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Excessive blinking as an initial manifestation of juvenile Huntington’s disease

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Abstract

Juvenile Huntington’s disease (JHD) is mostly characterized by rigidity, myoclonus, bradykinesia, dystonia and seizure. We report a 9-year-old male JHD patient presenting excessive blinking as the initial symptom two years prior to typical JHD symptoms. Genetic analysis revealed expansion of 108 CAG repeats and magnetic resonance imaging showed caudate atrophy with lateral ventricular enlargement.

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Authors and Affiliations

  1. Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou, 510080, China

    Shihui Xing, Ling Chen, Zhong Pei, Jinsheng Zeng & Jinru Li

  2. Stroke Center, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    Shihui Xing, Ling Chen, Zhong Pei & Jinsheng Zeng

  3. Department of Rehabilitation, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    Xi Chen

Authors
  1. Shihui Xing
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  2. Ling Chen
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  3. Xi Chen
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  4. Zhong Pei
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  5. Jinsheng Zeng
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  6. Jinru Li
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Correspondence to Jinsheng Zeng.

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Xing, S., Chen, L., Chen, X. et al. Excessive blinking as an initial manifestation of juvenile Huntington’s disease. Neurol Sci 29, 275–277 (2008). https://doi.org/10.1007/s10072-008-0981-7

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  • DOI: https://doi.org/10.1007/s10072-008-0981-7

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