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Assessment of photobiomodulation therapy by an 8l0-nm diode laser on the reversal of soft tissue local anesthesia in pediatric dentistry: a preliminary randomized clinical trial

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Abstract

During the injection of local anesthesia in pediatric dental procedures, from the injection time until the elimination of tissue anesthesia, inevitable problems were reported. According to the encouraging results of previous studies addressing the positive effects of laser therapy on increasing the microcirculation, we aimed to investigate the clinical effect of photobiomodulation therapy on the reversal of soft tissue anesthesia in children. Using a split-mouth design, 34 children aged 4 to 8 years old, candidate for receiving local infiltration injection at both right and left side in mandible, were enrolled in the study. The mandibular right and left quadrants were randomly assigned to groups of laser or sham laser: in laser side, patients received 810-nm laser irradiation, and in the sham laser group, the patients had the laser in off mode at 45 min after injection with an interval of 7–10 days between two sessions of each quadrant treatments. The degree of anesthesia was evaluated using the palpation technique alternately every 15 min. Data were analyzed using paired sample t test and multiple linear regression test. The mean duration of anesthesia expressed in minutes was equal to 145.15 ± 23.27 and 188.82 ± 12.31 for the laser group and sham laser group, respectively. There was a significant difference in duration of anesthesia between two groups (P < 0.001). Considering the results and limitations of the present study, photobiomodulation therapy by 810-nm diode laser can be proposed as a non-invasive method in order to reduce the duration of anesthesia in pediatric patients.

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References

  1. Jastak JT, Yagiela JA (1983) Vasoconstrictors and local anesthesia: a review and rationale for use. J Am Dent Assoc 107:623–630. https://doi.org/10.14219/jada.archive.1983.0307

    Article  CAS  PubMed  Google Scholar 

  2. Staman NM, Townsend JA, Hagan JL (2013) Observational study: discomfort following dental procedures for children. Pediatr Dent 35:52–54

    PubMed  Google Scholar 

  3. College C, Feigal R, Wandera A, Strange M (2000) Bilateral versus unilateral mandibular block anesthesia in a pediatric population. Pediatr Dent 22:453–457

    CAS  PubMed  Google Scholar 

  4. Adewumi A, Hall M, Guelmann M, Riley J (2008) The incidence of adverse reactions following 4% septocaine (articaine) in children. Pediatr Dent 30:424–428

    CAS  PubMed  Google Scholar 

  5. Hersh EV, Hermann DG, Lamp CJ, Johnson PD, MacAfee KA (1995) Assessing the duration of mandibular soft tissue anesthesia. J Am Dent Assoc 126:1531–1536. https://doi.org/10.14219/jada.archive.1995.0082

    Article  CAS  PubMed  Google Scholar 

  6. Prados-Frutos JC, Rojo R, González-Serrano J, González-Serrano C, Sammartino G, Martínez González JM, Sánchez-Monescillo A (2015) Phentolamine mesylate to reverse oral soft-tissue local anesthesia:a systematic review and meta-analysis. J Am Dent Assoc 146:751–759.e3. https://doi.org/10.1016/j.adaj.2015.04.018

    Article  PubMed  Google Scholar 

  7. Hersh EV, Moore PA, Papas AS, Goodson JM, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults. J Am Dent Assoc 139:1080–1093. https://doi.org/10.14219/jada.archive.2008.0311

    Article  PubMed  Google Scholar 

  8. Walsh LJ (1997) The current status of low level laser therapy in dentistry. Part 1. Soft tissue applications. Aust Dent J 42:247–254. https://doi.org/10.1111/j.1834-7819.1997.tb00129.x

    Article  CAS  PubMed  Google Scholar 

  9. Genovese M, Olivi G (2008) Laser in paediatric dentistry: patient acceptance of hard and soft tissue therapy. Eur J Paediatr Dent 9:13–17

    CAS  PubMed  Google Scholar 

  10. Fekrazad R, Seraj B, Chiniforush N, Rokouei M, Mousavi N, Ghadimi S (2017) Effect of antimicrobial photodynamic therapy on the counts of salivary Streptococcus mutans in children with severe early childhood caries. Photodiagn Photodyn Ther 18:319–322. https://doi.org/10.1016/j.pdpdt.2017.03.007

    Article  CAS  Google Scholar 

  11. Fekrazad R, Seraj B, Ghadimi S, Tamiz P, Mottahary P, Dehghan MM (2015) The effect of low-level laser therapy (810 nm) on root development of immature permanent teeth in dogs. Lasers Med Sci 30:1251–1257. https://doi.org/10.1007/s10103-014-1588-2

    Article  PubMed  Google Scholar 

  12. Ghadimi S, Chiniforush N, Najafi M, Amiri S (2015) Excision of epulis granulomatosa with diode laser in 8 years old boy. J Lasers Med Sci 6:92–95

    PubMed  PubMed Central  Google Scholar 

  13. Chiniforush N, Ghadimi S, Yarahmadi N, Kamali A (2013) Treatment of Ankyloglossia with carbon dioxide (CO2) laser in a pediatric patient. J Lasers Med Sci 4:53–55

    PubMed  PubMed Central  Google Scholar 

  14. Wang X, Tian F, Reddy DD, Nalawade SS, Barrett DW, Gonzalez-Lima F, Liu H (2017) Up-regulation of cerebral cytochrome-c-oxidase and hemodynamics by transcranial infrared laser stimulation: a broadband near-infrared spectroscopy study. J Cereb Blood Flow Metab 37:3789–3802. https://doi.org/10.1177/0271678X17691783

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Wang X, Tian F, Soni SS, Gonzalez-Lima F, Liu H (2016) Interplay between up-regulation of cytochrome-c oxidase and hemoglobin oxygenation induced by near-infrared laser. Sci Rep 3:30540. https://doi.org/10.1038/srep30540

    Article  CAS  Google Scholar 

  16. de Freitas LF, Hamblin MR (2016) Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron 22:348–364. https://doi.org/10.1109/JSTQE.2016.2561201

    Article  CAS  Google Scholar 

  17. Hamblin MR (2018) Mechanisms and mitochondrial redox signaling in photobiomodulation. Photochem Photobiol 94:199–212. https://doi.org/10.1111/php.12864

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Gal D, Chokshi SK, Mosseri M, Clarke RH, Isner JM (1992) Percutaneous delivery of low-level laser energy reverses histamine-induced spasm in atherosclerotic Yucatan microswine. Circulation 85:756–768. https://doi.org/10.1161/01.CIR.85.2.756

    Article  CAS  PubMed  Google Scholar 

  19. Maegawa Y, Itoh T, Hosokawa T, Yaegashi K, Nishi M (2000) Effects of near-infrared low-level laser irradiation on microcirculation. Lasers Surg Med 27:427–437. https://doi.org/10.1002/1096-9101(2000)27:5<427::AID-LSM1004>3.0.CO;2-A

    Article  CAS  PubMed  Google Scholar 

  20. Kubota J (2002) Effects of diode laser therapy on blood flow in axial pattern flaps in the rat model. Lasers Med Sci 17:146–153. https://doi.org/10.1007/s101030200024

    Article  CAS  PubMed  Google Scholar 

  21. Laviola M, McGavin S, Freer G, Plancich G, Woodbury S, Marinkovich S et al (2008) Randomized study of phentolamine mesylate for reversal of local anesthesia. J Dent Res 87:635–639. https://doi.org/10.1177/154405910808700717

    Article  CAS  PubMed  Google Scholar 

  22. Jenkins PA, Carroll JD (2011) How to report low-level laser therapy (LLLT)/photomedicine dose and beam parameters in clinical and laboratory studies. Photomed Laser Surg 29:785–787. https://doi.org/10.1089/pho.2011.9895

    Article  PubMed  Google Scholar 

  23. Smith TA, Thompson JA, Lee WE (1993) Assessing patient pain during dental laser treatment. J Am Dent Assoc 124(92). https://doi.org/10.14219/jada.archive.1993.0037

    Article  CAS  PubMed  Google Scholar 

  24. Chi D, Kanellis M, Himadi E, Asselin ME (2008) Lip biting in a pediatric dental patient after dental local anesthesia: a case report. J Pediatr Nurs 23:490–493. https://doi.org/10.1016/j.pedn.2008.02.035

    Article  PubMed  PubMed Central  Google Scholar 

  25. Tavares M, Goodson JM, Studen-Pavlovich D, Yagiela JA, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. J Am Dent Assoc 139:1095–1104. https://doi.org/10.14219/jada.archive.2008.0312

    Article  PubMed  Google Scholar 

  26. Hersh EV, Lindemeyer R, Berg JH, Casamassimo PS, Chin J, Marberger A et al (2017) Phase four, randomized, double-blinded, controlled trial of phentolamine mesylate in two-to five-year-old dental patients. Pediatr Dent 39:39–45

    PubMed  Google Scholar 

  27. Daubländer M, Liebaug F, Niedeggen G, Theobald K, Kürzinger ML (2017) Effectiveness and safety of phentolamine mesylate in routine dental care. J Am Dent Assoc 148:149–156. https://doi.org/10.1016/j.adaj.2016.11.017

    Article  PubMed  Google Scholar 

  28. Michaud PL, Flood B, Brillant MS (2018) Reversing the effects of 2% lidocaine: a randomized controlled clinical trial. J Dent 72:76–79. https://doi.org/10.1016/j.jdent.2018.03.009

    Article  CAS  PubMed  Google Scholar 

  29. Helmi M, AlDosari M, Tavares M (2018) Phentolamine mesylate may be a safe and effective option to reduce discomfort and time to recovery after dental care with local anesthesia. J Evid Based Dent Pract 18:181–184. https://doi.org/10.1016/j.jebdp.2018.02.005

    Article  PubMed  Google Scholar 

  30. Caprioglio C, Olivi G, Genovese MD (2017) Paediatric laser dentistry. Part 1: general introduction. Eur J Paediatr Dent 18:80–82. https://doi.org/10.23804/ejpd.2017.18.01.17

    Article  CAS  PubMed  Google Scholar 

  31. Pick RM, Pecaro BC (1987) Use of the CO2 laser in soft tissue dental surgery. Lasers Surg Med 7:207–213. https://doi.org/10.1002/lsm.1900070213

    Article  CAS  PubMed  Google Scholar 

  32. Olmez A, Tuna D, Oznurhan F (2006) Clinical evaluation of diagnodent in detection of occlusal caries in children. J Clin Pediatr Dent 30:287–291

    PubMed  Google Scholar 

  33. Mathur VP, Dhillon JK, Kalra G (2014) A new approach to facilitate apexogenesis using soft tissue diode laser. Contemp Clin Dent 5:106. https://doi.org/10.4103/0976-237X.128683

    Article  PubMed  PubMed Central  Google Scholar 

  34. Gontijo I, Navarro RS, Haypek P, Ciamponi AL, Haddad AE (2005) The applications of diode and Er:YAG lasers in labial frenectomy in infant patients. J Dent Child (Chic) 72:10–15

    Google Scholar 

  35. Rai S, Kaur M, Bhatnagar P (2011) Laser: a powerful tool for treatment of pyogenic granuloma. J Cutan Aesthet Surg 4:144. https://doi.org/10.4103/0974-2077.85044

    Article  PubMed  PubMed Central  Google Scholar 

  36. Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL (2017) Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model. Free Radic Biol Med 113:157–164. https://doi.org/10.1016/j.freeradbiomed.2017.09.012

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Ihsan FM (2005) Low-level laser therapy accelerates collateral circulation and enhances microcirculation. Photomed Laser Surg 23:289–294. https://doi.org/10.1089/pho.2005.23.289

    Article  CAS  PubMed  Google Scholar 

  38. Uozumi Y, Nawashiro H, Sato S, Kawauchi S, Shima K, Kikuchi M (2010) Targeted increase in cerebral blood flow by transcranial near-infrared laser irradiation. Lasers Surg Med 42:566–576. https://doi.org/10.1002/lsm.20938

    Article  PubMed  Google Scholar 

  39. Yamany AA, sayed HM (2012) Effect of low level laser therapy on neurovascular function of diabetic peripheral neuropathy. J Adv Res 3:21–28. https://doi.org/10.1016/j.jare.2011.02.009

    Article  Google Scholar 

  40. Peplow PV, Baxter GD (2014) Defining a therapeutic window for laser irradiation (810 nm) applied to the inguinal region to ameliorate diabetes in diabetic mice. Photomed Laser Surg 32:500–504. https://doi.org/10.1089/pho.2014.3745

    Article  CAS  PubMed  Google Scholar 

  41. de Oliveira AR, Vanin AA, De Marchi T, Antonialli FC, Grandinetti VS, de Paiva PRV et al (2014) What is the ideal dose and power output of low-level laser therapy (810 nm) on muscle performance and post-exercise recovery? Study protocol for a double-blind, randomized, placebo-controlled trial. Trials 15:69. https://doi.org/10.1186/1745-6215-15-69

    Article  PubMed  PubMed Central  Google Scholar 

  42. Podogrodzki J, Lebiedowski M, Szalecki M, Kępa I, Syczewska M, Jóźwiak S (2016) Impact of low level laser therapy on skin blood flow. Dev Period Med 20:40–46

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Dental Research Center, Department of Pediatric Dentistry, Tehran University of Medical Science, Tehran, Iran

    Bahman Seraj

  2. Laser Research Center of Dentistry, Department of Pediatric Dentistry, Tehran University of Medical Sciences, Tehran, Iran

    Sara Ghadimi

  3. Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Neda Hakimiha

  4. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Javad Kharazifard

  5. Department of Pediatric Dentistry, Tehran University of Medical Sciences, Tehran, Iran

    Zahra Hosseini

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  5. Zahra Hosseini
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Correspondence to Zahra Hosseini.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the School of Dentistry, Tehran University of Medical Sciences (Approval ID: IR.TUMS.DENTISTRY.REC.1397.057) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Seraj, B., Ghadimi, S., Hakimiha, N. et al. Assessment of photobiomodulation therapy by an 8l0-nm diode laser on the reversal of soft tissue local anesthesia in pediatric dentistry: a preliminary randomized clinical trial. Lasers Med Sci 35, 465–471 (2020). https://doi.org/10.1007/s10103-019-02850-0

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