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Chinese quince (Chaenomeles sinensis) extract inhibits cell migration and cytokine release in HMC-1 cells

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Abstract

Chinese quince (Chaenomeles sinensis; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were examined. CS extract inhibited HMC-1 cell migration in response to stem cell factor (SCF). Its mechanism is involved in the inhibition of a surface expression of c-kit binding to SCF. Tumor necrosis factor (TNF)-α expression is induced by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI). CS extract inhibited the TNF-α expression by blocking the activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and c-Jun-N-terminal kinase (JNK) in HMC-1 cells. CS extract suppressed the expression of interlukin (IL)-6, IL-8, and MCP-1 in human monocytic THP-1 cells, as well as the secretion of IL-6 in human keratinocytic HaCaT cells.

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Authors and Affiliations

  1. Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon, 301-746, Korea

    Do Hyung Kim & In Sik Kim

  2. Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan, 570-750, Korea

    Ji-Sook Lee

  3. Department of Biology, College of Natural Sciences, Daejeon University, Daejeon, 300-716, Korea

    Chi-Young Yun

  4. Department of Pathology, College of Oriental Medicine, Daejeon University, Daejeon, 300-716, Korea

    Dong-Hee Kim

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  1. Do Hyung Kim
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  2. Ji-Sook Lee
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  3. Chi-Young Yun
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  4. Dong-Hee Kim
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  5. In Sik Kim
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Correspondence to In Sik Kim.

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Kim, D.H., Lee, JS., Yun, CY. et al. Chinese quince (Chaenomeles sinensis) extract inhibits cell migration and cytokine release in HMC-1 cells. Food Sci Biotechnol 22, 501–506 (2013). https://doi.org/10.1007/s10068-013-0107-8

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  • DOI: https://doi.org/10.1007/s10068-013-0107-8

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