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Comparison between local abdominal and transcutaneous tail vein photobiomodulation in experimental rat model of ulcerative colitis

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Abstract

Ulcerative colitis (UC) is a chronic autoimmune disease that impacts the quality of life, but current pharmacological treatments are limited. Photobiomodulation (PBM) is a light-based treatment that can be applied either locally or systemically. Here, we compare the effects of local and vascular PBM (VPBM) in an experimental rat model of UC. Male Wistar rats were induced with UC by rectal instillation of acetic acid and treated with either local abdominal PBM or VPBM to the tail vein using a 660-nm LED. The findings indicated that local PBM but not VPBM reduced intestinal histological scores. Both local and VPBM increased mucus production, decreased mast cell degranulation, and modulated TNF-α and IL-1 β levels in the intestines. Local PBM also affected the expression of the mRNAs for IL-6, TNF-α, and IFN-γ. In conclusion, we suggest that local PBM appears to be more promising than VPBM for treating UC. However, further research is needed to fully understand the mechanisms and to optimize the parameters of PBM for UC treatment.

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Funding

This study was sponsored by CNPq 302746/2020–0.

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Authors and Affiliations

  1. Post Graduate Program in Biophotonics Medicine, University Nove de Julho (UNINOVE), Rua Vergueiro, 239/245, São Paulo, SP, 01504-000, Brazil

    Virgínia Mendes Matias Rodrigues, Kelly Cristina Quintela Martins Bitencourt, Adriana Schapochnik, Vanessa de Souza, Marlon da Palma Cruz, Rebeca Boltes Cecatto, Maria Fernanda Setúlbal Destro Rodrigues & Adriana Lino-dos-Santos-Franco

  2. Department of Basic Science in Health, Faculty of Medical Sciences, Federal University of Cuiabá, Cuiabá, Brazil

    Amílcar Sabino Damazo

  3. Department of Biological Sciences, University Federal de São Paulo (UNIFESP), Diadema, Brazil

    Caroline Marcantonio Ferreira

  4. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa

    Michael R. Hamblin

Authors
  1. Virgínia Mendes Matias Rodrigues
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  2. Kelly Cristina Quintela Martins Bitencourt
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  3. Adriana Schapochnik
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  7. Caroline Marcantonio Ferreira
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  8. Rebeca Boltes Cecatto
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  9. Michael R. Hamblin
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  10. Maria Fernanda Setúlbal Destro Rodrigues
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  11. Adriana Lino-dos-Santos-Franco
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Contributions

VMMR, KCQMB, AS, VdeS, and MdaPC carried out the experiments. ASD performed histological study. ALdosSF and MFdeSSD wrote the manuscript. ALdosSF conceived and planned the experiments. RBC and MRH discussed the results and contributed to the revision of the manuscript.

Corresponding author

Correspondence to Adriana Lino-dos-Santos-Franco.

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Rodrigues, V.M.M., Bitencourt, K.C.Q.M., Schapochnik, A. et al. Comparison between local abdominal and transcutaneous tail vein photobiomodulation in experimental rat model of ulcerative colitis. Lasers Med Sci 38, 247 (2023). https://doi.org/10.1007/s10103-023-03910-2

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  • DOI: https://doi.org/10.1007/s10103-023-03910-2

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