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Combined cytoreductive laser therapy and immunotherapy for palliation of metastatic renal cell carcinoma to the head and neck

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Abstract

Interleukin-2 (IL-2) remains the mainstay of treatment for metastatic renal cell carcinoma (RCC), but minimally invasive surgical techniques have provided new options for the combined treatment of RCC. Two patients with metastatic RCC to the head and neck treated by combined laser-induced thermal therapy and IL-2 were described in this case report. Both patients had an extended survival compared to the historical survival of 10 months for metastatic RCC but eventually succumbed to progressive disease. The authors’ initial experience with metastatic RCC suggests that laser thermoablation and immunotherapy in selected patients with metastatic RCC is warranted as a palliative treatment, but a larger study with long-term follow-up is necessary to determine the effectiveness of this approach.

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References

  1. Rohde D, Albers C, Mahnken A et al (2003) Regional thermoablation of local or metastatic renal cell carcinoma. Oncol Rep 10:753–757

    PubMed  Google Scholar 

  2. Paiva MB, Blackwell KE, Saxton RE et al (2002) Nd:YAG laser therapy for palliation of recurrent squamous cell carcinomas in the oral cavity. Lasers Surg Med 31:64–69

    Article  PubMed  Google Scholar 

  3. Brown DH (2000) The versatile contact Nd:YAG laser in head and neck surgery: an in vivo and clinical analysis. Laryngoscope 110:854–867

    Article  PubMed  CAS  Google Scholar 

  4. Paiva MB, Graeber IP, Castro DJ et al (1998) Laser and cisplatinum for treatment of human squamous cell carcinoma. Laryngoscope 108:1269–1276

    Article  PubMed  CAS  Google Scholar 

  5. Paiva M, Saxton R, Blackwell K et al (2000) Combined cisplatinum and laser thermal therapy for palliation of recurrent head and neck tumors. Diagn Ther Endosc 6:133–140

    Google Scholar 

  6. Gottlieb MD, Roland JT Jr (1998) Paradoxical spread of renal cell carcinoma to the head and neck. Laryngoscope 108:1301–1305

    Article  PubMed  CAS  Google Scholar 

  7. Simo R, Sykes AJ, Hargreaves SP et al (2000) Metastatic renal cell carcinoma to the nose and paranasal sinuses. Head Neck 22:722–727

    Article  PubMed  CAS  Google Scholar 

  8. Franklin JR, Figlin R, Rauch J et al (1996) Cytoreductive surgery in the management of metastatic renal cell carcinoma: the UCLA experience. Semin Urol Oncol 14:230–236

    PubMed  CAS  Google Scholar 

  9. Patard JJ, Leray E, Rioux-Leclercq N et al (2005) Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol 23:2763–2771

    Article  PubMed  Google Scholar 

  10. Campbell SC, Flanigan RC, Clark JI (2003) Nephrectomy in metastatic renal cell carcinoma. Curr Treatm Opt Oncol 4:363–372

    Google Scholar 

  11. Bex A, Horenblas S, de Gast GC (2003) The timing of immunotherapy and nephrectomy in multimodality treatment of metastatic renal cell carcinoma. Technol Cancer Res Treat 2:205–210

    PubMed  CAS  Google Scholar 

  12. Belldegrun A, Shvarts O, Figlin RA (2000) Expanding the indications for surgery and adjuvant interleukin-2-based immunotherapy in patients with advanced renal cell carcinoma. Cancer J Sci Am 6(Suppl 1):S88–S92

    PubMed  Google Scholar 

  13. Figlin RA (2000) Renal cell carcinoma: current status and future plans. Cancer J Sci Am 6(Suppl 1):S52–S54

    PubMed  Google Scholar 

  14. Owens RM, Friedman CD, Becker SP (1989) Renal cell carcinoma with metastasis to the parotid gland: case reports and review of the literature. Head Neck 11:174–178

    Article  PubMed  CAS  Google Scholar 

  15. Batson OV (1967) The vertebral system of veins as a means for cancer dissemination. Prog Clin Cancer 3:1–18

    PubMed  CAS  Google Scholar 

  16. Parnes RE, Goldberg SH, Sassani JW (1993) Renal cell carcinoma metastatic to the orbit: a clinicopathologic report. Ann Ophthalmol 25:100–102

    PubMed  CAS  Google Scholar 

  17. Rathmell WK, Godley PA (2004) Renal cell carcinoma. Curr Opin Oncol 16:247–252

    Article  PubMed  CAS  Google Scholar 

  18. Pantuck AJ (2005) Editorial on Hofmann et al: prognostic factors and survival after pulmonary resection of metastatic renal cell carcinoma. Eur Urol (in press)

  19. Dawson NA, Guo C, Zak R et al (2004) A phase II trial of gefitinib (Iressa, ZD1839) in stage IV and recurrent renal cell carcinoma. Clin Cancer Res 10:7812–7819

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

This study was supported by the Division of Head and Neck Surgery, the Jonsson Comprehensive Cancer, the UCLA School of Medicine, NIH-National Cancer Institute Grant # K23, CA 88921. The authors wish to acknowledge Dr. Thomas Calcaterra for his continued support for this research.

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Authors and Affiliations

  1. Division of Head and Neck Surgery, Department of Surgery, David Geffen School of Medicine-UCLA, 10833 Le Conte Avenue, CHS62-132, P.O. Box 162418, Los Angeles, CA, 90095-1624, USA

    M. B. Paiva, J. A. Sercarz, M. Polyakov, R. F. Canalis & D. J. Castro

  2. Division of Urology, Department of Surgery, David Geffen School of Medicine-UCLA, 10833 Le Conte Avenue, CHS62-132, Los Angeles, CA, 90095-1624, USA

    A. J. Pantuck

  3. Department of Medicine, David Geffen School of Medicine-UCLA, 10833 Le Conte Avenue, CHS62-132, Los Angeles, CA, 90095-1624, USA

    R. A. Figlin

Authors
  1. M. B. Paiva
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  2. J. A. Sercarz
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  3. A. J. Pantuck
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  4. M. Polyakov
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  5. R. A. Figlin
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  6. R. F. Canalis
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  7. D. J. Castro
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Corresponding author

Correspondence to M. B. Paiva.

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Paiva, M.B., Sercarz, J.A., Pantuck, A.J. et al. Combined cytoreductive laser therapy and immunotherapy for palliation of metastatic renal cell carcinoma to the head and neck. Lasers Med Sci 22, 60–63 (2007). https://doi.org/10.1007/s10103-006-0422-x

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  • DOI: https://doi.org/10.1007/s10103-006-0422-x

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