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The effect of resveratrol on the recurrent attacks of gouty arthritis

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Abstract

Gouty arthritis is characterized by inflammation induced by monosodium urate (MSU) crystal deposition, which is resulted by an increase of serum urate concentration. The management of gout, especially the recurrent acute attacks of chronic gouty arthritis, is still a problem to be resolved. In this study, we aimed to develop the preventive and therapeutic effect of resveratrol on gouty arthritis. MSU was used to induce gouty arthritis in the foot pad of C57BL/6 mice. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in Kunming mice. Resveratrol was intraperitoneal injected to the mice in the treatment group. The pad inflammation and the level of serum uric acid were investigated to estimate the effect of resveratrol in gouty arthritis. Hyperuricemia was significantly detected in the mice treated with yeast polysaccharide and potassium oxonate, and gouty arthritis was successfully induced with MSU in mice. We further identified that resveratrol inhibited pad swelling and pad 99mTc uptake in gouty mice. Moreover, serum uric acid level was also decreased by resveratrol in hyperuricemia mice. This study highlighted that resveratrol might be applied to prevent the recurrent acute attack of gouty arthritis because of its inhibition of articular inflammation and down-regulation of serum uric acid.

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Acknowledgments

This work was supported by the Major Project of Shanghai Science and Technology Foundation (NO. 11DJ1400101) and the National Natural Science Foundation of China (No. 81302573). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Division of Rheumatology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040

    Haiyan Chen, Shucong Zheng, Yu Xue, Hejian Zou & Xiaoxia Zhu

  2. Institute of Rheumatology, Immunology and Allergy, Shanghai Medical College, Fudan University, 12 Wulumuqizhong Road, Shanghai, China, 200040

    Haiyan Chen, Shucong Zheng, Yu Xue, Hejian Zou & Xiaoxia Zhu

  3. Division of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, 200040

    Yuankai Wang & Huiqing Zhu

  4. Department of Human Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai, China, 200032

    Qiong Liu

  5. Department of Emergency Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, 02129, USA

    Jianhua Qiu

  6. Division of Rheumatology, Zhongda Hospital, Dongnan University, Nanjing, China

    Haiyan Chen

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  1. Haiyan Chen
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  2. Shucong Zheng
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  5. Qiong Liu
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  7. Jianhua Qiu
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  8. Hejian Zou
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  9. Xiaoxia Zhu
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Correspondence to Xiaoxia Zhu.

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Haiyan Chen and Shucong Zheng contributed equally to this paper

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Chen, H., Zheng, S., Wang, Y. et al. The effect of resveratrol on the recurrent attacks of gouty arthritis. Clin Rheumatol 35, 1189–1195 (2016). https://doi.org/10.1007/s10067-014-2836-3

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  • DOI: https://doi.org/10.1007/s10067-014-2836-3

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