Abstract
Monocyte chemoattractant protein-1 (MCP-1) and its receptor CC chemokine receptor-2 (CCR2) play important roles in neuroinflammation and they have been shown to be involved in Parkinson’s disease (PD) pathogenesis. In addition, several studies have suggested a role for the MCP-1 and CCR2 genotypes in cognitive impairment and depression, which are common non-motor symptoms in PD patients. In this study, a cohort of 521 PD patients and 556 cases of healthy controls were recruited to investigate the association between the MCP-1 2518A/G (rs1064211) and CCR2 V64I (rs1799864) gene polymorphisms and PD risk in the Chinese population. We also analyze the influence of these genotypes on the cognitive function and depression in PD patients by comparing Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Wechsler Adult Intelligence Scale-Chinese Revision (WAIS-RC), Wechsler Memory Scale-Chinese Revision (WMS-RC) and Hamilton Depression Rating Scale (HAMD) ratings in 217 PD patients. Our results showed no significant differences in the genotype frequency between the PD group and the control group (P > 0.05). In addition, we also failed to find an influence of the MCP-1 and CCR2 genotypes on MMSE scores, MoCA scores, WAIS-RC scores, WMS-RC scores and HAMD scores in PD patients (P > 0.05). The MCP-1 and CCR2 gene polymorphisms may not be genetic risk factors for PD in the Han Chinese population, and they do not appear to influence cognitive function and depression in PD patients.
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Acknowledgments
The authors thank all the subjects who kindly agreed to participate in this study. This work is supported by grants from the National Natural Science Foundation of China (No. 81371401, No. 30801219), Natural Science Foundation of Guangdong Province, China (No. S2013010014033), Science and Technology Planning Project of Guangdong Province, China (No. 2013B021800199) and Science and Technology Program of Guangzhou, China (No. 2014J4100083, No. 2013J4100068).
Conflict of interest
The authors declare that they have no conflict of interest. Written informed consents were obtained from all subjects before their participation. The study was approved by the Ethics Committee of Guangdong General Hospital.
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L. Gao, H. Tang have contributed equally to this work.
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Gao, L., Tang, H., Nie, K. et al. MCP-1 and CCR2 gene polymorphisms in Parkinson’s disease in a Han Chinese cohort. Neurol Sci 36, 571–576 (2015). https://doi.org/10.1007/s10072-014-1990-3
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DOI: https://doi.org/10.1007/s10072-014-1990-3