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Clinical application of diffusion tensor imaging and fiber tractography in the management of brainstem cavernous malformations: a systematic review

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Abstract

This study aimed to systematically review the literature to determine the clinical utility and perspectives of diffusion tensor imaging (DTI) in the management of patients with brainstem cavernous malformations (BSCMs). PubMed, Embase, and Cochrane were searched for English-language articles published until May 10, 2021. Clinical studies and case series describing DTI-based evaluation of patients with BSCMs were included. Fourteen articles were included. Preoperative DTI enabled to adjust the surgical approach and choose a brainstem safe entry zone in deep-seated BSCMs. Preoperatively lower fractional anisotropy (FA) of the corticospinal tract (CST) correlated with the severity of CST injury and motor deficits. Postoperatively increased FA and decreased apparent diffusion coefficient (ADC) corresponded with the normalization of the perilesional CST, indicating motor improvement. The positive (PPV) and negative predictive value (NPV) of qualitative DTI ranged from 20 to 75% and from 66.6 to 100%, respectively. The presence of preoperative and postoperative motor deficits was associated with a higher preoperative resting motor threshold (RMT) and lower FA. A higher preoperative CST score was indicative of a lower preoperative and follow-up Medical Research Council (MRC) grade. DTI facilitated the determination of a surgical trajectory with minimized risk of WMTs’ damage. Preoperative FA and RMT might indicate the severity of preoperative and postoperative motor deficits. Preoperative CST score can reliably reflect patients’ preoperative and follow-up motor status. Due to high NPV, normal CST morphology might predict intact neurological outcomes. Contrarily, sparse and relatively low PPV limits the reliable prediction of neurological deficits.

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The data generated during this study are available within the article. Datasets analyzed during the current study preparation are available from the corresponding author on reasonable request.

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  1. Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland

    Marta Rogalska

  2. Department of Pediatric Neurosurgery, Medical University of Silesia, Katowice, Poland

    Lukasz Antkowiak & Marek Mandera

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Final version of the manuscript has been approved by all authors. Study concept and design: MR. Data collection and interpretation: MR, LA. Writing the article: MR, LA. Critical manuscript revision: MR, LA, MM. Supervision: MM.

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Rogalska, M., Antkowiak, L. & Mandera, M. Clinical application of diffusion tensor imaging and fiber tractography in the management of brainstem cavernous malformations: a systematic review. Neurosurg Rev 45, 2027–2040 (2022). https://doi.org/10.1007/s10143-022-01759-7

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