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Weight gain after subthalamic nucleus deep brain stimulation in Parkinson’s disease is influenced by dyskinesias’ reduction and electrodes’ position

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Abstract

Parkinson’s disease is a common neurodegenerative disease that can be treated with pharmacological or surgical therapy. Subthalamic nucleus (STN) deep brain stimulation is a commonly used surgical option. A reported side effect of STN-DBS is weight gain: the aim of our study was to find those factors that determine weight gain, through one year-long observation of 32 patients that underwent surgery in our centre. During the follow-up, we considered: anthropometric features, hormonal levels, motor outcome, neuropsychological and quality of life outcomes, therapeutic parameters and electrodes position. The majority (84%) of our patients gained weight (6.7 kg in 12 months); more than a half of the cohort became overweight. At 12th month, weight gain showed a correlation with dyskinesias reduction, electrodes voltage and distance on the lateral axis. In the multivariate regression analysis, the determinants of weight gain were dyskinesias reduction and electrodes position. In this study, we identified dyskinesias reduction and distance between the active electrodes and the third ventricle as determining factors of weight gain after STN-DBS implantation in PD patients. The first finding could be linked to a decrease in energy consumption, while the second one could be due to a lower stimulation of the lateral hypothalamic area, known for its important role in metabolism and body weight control. Weight gain is a common finding after STN-DBS implantation, and it should be carefully monitored given the potential harmful consequences of overweight.

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All authors have participated in the research and/or article preparation.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Neurology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20123, Milan, MI, Italy

    Roberta Balestrino, Damiano Baroncini, Mario Fichera, Giancarlo Comi & Maria Antonietta Volontè

  2. Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Torino, Italy

    Roberta Balestrino

  3. Department of Neurosurgery and Gamma Knife Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, MI, Italy

    Carmine Antonio Donofrio, Alberto Franzin & Pietro Mortini

Authors
  1. Roberta Balestrino
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  2. Damiano Baroncini
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  3. Mario Fichera
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  4. Carmine Antonio Donofrio
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  5. Alberto Franzin
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Correspondence to Maria Antonietta Volontè.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by San Raffaele Hospital ethical committee. Informed consent was obtained from all individual participants included in the study. No participants’ identifying information is included in this study.

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Balestrino, R., Baroncini, D., Fichera, M. et al. Weight gain after subthalamic nucleus deep brain stimulation in Parkinson’s disease is influenced by dyskinesias’ reduction and electrodes’ position. Neurol Sci 38, 2123–2129 (2017). https://doi.org/10.1007/s10072-017-3102-7

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  • DOI: https://doi.org/10.1007/s10072-017-3102-7

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