Abstract
The aim of this study was to evaluate the prevalence of latent Mycobacterium tuberculosis infection in hematopoietic stem cell transplantation candidates, using tuberculin skin test and QuantiFERON-TB Gold-Plus, in a high-burden tuberculosis country. Adult candidates for hematopoietic stem cell transplantation performed both tests before and those submitted to transplantation were followed up for 12 months. The prevalence of latent Mycobacterium tuberculosis infection was 17.1% and a moderate agreement between QuantiFERON-TB Gold-Plus and tuberculin skin test was observed in this population. Previous tuberculosis exposure was a risk factor for latent Mycobacterium tuberculosis infection. No cases of tuberculosis were diagnosed during follow-up period.
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All authors contributed to the study conception and design. Material preparation and data colletion were performed by Victor Augusto Camarinha de Castro Lima, Ana Paula Torres Santos, Jessica Fernandes Ramos, Livia Mariano, Priscila Musqueira, Natalya Zaidan Maluf, and Vanderson Rocha. Analysis was performed and the first draft of the manuscript was written by Victor Augusto Camarinha de Castro Lima and Silvia Figueiredo Costa. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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This study was approved by the Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo ethics committee, in accordance with the ethical standards of the Helsinki declaration, and informed consent was obtained from all included individuals.
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The authors declare no competing interests.
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Partial results of this study were submitted, accepted and presented as an abstract e-Poster (Number 4413) at 31st ECCMID, the European Congress of Clinical Microbiology and Infectious Diseases, that took place online on July 2021.
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Castro-Lima, V.A.C., Santos, A.P.T., Musqueira, P.T. et al. Prevalence of latent Mycobacterium tuberculosis infection in hematopoietic stem cell transplantation comparing tuberculin skin test and interferon-gamma release assay. Eur J Clin Microbiol Infect Dis 42, 899–902 (2023). https://doi.org/10.1007/s10096-023-04613-w
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DOI: https://doi.org/10.1007/s10096-023-04613-w