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The clinical phenotype of patients positive for antibodies to myositis and myositis-related disorders

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Abstract

Inflammatory myopathies are a clinically diverse group of diseases, in which the detection of particular autoantibodies may facilitate diagnosis, treatment, and prognosis. The aim of this report is to summarize our experience with specific autoantibody testing in patients with inflammatory myopathies. Data were collected over the last decade in the Autoimmune Center of the Sheba Medical Center, a tertiary referral hospital. Data regarding patients’ positive for autoantibodies against Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, and PM-Scl antigens were retrospectively collected. Patient demographics, clinical characteristics, and mortality were recorded. Descriptive statistics (mean, standard deviation, frequency, and percentage) were calculated. A total of 507 patients were surveyed for sclero-poly-synthetase antibodies, as part of the diagnostic workup of myositis/myalgia or interstitial lung disease. Forty-three patients were found positive for one or more of the abovementioned antibodies, and 23 of them (53.49%) had interstitial lung disease (ILD). Four patients were positive for anti-PL-7, three of them had ILD and Raynaud’s phenomenon. Five patients were positive for anti-Ku, and four of them had both arthritis and Raynaud’s phenomenon. Nine patients were positive for anti-Mi-2, and six of them were given diagnosed with dermatomyositis. Ten patients were positive for anti-SRP, and six of them had cancers of various types. Our results reiterate the previously recognized associations between anti-Mi-2 and dermatomyositis, anti-Ku and Raynaud’s phenomenon, and between anti-PL-7 and ILD. In addition, our data support an association between anti-SRP autoantibody positivity and malignancy, which calls for further investigation.

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Acknowledgments

The authors thank Jacqueline Wyatt for her contribution in editing and proofreading of this manuscript.

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Author notes

  1. S. G. Gofrit and H. Yonath contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine A, Sheba Medical Center, 5262000, Tel Hashomer, Israel

    S. G. Gofrit, H. Yonath & S. Kivity

  2. Danek Gertner Institute of Human Genetics, Tel Hashomer, Israel

    H. Yonath

  3. Sackler School of Medicine, Ramat Aviv, Israel

    H. Yonath, M. Lidar, Y. Shoenfeld & S. Kivity

  4. The Zabludowicz Center for Autoimmune Diseases, Tel-Hashomer, Israel

    M. Lidar, Y. Shoenfeld & S. Kivity

  5. Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel

    Y. Shoenfeld

  6. The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013 and Sheba Medical Center, Tel-Hashomer, Israel

    S. Kivity

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  1. S. G. Gofrit
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Correspondence to S. Kivity.

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Gofrit, S.G., Yonath, H., Lidar, M. et al. The clinical phenotype of patients positive for antibodies to myositis and myositis-related disorders. Clin Rheumatol 37, 1257–1263 (2018). https://doi.org/10.1007/s10067-018-4032-3

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  • DOI: https://doi.org/10.1007/s10067-018-4032-3

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