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Taste changes in amyotrophic lateral sclerosis and effects on quality of life

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Abstract

The primary aim of the study is to evaluate possible taste changes in a cohort of amyotrophic lateral sclerosis patients (pALS) with dysphagia, focusing on eventual psychological and quality of life (QoL) implications. The second aim is to evaluate the changes of QoL following the use of a specific device that provides food flavour. Thirty-two ALS patients were recruited and divided into two groups: subjects feeding only through enteral tube (ET) and subjects still eating by oral way (OW). A specific set of questionnaires was selected and adapted to investigate possible changes of taste and the impact on psychological status and QoL. Moreover, a specific device that provides food flavours in a safety manner was applied to all patients. We found a perceived reduction of taste in ALS patients, in particular in the ET group. All patients showed a strong interest in the preservation of taste, and its loss negatively related to their QoL. The use of the flavour device improved the perceived QoL showing no side effects, even in the ET group. For the first time, our study revealed changes in taste perception in a cohort of ALS patients and the negative consequences that these changes have on psychological status and QoL. Furthermore, the positive effects of the device used to provide flavours suggest a possible rehabilitative effect, which should be better evaluated and confirmed in further studies.

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References

  1. Brown RH, Al-Chalabi A (2017) Amyotrophic lateral sclerosis. N Engl J Med 377(2):162–172

    Article  CAS  Google Scholar 

  2. Rowland LP, Shneider NA (2001) Amyotrophic lateral sclerosis. N Engl J Med 344:1688–1700

    Article  CAS  Google Scholar 

  3. Ruoppolo G, Schettino I, Frasca V, Giacomelli E, Prosperini L, Cambieri C, Roma R, Greco A, Mancini P, de Vincentiis M, Silani V, Inghilleri M (2013) Dysphagia in amyotrophic lateral sclerosis: prevalence and clinical findings. Acta Neurol Scand 128(6):397–401

    Article  CAS  Google Scholar 

  4. Muscaritoli M, Kushta I, Molfino A, Inghileri M, Sabatelli M et al (2012) Nutritional and metabolic support in patients with amyotrophic lateral sclerosis. Nutrition 28(10):959–966

    Article  Google Scholar 

  5. Onesti E, Schettino I, Gori MC, Frasca V, Ceccanti M et al (2017) Dysphagia in amyiotrophic lateral sclerosis: impact of patients behavior, diet adaptation and riluzole management. Front Neurol 8:94

    Article  Google Scholar 

  6. Chiocca JC, Olmos JA, Salis GB, Soifer LO, Higa R et al (2005) Prevalence, clinical spectrum and atypical symptoms of gastro-oesophageal reflux in Argentina: a nationwide population-based study. Aliment Pharmacol Ther 22(4):331–342

    Article  CAS  Google Scholar 

  7. Cho YS, Choi MG, Jeong JJ, Chung WC, Lee IS, Kim SW, Han SW, Choi KY, Chung IS (2005) Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea. Am J Gastroenterol 100(4):747–753

    Article  Google Scholar 

  8. Eslick GD, Talley NJ (2008) Dysphagia: epidemiology, risk factors and impact on quality of life—a population-based study. Aliment Pharmacol Ther 27(10):971–979

    Article  CAS  Google Scholar 

  9. Ruth M, Mansson I et al (1991) The prevalence of symptoms suggestive of esophageal disorders. Scand J Gastroenterol 26(1):73–81

    Article  CAS  Google Scholar 

  10. Watson DI, Lally CJ (2009) Prevalence of symptoms and use of medication for gastroesophageal reflux in an Australian community. World J Surg 33(1):88–94

    Article  Google Scholar 

  11. Ziolkowski BA, Pacholec A et al (2013) Objawy alarmowe, czynniki ryzyka wystąpienia raka przewodu pokarmowego i gotowość do udziału w endoskopowych badaniach przesiewowych. [Alarm symptoms, risk factors for digestive tract cancer and readiness to participate in an endoscopic screening program]. Prz Gastroenterol 8(2):108–114

    Google Scholar 

  12. Cho SY, Choung RS, Saito YA, Schleck CD, Zinsmeister AR, Locke GR III, Talley NJ (2015) Prevalence and risk factors for dysphagia: a USA community study. Neurogastroenterol Motil 27(2):212–219

    Article  CAS  Google Scholar 

  13. Katzberg HD, Benatar M (2011) Enteral tube feeding for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev 19(1):CD004030

    Google Scholar 

  14. Stavroulakis T, Walsh T, Shaw PJ, McDermott CJ et al (2013) Gastrostomy use in motor neurone disease (MND): a review, meta-analysis and survey of current practice. Amyotroph Lateral Scler Frontotemporal Degener 14(2):96–104

    Article  Google Scholar 

  15. Pellettier CA (2007) Chemosense, aging and oropharyngeal dysphagia: a review. Top Geriatr Rehabil 23(3):249–268

  16. Imoscopi A, Inelmen EM, Sergi G, Miotto F, Manzato E (2012) Taste loss in elderly: epidemiology, causes and consequences. Aging Clin Exp Res 24(6):570–579

    PubMed  Google Scholar 

  17. Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D et al (1999) The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci 169(1–2):13–21

  18. McGreevy J (2014) Characteristics of taste and smell alterations in patients treated for lung cancer: translation of and results using a symptom-specific questionnaire. Support Care Cancer 22(10):2635–2644

    Article  Google Scholar 

  19. Kanatas AN, Rogers SN (2004) A national survey of health-related quality of life questionnaires in head and neck oncology. Ann R Coll Surg Engl 86(1):6–10

    Article  CAS  Google Scholar 

  20. Kanatas AN, Mehanna HM, Lowe D, Rogers SN (2009) A second national survey of health-related quality of life questionnaires in head and neck oncology. Ann R Coll Surg Engl 91(5):420–425

    Article  Google Scholar 

  21. Ekberg O, Hamdy S, Woisard V, Wuttge-Hanning A et al (2001) Social and psychological burden of dysphagia: its impact on diagnosis and treatment. Dysphagia 17(2):139–146

    Article  Google Scholar 

  22. Heckmann JG, Stossel C, Lang CJG, Neundorfer B, Tomandl B, Hummel T (2005) Taste disorder in acute stroke. Stroke 36:1690–1694

    Article  Google Scholar 

  23. Kim JS, Choi-Kwon S, Kwon SU, Kwon JH (2009) Taste perception abnormalities after acute stroke in postmenopausal women. J Clin Neurosci 16:797–801

    Article  Google Scholar 

  24. Steinbach S, Hundt W, Vaitl A, Heinrich P, Förster S, Bürger K, Zahnert T (2010) Taste in mild cognitive impairment and Alzheimer’s disease. J Neurol 257:238–246

    Article  Google Scholar 

  25. Shah M, Deeb J, Fernando M, Noyce A, Visentin E, Findley LJ, Hawkes CH (2009) Abnormality of taste and smell in Parkinson’s disease. Parkinsonism Relat Disord 15:232–237

    Article  Google Scholar 

  26. Scinska A, Sienkiewicz-Jarosz H, Kuran W, Ryglewicz D et al (2004) Depressive symptoms and taste reactivity in humans (2004). Physiol Behav 82:899–904

    Article  CAS  Google Scholar 

  27. Maurer J, Hipp M, Schäfer C, Kölbl O (2011) Dysphagia. Impact on quality of life after radio(chemo)therapy of head and neck cancer. Strahlenther Onkol 187(11):744–749

    Article  Google Scholar 

  28. Vanderberghe-Descamps M, Sulmont-Rossè C, Septier C, Feron G et al (2017) Using food comfortability to compare food’s sensory characteristics expectations of elderly people with or without oral health problems. J Texture Stud 48(4):280–287

    Article  Google Scholar 

  29. Mazzini L, Corra T, Zaccala M, Mora G, Del Piano M et al (1995) Percutaneous endoscopic gastrostomy and enteral nutrition in amyotrophic lateral sclerosis. J Neurol 242(10):695–698

    Article  CAS  Google Scholar 

  30. Mitsumoto H, Davidson M, Moore D, Gad N, Brandis M, Ringel S, Rosenfeld J, Shefner JM, Strong MJ, Sufit R, Anderson FA, the ALS CARE Study Group (2003) Percutaneous endoscopic gastrostomy (PEG) in patients with ALS and bulbar dysfunction. Amyotroph Lateral Scler Other Motor Neuron Disord 4(3):177–185

    Article  CAS  Google Scholar 

  31. Padersen AM, Bardow A, Jensen SB et al (2002) Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis 8(3):117–129

    Article  Google Scholar 

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Authors and Affiliations

  1. Neuromuscular Omnicentre (NEMO)-Fondazione Serena Onlus, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy

    Claudia Tarlarini, Lucia Catherine Greco, Andrea Lizio, Francesca Gerardi, Valeria Ada Sansone & Christian Lunetta

  2. Neurorehabilitation Unit, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

    Valeria Ada Sansone

Authors
  1. Claudia Tarlarini
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  2. Lucia Catherine Greco
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  3. Andrea Lizio
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  4. Francesca Gerardi
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  5. Valeria Ada Sansone
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  6. Christian Lunetta
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Correspondence to Claudia Tarlarini.

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Tarlarini, C., Greco, L.C., Lizio, A. et al. Taste changes in amyotrophic lateral sclerosis and effects on quality of life. Neurol Sci 40, 399–404 (2019). https://doi.org/10.1007/s10072-018-3672-z

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  • DOI: https://doi.org/10.1007/s10072-018-3672-z

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