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Association between MMP16 rs60298754 and clinical phenotypes of Parkinson’s disease in southern Chinese

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Abstract

Study objectives

The aim was to investigate the association between MMP16 rs60298754 and symptoms of Parkinson’s disease (PD) in southern Chinese.

Methods

Seven hundred forty-five PD patients were recruited in this study. All patients were evaluated by Brief Pain Inventory (BPI), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson’s disease Questionnaire (PDQ-39), and MDS—Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded.

Results

The difference of BPI and Parkinson’s disease sleep scale (PDSS) between two groups was showed (BPI: MMP16 wildtypes: 14.73 ± 14.45; MMP16 carriers: 10.95 ± 10.67, p 0.002; PDSS: MMP16 wildtypes: 117.80 ± 21.45; MMP16 carriers: 108.40 ± 23.95, p < 0.001). The association of apathy, nocturia, and sensitive to light were found (apathy: p 0.001, OR: 0.49, 0.32—0.76; nocturia: p < 0.001, OR: 3.57, 1.90—7.26; sensitive to light: p < 0.001, OR: 3.99, 2.01—7.74).

Conclusions

MMP16 rs60298754 was associated with the presence of apathy, pain, nocturia, and sensitive to light.

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Acknowledgments

We thank all the patients who participated in this study.

Funding

This study was funded by the National Natural Science Foundation of China [grant numbers 81601010, 81701039, 81870843]; Young Excellent Talents in Tongji University (22120180604), Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai [Grant No. PWZxq2017-08] and the Outstanding Leaders Training Program of Pudong new area health system of Shanghai [Grant No. PWRl2018-01].

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Author notes

  1. Kui Chen, Meng-Ruo Guo, and Yue Zhang contributed equally to this work

Authors and Affiliations

  1. Department of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China

    Kui Chen

  2. Graduate School, Dalian Medical University, Dalian, Liaoning Province, 116044, China

    Meng-Ruo Guo

  3. Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China

    Yue Zhang, Gang Li & Bei Zhang

  4. Department of Neurology, Shanxi Provincial People’s Hospital, Shanxi Medical University, Taiyuan, China

    Yi Liu

Authors
  1. Kui Chen
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  2. Meng-Ruo Guo
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  4. Gang Li
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Contributions

Kui Chen and Meng-Ruo Guo collected the PD and control data, performed the statistical analysis and drafted the manuscript. Yue Zhang and Gang Li collected the PD data. Bei Zhang and Yi Liu designed the study, supervised the study, double-checked the statistical analysis and revised the manuscript.

Corresponding authors

Correspondence to Yi Liu or Bei Zhang.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the ethic committee of Shanghai East hospital. All participants signed consent forms.

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Chen, K., Guo, MR., Zhang, Y. et al. Association between MMP16 rs60298754 and clinical phenotypes of Parkinson’s disease in southern Chinese. Neurol Sci 42, 3211–3215 (2021). https://doi.org/10.1007/s10072-020-04894-5

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  • DOI: https://doi.org/10.1007/s10072-020-04894-5

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