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Spatial and temporal patterns of colorectal cancer in Asia, 1990–2019

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Abstract

Background

Asia accounts for the largest burden of colorectal cancer (CRC) worldwide. This study examines the temporal patterns of CRC in Asia in the last three decades.

Methods

The data pertaining to CRC burden measured by incidence, mortality, and disability-adjusted-life-years (DALYs) and its risk factors for 49 countries in the Asian continent were drawn from the Global Burden of Disease 2019 study between 1990 and 2019. Mortality-to-incidence ratio (MIR) was employed as a proxy indicator of 5-year survival rates.

Results

In Asia, incident cases more than tripled from 270,851 to 1.1 million, deaths tripled from 183,252 to 560,426, and DALYs more than doubled from 5 million to 13.4 million between 1990 and 2019. The age-standardized incidence rate (ASIR) increased from 14.0/100,000 to 23.9/100,000, age-standardized mortality rate (ASMR) increased from 10.1/100,000 to 12.5/100,000, and MIR decreased from 0.68 to 0.50 between 1990 and 2019. ASIR varied 10-folds across countries from 5.6/100,000 in Bangladesh to 62.0/100,000 in Taiwan in 2019 and ASMR from 4.9/1000 in Bangladesh to 30.3/100,000 in Brunei. In 2019, diet low in milk (18.7%) and whole grains (15.2%) and calcium (16.6%) were the major contributory risk factors in CRC DALYs in 2019.

Conclusion

CRC is a fast-rising neoplasm in Asia and its burden can be curtailed by focusing on primary prevention (e.g., diet and physical activity) and secondary prevention through screening. The policy focus and resources must be directed towards capacity building, including cancer infrastructure and quality data availability from cancer registries.

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Data availability

All data are procured from GBD Results Tool http://ghdx.healthdata.org/gbd-results-tool

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Acknowledgements

We thank Institute of Health Metrics and Evaluation for providing GBD 2019 estimates in the public domain.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Humanities and Social Sciences, National Institute of Technology Kurukshetra, Kurukshetra, India

    Rajesh Sharma

  2. Economics and Business Environment, Indian Institute of Management Jammu, Jammu and Kashmir, India

    Bijoy Rakshit

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Correspondence to Rajesh Sharma.

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The research was conducted using data available in the public domain and did not include any human participants or animals. Therefore, no ethical approvals were required.

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All the data used in this study are available in the public domain. The geographical maps in the manuscript are drawn using GADM in Python and do not reflect the author’s views on the geographical boundaries of the represented countries.

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Sharma, R., Rakshit, B. Spatial and temporal patterns of colorectal cancer in Asia, 1990–2019. Int J Clin Oncol 28, 255–267 (2023). https://doi.org/10.1007/s10147-022-02274-x

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