Abstract
This report describes the case of the youngest Japanese person to be diagnosed with endocervical clearcell adenocarcinoma. In September 2005, a 17-year-old female adolescent visited a physician because of vaginal bleeding. A cervical tumor was discovered, and the patient was referred to our outpatient department. Vaginal examination showed a bleeding tumor approximately 1.5 cm in size protruding from the cervical os. The cytological finding of the uterine cervix was positive for malignancy, and the histological diagnosis by punch biopsy was clear-cell adenocarcinoma of the uterine cervix. A radical abdominal hysterectomy and pelvic lymphadenectomy were performed on October 30. Macroscopic findings showed a tumor, 1.5 cm in diameter, growing from the right side of the uterine cervix. The pathological diagnosis was clear-cell adenocarcinoma of the cervix (PT1b1NR0M0). The patient was discharged from our hospital without any adjuvant therapy. No signs of recurrence have been detected in the 2-year follow up.
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References
Noller KL, Decker DG, Dockerty MB, et al. (1974) Mesonephric (clear cell) carcinoma of the vagina and cervix. A retrospective analysis. Obstet Gynecol 43:640–644
Blythe JG, Michael H, Hodel KA (1983) Colposcopic and pathologic features in two cases of DES-related vaginal clear-cell adenocarcinoma. J Reprod Med 28:137–145
Greenwald P, Barlow J, Nasca PC, Burnett W (1971) Vaginal cancer after maternal treatment with synthetic estrogens. N Engl J Med 285:390–392
Gilson MD, Dibona DD, Knab DR (1973) Clear cell adenocarcinoma in young females. Obstet Gynecol 41:494–500
Melnick S, Cole P, Anderson D, Herbst A (1971) Rates and risks of diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix. An update. N Engl J Med 316:514–516
Boyd J, Takahashi H, Waggoner SE, et al. (1996) Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero. Cancer 77:505–513
Pirog EC, Kleter B, Semra O, et al. (2000) Prevalence of human papilloma virus DNA in different histological subtypes of cervical adenocarcinoma. Am J Pathol 157:1055–1062
Hanselaar A, Van Loosbroek M, Schuurbiers O, et al. (1997) Clear cell adenocarcinoma of the vagina and cervix. An update of the Central Netherlands Registry showing twin age incidence peaks. Cancer 79:2229–2236
Herbst AL, Scully RE (1970) Adenocarcinoma of the vagina in adolescence. A report of seven cases including six clear-cell carcinomas (so-called mesonephromas). Cancer 25:745–757
Matias-Guiu X, Lerma E, Prat J (1997) Clear cell tumors of the female genital tract. Semin Diagn Pathol 14:233–239
Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878–881
Monaghan JM, Sirisena L (1978) Stilboestrol and vaginal clear-cell adenocarcinoma syndrome. BMJ 1:1588–1590
Seki H, Takada T, Sodemoto T, et al. (2003) A young woman with clear cell adenocarcinoma of the uterine cervix. Int J Clin Oncol 8:399–404
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Yabushita, H., Kanyama, K., Sekiya, R. et al. Clear-cell adenocarcinoma of the uterine cervix in a 17-year-old adolescent. Int J Clin Oncol 13, 552–554 (2008). https://doi.org/10.1007/s10147-008-0781-3
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DOI: https://doi.org/10.1007/s10147-008-0781-3