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Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma

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Abstract

Backgroud

Laryngeal preservation is an important consideration when treating cervical esophageal cancers (CECs) such as laryngeal cancer. The standard treatment for CEC allowing laryngeal preservation is chemoradiotherapy. However, in cases of laryngeal cancer, chemoselection has also been applied as a treatment strategy that promotes larynx preservation. This strategy involves assigning the appropriate radical treatment according to the primary tumor’s response to induction chemotherapy. Since there have been no studies of the application of chemoselection in CEC cases, the present study compared the results, including laryngeal preservation rates, obtained upon applying chemoselection and chemoradiotherapy to CEC.

Study design

This was a retrospective cohort study of cervical esophageal squamous cell carcinoma patients treated using chemoselection or chemoradiotherapy at Aichi Cancer Center Hospital between January 2000 and March 2013. A total of 42 patients were enrolled.

Results

The 2-year overall survival and laryngeal preservation rates for the chemoselection group versus the primary radiotherapy group were 65.1 and 57.3 versus 40 and 83.3%, respectively (P = 0.017 and P = 0.122, respectively). The 2-year locoregional control rates for the chemoselection and primary radiotherapy groups were 68 and 25%, respectively (P = 0.045).

Conclusion

The chemoselection group achieved favorable results. Therefore, chemoselection can be applied as a treatment strategy for CEC.

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References

  1. Tachimori Y, Ozawa S, Numasaki H et al (2015) Comprehensive registry of esophageal cancer in Japan, 2008. Esophagus 12:130–157

    Article  Google Scholar 

  2. Nikbakhsh N, Saidi F, Fahimi H (2012) A new technical approach to cancers of the cervical esophagus. Arch Iran Med 15:298–302

    PubMed  Google Scholar 

  3. Grass GD, Cooper SL, Armeson K et al (2015) Cervical esophageal cancer: a population-based study. Head Neck 37:808–814. doi:10.1002/hed.23678

    Article  PubMed  Google Scholar 

  4. Mendenhall WM, Sombeck MD, Parsons JT et al (1994) Management of cervical esophageal carcinoma. Semin Radiat Oncol 4:179–191

    Article  CAS  PubMed  Google Scholar 

  5. National Comprehensive Cancer Network (2017) NCCN guideline, version 2. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed 3 Mar 2017

  6. Stahl M, Mariette C, Haustermans K et al (2013) Oesophageal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(Suppl 6):51–56. doi:10.1093/annonc/mdt342

  7. Vainshtein JM, Wu VF, Spector ME et al (2013) Chemoselection: a paradigm for optimization of organ preservation in locally advanced larynx cancer. Expert Rev Anticancer Ther 13:1053–1064. doi:10.1586/14737140.2013.829646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Worden FP, Moyer J, Lee JS et al (2009) Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion. Laryngoscope 119:1510–1517. doi:10.1002/lary.20294

    Article  PubMed  PubMed Central  Google Scholar 

  9. Urba S, Wolf G, Eisbruch A et al (2006) Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm. J Clin Oncol 24:593–598

    Article  CAS  PubMed  Google Scholar 

  10. Japan Esophageal Society (2015) Japanese classification of esophageal cancer, 11th English edn. Kanehara & Co. Ltd., Tokyo

  11. Charlson ME, Pompei P, Ales KL et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies; development and validation. J Chronic Dis 40:373–383

    Article  CAS  PubMed  Google Scholar 

  12. Stuschke M, Stahl M, Wilke H et al (1999) Induction chemotherapy followed by concurrent chemotherapy and high-dose radiotherapy for locally advanced squamous cell carcinoma of the cervical oesophagus. Oncology 57:99–105

    Article  CAS  PubMed  Google Scholar 

  13. Cao CN, Luo JW, Gao L et al (2014) Primary radiotherapy compared with primary surgery in cervical esophageal cancer. JAMA Otolaryngol Head Neck Surg 140:918–926. doi:10.1001/jamaoto.2014.2013

    Article  PubMed  Google Scholar 

  14. Schieman C, Wigle DA, Deschamps C et al (2013) Salvage resections for recurrent or persistent cancer of the proximal esophagus after chemoradiotherapy. Ann Thorac Surg 95:459–463. doi:10.1016/j.athoracsur.2012.10.028

    Article  PubMed  Google Scholar 

  15. The Department of Veterans Affairs Laryngeal Cancer Study Group (1991) Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 324:1685–1690

    Article  Google Scholar 

  16. Miyata H, Yamasaki M, Takahashi T et al (2013) Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. World J Surg 37:551–557. doi:10.1007/s00268-012-1875-7

    Article  PubMed  Google Scholar 

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Acknowledgements

We thank Dr. Taijiro Ozawa for helping to conceive this study.

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Authors and Affiliations

  1. Department of Head and Neck Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Hidenori Suzuki, Yusuke Koide, Yujiro Fukuda & Yasuhisa Hasegawa

  2. Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan

    Motoo Nomura

  3. Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, 464-8681, Japan

    Takeshi Kodaira

  4. Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan

    Yusuke Nakata & Takeshi Shimizu

Authors
  1. Yusuke Nakata
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  2. Nobuhiro Hanai
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  3. Daisuke Nishikawa
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  4. Hidenori Suzuki
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  5. Yusuke Koide
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  6. Yujiro Fukuda
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  7. Motoo Nomura
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  8. Takeshi Kodaira
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  9. Takeshi Shimizu
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  10. Yasuhisa Hasegawa
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Corresponding author

Correspondence to Yasuhisa Hasegawa.

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The authors declare that they have no conflict of interest.

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Nakata, Y., Hanai, N., Nishikawa, D. et al. Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma. Int J Clin Oncol 22, 1034–1041 (2017). https://doi.org/10.1007/s10147-017-1149-3

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  • DOI: https://doi.org/10.1007/s10147-017-1149-3

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