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Acute hepatitis in adult Still’s disease during corticosteroid treatment successfully treated with anakinra

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Abstract

Adult onset Still’s disease (AOSD) is a well-recognized clinical disorder characterized by involvement of various organs, including liver. However, acute hepatitis or hepatic failure is extremely rare, and most of the reported cases occurred during treatment with hepatotoxic drugs. Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Experimental and clinical data support a central role for IL-1Ra in fulminant hepatic failure. We report the case of a patient with AOSD complicated with acute hepatitis during treatment with corticosteroids, which was dramatically improved with anakinra.

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Authors and Affiliations

  1. 5th Department of Internal Medicine, Evangelismos Hospital, 45–47 Hipsilantou Str., Kolonaki, 106 76, Athens, Greece

    Eleni Mylona, Styliani Golfinopoulou, Michael Samarkos, Panagiotis Fanourgiakis & Athanasios Skoutelis

  2. Department of Rheumatology, Evangelismos Hospital, Athens, Greece

    Vasilios Papadakos

Authors
  1. Eleni Mylona
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  2. Styliani Golfinopoulou
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  3. Michael Samarkos
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  4. Panagiotis Fanourgiakis
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  5. Vasilios Papadakos
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  6. Athanasios Skoutelis
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Correspondence to Eleni Mylona.

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Mylona, E., Golfinopoulou, S., Samarkos, M. et al. Acute hepatitis in adult Still’s disease during corticosteroid treatment successfully treated with anakinra. Clin Rheumatol 27, 659–661 (2008). https://doi.org/10.1007/s10067-007-0791-y

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  • DOI: https://doi.org/10.1007/s10067-007-0791-y

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