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Endocarditis associated with antineutrophil cytoplasmic antibodies: a case report and review of the literature

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Abstract

We report a case of subacute bacterial endocarditis associated with small vessel vasculitis and a strongly positive cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA) test. It is important to recognize this cause of positive c-ANCA because infectious endocarditis may closely mimic the clinical manifestations of ANCA-associated vasculitides such as Wegener granulomatosis or microscopic polyangiitis. Furthermore, ANCA-associated vasculitis may result in noninfectious endocarditis, which may be confused with bacterial endocarditis. In this paper, we review reported cases of ANCA-positive bacterial endocarditis and compare them to the reported cases of ANCA-associated idiopathic vasculitis with endocardial compromise.

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Fig. 1

Abbreviations

ANCA:

Antineutrophil cytoplasmic antibodies

c-ANCA:

Cytoplasmic antineutrophil cytoplasmic antibodies

p-ANCA:

Perinuclear antineutrophil cytoplasmic antibodies

SBE:

Subacute bacterial endocarditis

SVV:

Small vessel vasculitis

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Author notes

  1. Julio A. Chirinos

    Present address: VAMC-Cardiology (111-A), 1201 NW 16th Street, Miami, 33125, FL, USA

Authors and Affiliations

  1. Department of Medicine, University of Miami, School of Medicine and Veterans Affairs Medical Center, Miami, FL, USA

    Julio A. Chirinos, Vicente F. Corrales-Medina, Santiago Garcia, Daniel M. Lichtstein, Alan L. Bisno & Simon Chakko

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  1. Julio A. Chirinos
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  2. Vicente F. Corrales-Medina
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  3. Santiago Garcia
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  4. Daniel M. Lichtstein
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  5. Alan L. Bisno
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  6. Simon Chakko
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Corresponding author

Correspondence to Julio A. Chirinos.

Additional information

Julio A. Chirinos and Vicente F. Corrales-Medina contributed equally in the preparation of this manuscrip

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Chirinos, J.A., Corrales-Medina, V.F., Garcia, S. et al. Endocarditis associated with antineutrophil cytoplasmic antibodies: a case report and review of the literature. Clin Rheumatol 26, 590–595 (2007). https://doi.org/10.1007/s10067-005-0176-z

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  • DOI: https://doi.org/10.1007/s10067-005-0176-z

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