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Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway

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Abstract

Xanthigen, a mixture of brown seaweed and pomegranate seed extracts, has weight loss properties and lipid-lowering effects in mice and humans. This study elucidated the Xanthigen mechanism of an anti-obesity activity in high-fat diet (HFD)-fed mice. Xanthigen decreased expression of peroxisome proliferator-activated receptor γ (PPARγ) in the adipose tissue of HFD-fed mice. The serum leptin level and the adipose tissue leptin expression in mice fed HFD plus Xanthigen were significantly decreased, compared to HFD-fed mice. Phosphorylation of AMPactivated protein kinase (AMPK) α and β and acetyl-CoA carboxylase (ACC) in the adipose tissue of HFD plus Xanthigen-fed mice was elevated, and HMG-CoA reductase (HMGCR) expression was decreased. Xanthigen may have an anti-obesity activity by down-regulation of PPARγ and activation of the AMPK pathway.

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Authors and Affiliations

  1. College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, 361-763, Korea

    Kyeong-Mi Choi, Young Soo Jeon, Wonkyun Kim, Anna Lee, Yong-Gil Kim, Ju Hyun Lee, Young Eun Kang, Mi Kyeong Lee & Hwan-Soo Yoo

  2. NOVAREX Co., Ltd., Life Science Institute, Ochang, Chungbuk, 363-885, Korea

    Jae-Chul Jung, Jeongrai Lee, Bokkee Min & Suk Hyung Kwon

  3. P.L.Thomas & Co., Inc., Morristown, New Jersey, 07960, USA

    Barbara Davis

Authors
  1. Kyeong-Mi Choi
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  2. Young Soo Jeon
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  3. Wonkyun Kim
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  4. Anna Lee
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  5. Yong-Gil Kim
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  6. Ju Hyun Lee
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  7. Young Eun Kang
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  8. Jae-Chul Jung
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  9. Jeongrai Lee
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  11. Suk Hyung Kwon
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  12. Barbara Davis
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  13. Mi Kyeong Lee
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  14. Hwan-Soo Yoo
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Correspondence to Hwan-Soo Yoo.

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Choi, KM., Jeon, Y.S., Kim, W. et al. Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway. Food Sci Biotechnol 23, 931–935 (2014). https://doi.org/10.1007/s10068-014-0125-1

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  • DOI: https://doi.org/10.1007/s10068-014-0125-1

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