Abstract
This study aims to investigate the effect of compound topical anesthetic (CTA) application combined with photobiomodulation therapy (PBMT) on the level of pain perceived during placement of miniscrews and 24 h post the procedure in the buccal side of the maxillary bone. This randomized, prospective, single-center, split-mouth, double-blinded study included 25 subjects (12 males and 13 females, aged 16 to 35). Two anesthetic techniques before implantation were performed including Profound gel +PBM with 980 nm diode laser and local anesthesia with 2% lidocaine hydrochloride. Then, the miniscrews with the size of 1.6 mm in diameter and 8 mm in length were placed with a hand driver in the buccal side of the maxillary bone. The pain immediately after miniscrew placement (T1), also 12 h (T2), and 24 h (T3) post the procedure were collected by visual analog scale (VAS). Data were analyzed by SPSS version 22. There were no statistically significant differences in mean VAS scores within or between CTA combined with PBMT or injection applications, immediately after miniscrew placement (P = 0.75), 12 h after miniscrew placement (P = 0.4), and 24 h after miniscrew placement (P = 1.0). Compound topical anesthetic combined with PBMT provided adequate local anesthesia for the placement of miniscrews in the buccal side of the maxillary bone.
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References
Kanomi R (1997) Mini-implant for orthodontic anchorage. J Clin Orthod 31:763–767
Baumgaertel S, Razavi MR, Hans MG (2008) Mini-implant anchorage for the orthodontic practitioner. Am J Orthod Dentofac Orthop 133(4):621–627
Antoszewska-Smith J, Sarul M, Łyczek J, Konopka T, Kawala B (2017) Effectiveness of orthodontic miniscrew implants in anchorage reinforcement during en-masse retraction: a systematic review and meta-analysis. Am J Orthod Dentofac Orthop 151(3):440–455
Alharbi F, Almuzian M, Bearn D (2019) Anchorage effectiveness of orthodontic miniscrews compared to headgear and transpalatal arches: a systematic review and meta-analysis. Acta Odontol Scand 77(2):88–98
Magkavali-Trikka P, Emmanouilidis G, Papadopoulos MA (2018) Mandibular molar uprighting using orthodontic miniscrew implants: a systematic review. Prog Orthod 19(1):1
Tepedino M, Cattaneo PM, Niu X, Cornelis MA (2020) Interradicular sites and cortical bone thickness for miniscrew insertion: a systematic review with meta-analysis. Am J Orthod Dentofac Orthop
Brandão LB, Mucha JN (2008) Grau de aceitação de mini-implantes por pacientes em tratamento ortodôntico: estudo preliminar. Revista Dental Press de Ortodontia e Ortopedia Facial 13(5):118–127
Buschang PH, Carrillo R, Ozenbaugh B, Rossouw PE (2008) 2008 survey of AAO members on miniscrew usage. J Clin Orthod 42(9):513
Mah J, Bergstrand F (2005) Temporary anchorage devices: a status report. J Clin Orthod 39(3):132
Kravitz ND, Kusnoto B (2006) Placement of mini-implants with topical anesthetic. J Clin Orthod 40(10):602
Baumgaertel S (2009) Compound topical anesthetics in orthodontics: putting the facts into perspective. Am J Orthod Dentofac Orthop 135(5):556–557
Graham JW (2006) Profound, needle-free anesthesia in orthodontics. J Clin Orthod 40(12):723
Lamberton JA, Oesterle LJ, Shellhart WC, Newman SM, Harrell RE, Tilliss T, Singh N, Carey CM (2016) Comparison of pain perception during miniscrew placement in orthodontic patients with a visual analog scale survey between compound topical and needle-injected anesthetics: a crossover, prospective, randomized clinical trial. Am J Orthod Dentofac Orthop 149(1):15–23
Valieri MM, Freitas KM, Valarelli FP, Cançado RH (2014) Comparison of topical and infiltration anesthesia for orthodontic mini-implant placement. Dental Press J Orthod 19(2):76–83
Ren C, McGrath C, Yang Y (2015) The effectiveness of low-level diode laser therapy on orthodontic pain management: a systematic review and meta-analysis. Lasers Med Sci 30(7):1881–1893
Giudice AL, Nucera R, Perillo L, Paiusco A, Caccianiga G (2019) Is low-level laser therapy an effective method to alleviate pain induced by active orthodontic alignment archwire? A randomized clinical trial. J Evid Based Dental Pract 19(1):71–78
Celebi F, Turk T, Bicakci AA (2019) Effects of low-level laser therapy and mechanical vibration on orthodontic pain caused by initial archwire. Am J Orthod Dentofac Orthop 156(1):87–93
Martins IP, Martins RP, Caldas SG, dos Santos-Pinto A, Buschang PH, Pretel H (2019) Low-level laser therapy (830 nm) on orthodontic pain: blinded randomized clinical trial. Lasers Med Sci 34(2):281–286
Cronshaw M, Parker S, Anagnostaki E, Lynch E (2019) Systematic review of orthodontic treatment management with photobiomodulation therapy. Photobiomodulation Photomed Laser Surg 37(12):862–868
Mizutani K, Musya Y, Wakae K, Kobayashi T, Tobe M, Taira K, Harada T (2004) A clinical study on serum prostaglandin E2 with low-level laser therapy. Photomed Laser Ther 22(6):537–539
Bicakci AA, Kocoglu-Altan B, Toker H, Mutaf I, Sumer Z (2012) Efficiency of low-level laser therapy in reducing pain induced by orthodontic forces. Photomed Laser Surg 30(8):460–465
Arias OR, Marquez-Orozco MC (2006) Aspirin, acetaminophen, and ibuprofen: their effects on orthodontic tooth movement. Am J Orthod Dentofac Orthop 130(3):364–370
Cronshaw M, Parker S, Arany P (2019) Feeling the heat: evolutionary and microbial basis for the analgesic mechanisms of photobiomodulation therapy. Photobiomodulation Photomed Laser Surg 37(9):517–526
Andrade Fdo S, Clark RM, Ferreira ML (2014) Effects of low-level laser therapy on wound healing. Rev Col Bras Cir 41(2):129–133. https://doi.org/10.1590/s0100-69912014000200010
Cronshaw M, Parker S, Anagnostaki E, Mylona V, Lynch E, Grootveld M (2020) Photobiomodulation and Oral Mucositis: a systematic review. Dentist J 8(3):87
Steven’s Pharmacy information sheet on PFG. Available at: http://stevensrx.com/files/INFORMATION%20SHEET%20ON%20PRO FOUND%20GEL%20UPDATED%20030509.pdf. Accessed July 15, 2014.
Cronshaw M, Parker S, Anagnostaki E, Mylona V, Lynch E, Grootveld M (2020) Photobiomodulation dose parameters in dentistry: a systematic review and meta-analysis. Dentist J 8(4):114
Sriwatanakul K, Kelvie W, Lasagna L, Calimlim JF, Weis OF, Mehta G (1983) Studies with different types of visual analog scales for measurement of pain. Clin Pharmacol Ther 34:234–239
Reznik DS, Jeske AH, Chen JW, English J (2009) Comparative efficacy of 2 topical anesthetics for the placement of orthodontic temporary anchorage devices. Anesth Prog 56(3):81–85
Flieger R, Gedrange T, Grzech-Leśniak K, Dominiak M, Matys J (2020) Low-level laser therapy with a 635 nm diode laser affects orthodontic mini-implants stability: a randomized clinical split-mouth trial. J Clin Med 9(1):112
Matys J, Flieger R, Gedrange T, Janowicz K, Kempisty B, Grzech-Leśniak K, Dominiak M (2020) Effect of 808 nm semiconductor laser on the stability of orthodontic micro-implants: a split-mouth study. Materials 13(10):2265
Meechan JG (2002) Effective topical anesthetic agents and techniques. Dent Clin N Am 46:759–766
Satpal SS, Sandu J (2013) Orthodontic pain: an interaction between age and sex in early and middle adolescence. Angle Orthod 83:966–972
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This study has been approved by ethical committee of Mazandaran University of Medical Sciences (approval code: IR.MAZUMS.REC.1399.427) and also was registered in the Iranian registry of clinical trial (IRCT20200616047801N1).
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Sobouti, F., Chiniforush, N., Saravani, H.J. et al. Efficacy of compound topical anesthesia combined with photobiomodulation therapy in pain control for placement of orthodontic miniscrew: a double-blind, randomized clinical trial. Lasers Med Sci 37, 589–594 (2022). https://doi.org/10.1007/s10103-021-03307-z
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DOI: https://doi.org/10.1007/s10103-021-03307-z