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Lithium chloride’s inhibition of 3T3-L1 cell differentiation by regulating the Wnt/β-catenin pathway and enhancing villin 2 expression

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Abstract

The aim of this study is to reveal the relation among villin 2, Wnt/β-catenin, and adipogenesis by adding appropriate lithium chloride (LiCl). The study comprises three parts: the selection of LiCl concentration, the effect of LiCl on adipocyte differentiation during and after differentiation induction. By comprehensively analyzing the results of the experiments, we proved that LiCl can inhibit adipocyte differentiation and enhance villin 2 and β-catenin expressions not only during differentiation induction but also after it. Moreover, villin 2 has a significant impact on β-catenin. We suggest that villin 2 may participate in Wnt/β-catenin signaling.

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Authors and Affiliations

  1. Department of Animal Science, College of Animal Sciences, Jilin University, Changchun, 130062, China

    Yu-Yang Chi, Jing-Lin Shen, Jing Zhang, Shu-Ling Niu, Chang-Hai Zhou & Yong-Cheng Jin

  2. Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, China

    An-Shan Shan

  3. Department of Animal Science & Technology, College of Animal Bioscience & Technology, Konkuk University, Seoul, 05029, Korea

    Hong-Gu Lee

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  1. Yu-Yang Chi
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Correspondence to Yong-Cheng Jin.

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Chi, YY., Shen, JL., Zhang, J. et al. Lithium chloride’s inhibition of 3T3-L1 cell differentiation by regulating the Wnt/β-catenin pathway and enhancing villin 2 expression. Food Sci Biotechnol 25, 1147–1153 (2016). https://doi.org/10.1007/s10068-016-0183-7

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  • DOI: https://doi.org/10.1007/s10068-016-0183-7

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