, et al. Sibling cases of nephritis resembling membranoproliferative glomerulonephritis (in Japanese with English abstract). Jpn J Nephrol. 2002;44:420–6.

    Google Scholar 

  10. Dobrin RS, Hoyer JR, Nevins TE, Sharp H, Gentry WC, Vernier RL. The association of familial liver disease, subepidermal immunoproteins, and membranoproliferative glomerulonephritis. J Pediatr. 1977;90:901–9.

    Article  CAS  PubMed  Google Scholar 

  11. Teisberg P, Grottum KA, Myhre E, Flatmark A. In-vivo activation of complement in hereditary nephropathy. Lancet. 1973;2:356–8.

    Article  CAS  PubMed  Google Scholar 

  12. Stutchfield PR, White RHR, Cameron AH, Thompson RA, Mackintosh P, Wells L. X-linked mesangiocapillary glomerulonephritis. Clin Nephrol. 1986;26:150–6.

    PubMed  CAS  Google Scholar 

  13. Murakami M, Tatsuma N, Tsugu H, Ambo K, Tsuchiya M, Yamamoto M, et al. Incidence of hypocomplementemia in elementary and junior high school children with urinary abnormalities. Acta Paediatr Jpn. 1997;39:413–5.

    Article  CAS  PubMed  Google Scholar 

  14. Reichel W, Kobberling J, Fischbach H, Scheler F. Membranoproliferative glomerulonephritis with partial lipodystrophy. Discordant occurrence in identical twins. Klin Wochenschr. 1976;54:75–81.

    Article  CAS  PubMed  Google Scholar 

  15. Iitaka K, Nakamura S, Moriya S, Koshino H, Iwanami N, Sakai T, et al. Hypocomplementemia and membranoproliferative glomerulonephritis in children. Clin Exp Nephrol. 2005;9:31–3.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan

    Osamu Motoyama

  2. Department of Nephrology, Toho University Medical Center, Omori Hospital, Tokyo, Japan

    Ken Sakai, Yasushi Ohashi & Sonoo Mizuiri

  3. Department of Pathology, Toho University Medical Center, Omori Hospital, Tokyo, Japan

    Tsutomu Hatori

  4. Department of Pediatrics, Social Insurance Sagamino Hospital, Kanagawa, Japan

    Kikuo Iitaka

  5. Department of Pediatrics, St Marianna University School of Medicine, Kanagawa, Japan

    Yasushi Koitabashi

Authors
  1. Osamu Motoyama
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  2. Ken Sakai
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  3. Yasushi Ohashi
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  4. Sonoo Mizuiri
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  5. Tsutomu Hatori
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  6. Kikuo Iitaka
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  7. Yasushi Koitabashi
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Corresponding author

Correspondence to Osamu Motoyama.

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Motoyama, O., Sakai, K., Ohashi, Y. et al. Membranoproliferative glomerulonephritis in a girl and her mother. Clin Exp Nephrol 13, 77–80 (2009). https://doi.org/10.1007/s10157-008-0070-5

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  • DOI: https://doi.org/10.1007/s10157-008-0070-5

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