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Linking physical activity with clinical, functional, and structural outcomes: an evidence map using the Osteoarthritis Initiative

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Abstract

Physical activity is consistently recommended across clinical practice guidelines for managing knee osteoarthritis, yet prescription rates are low. Evidence mapping uses a systematic approach to visually illustrate and summarize published evidence, highlight gaps in the literature, and formulate research questions. The purpose of this study was to review and summarize evidence published from the Osteoarthritis Initiative (OAI) linking physical activity with clinical, functional, and structural knee osteoarthritis outcomes. Electronic databases were searched until June 2021. Studies from the OAI reporting subjective (Physical Activity Scale for the Elderly, PASE) or objective (accelerometry) physical activity data were included. Scatter plots were created to represent each outcome group (clinical, functional, structural) and physical activity measure (PASE, accelerometry) to map the evidence by the directional effect (positive, interaction, negative, or no effect) associated with physical activity. Forty-two articles were included in this review. Physical activity was quantified using PASE (n = 21), accelerometry (n = 20), or both (n = 1). Studies reported consistently positive physical activity effects on clinical (n = 22) and functional (n = 20) outcomes, with few exceptions. Structural (n = 15) outcomes were largely reported as interaction effects by physical activity intensity or sex, or as no significant effect. A network of interconnected outcomes emerged, with clinical and functional outcomes often reported together, and structural outcomes reported individually. This study provides an overview of current evidence linking physical activity to multiple interrelated knee osteoarthritis outcomes using an OAI-driven model. These evidence maps can be used as a framework to guide future investigations of the effects of physical activity on knee osteoarthritis.

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Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

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Acknowledgements

The authors would like to thank the Osteoarthritis Initiative (OAI) participants, and the study investigators and coordinators at each of the four sites. The OAI is a data repository housed within the NIMH Data Archive (NDA). The OAI is a collaborative informatics system created by the National Institute of Mental Health and the National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS) to provide a worldwide resource to quicken the pace of biomarker identification, scientific investigation and OA drug development. OAI data are available in a public, open access repository (https://nda.nih.gov/oai).

Funding

Aleksandra R. Budarick was supported by a Nova Scotia Research and Innovation Graduate Scholarship, a Scotia Scholars Award (Research Nova Scotia), an MSSU Student Award (Maritime SPOR SUPPORT Unit), and a Killam Level II Predoctoral Scholarship.

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Authors and Affiliations

  1. School of Physiotherapy, Dalhousie University, Forrest Building, 5869 University Avenue, NS, B3H 4R2, Halifax, Canada

    Aleksandra R. Budarick & Rebecca F. Moyer

  2. Dynamics of Human Motion Laboratory, Dalhousie University, Halifax, NS, Canada

    Aleksandra R. Budarick & Rebecca F. Moyer

  3. Laboratory for Clinical Biomechanics and Rehabilitation, Dalhousie University, Halifax, NS, Canada

    Aleksandra R. Budarick & Rebecca F. Moyer

Authors
  1. Aleksandra R. Budarick
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  2. Rebecca F. Moyer
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Contributions

ARB: Conceptualization, investigation, data curation, writing original draft, review and editing, visualization. RFM: Conceptualization, review and editing, supervision.

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Correspondence to Rebecca F. Moyer.

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Part of this manuscript has been previously published as an abstract in conference proceedings [1].

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Budarick, A.R., Moyer, R.F. Linking physical activity with clinical, functional, and structural outcomes: an evidence map using the Osteoarthritis Initiative. Clin Rheumatol 41, 965–975 (2022). https://doi.org/10.1007/s10067-021-05995-y

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  • DOI: https://doi.org/10.1007/s10067-021-05995-y

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