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Analyses of the association between cervical cancer and osteoporosis/osteoporotic fracture: a cross-sectional study using KoGES HEXA data

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Abstract

Background

This study aimed to evaluate the association between cervical cancer and the occurrence of osteoporosis and osteoporotic fracture using data from the Korean Genome and Epidemiology Study (KoGES).

Methods

In this national cohort study using KoGES health examination (HEXA) data, we extracted data for patients with cervical cancer (n = 493) and control participants (n = 77,571); we then analyzed the occurrence of osteoporosis and osteoporotic fracture at baseline from 2004 to 2013 and during follow-up from 2012 to 2016. A logistic regression model was used to analyze the odds ratios (ORs) and the 95% confidence intervals (CIs).

Results

The ORs (95% CIs) for osteoporosis and osteoporotic fracture were 1.49 (95% CI 1.15–1.92, p = 0.03) and 1.06 (95% CI 0.82–1.38, p = 0.634), respectively, in the cervical cancer group. The ORs (95% CIs) for osteoporosis were 2.12 (95% CI 1.14–3.95, p = 0.018) in the ≤ 51-year-old group and 1.43 (95% CI 1.08–1.89, p = 0.011) in the ≥ 52-year-old group of cervical cancer patients.

Conclusion

We concluded that Korean women with cervical cancer had a higher risk of osteoporosis than healthy women, but the same finding was not observed for osteoporotic fracture.

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Funding

This work was supported in part by a research grant (NRF-2018-R1D1A1A0-2085328) from the National Research Foundation (NRF) of Korea, and Hallym University Research Fund (HURF).

Author information

Authors and Affiliations

  1. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Republic of Korea

    Hyo Geun Choi, Chan Yang Min & Dae Myoung Yoo

  2. Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea

    Hyo Geun Choi

  3. Department of Orthopedic Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea

    Jung Woo Lee

  4. Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang, Gyeonggi, 14068, Republic of Korea

    Suk Woo Lee

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Corresponding author

Correspondence to Suk Woo Lee.

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Conflict of interest

Hyo Geun Choi declares that he has no conflict of interest. Jung Woo Lee declares that he has no conflict of interest. Chan Yang Min declares that she has no conflict of interest. Dae Myoung Yoo declares that he has no conflict of interest. Suk Woo Lee declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The requirement for written informed consent was waived by the Institutional Review Board of Hallym University because we were licensed to use KoGES health examinee data from Korean National Institute of Health.

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Choi, H.G., Lee, J.W., Min, C.Y. et al. Analyses of the association between cervical cancer and osteoporosis/osteoporotic fracture: a cross-sectional study using KoGES HEXA data. Int J Clin Oncol 26, 1752–1758 (2021). https://doi.org/10.1007/s10147-021-01951-7

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  • DOI: https://doi.org/10.1007/s10147-021-01951-7

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