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Validation of the Spanish version of a screening questionnaire for the detection of systemic lupus erythematosus

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Abstract

the aim of this study was to assess the sensitivity, specificity, positive and negative predictive values of the translation of a screening questionnaire for systemic lupus erythematosus (SLE) in Spanish-speaking populations. The questionnaire was applied to secondary-care outpatients in a rheumatology clinic. Sensitivity, specificity, predictive positive and negative values of the instrument, and the best cut-off point to discriminate between SLE patients and other conditions, were determined. Fifty-two subjects answered the questionnaire (21 patients with SLE, 15 with a possible diagnosis of SLE who eventually proved not to have the disease, and 16 healthy volunteers), which can be answered in 2 min. The best cut-off point was three affirmative answers (95% specificity, 84% sensitivity, 80% predictive positive and 96% predictive negative values). The questionnaire can discriminate between SLE cases and other conditions. Sensitivity and specificity are close to those of the original English version. Applying this instrument can help to acquire informed estimates of SLE prevalence.

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Abbreviations

ANA:

Antinuclear antibody

NPV:

Negative predictive value

PPV:

Positive predictive value

SLE:

Systemic lupus erythematosus

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Authors and Affiliations

  1. Hospital General Regional No. 46, Instituto Mexicano del Seguro Social, Col. Chapalita Campo de Polo, La Merced 1025, CP 45050, Jalisco, México, Guadalajara

    Francisco Javier Aceves-Avila

  2. Unidad de Investigación en Enfermedades Crónico-Degenerativas SC, Jalisco, Mexico, Guadalajara

    Francisco Javier Aceves-Avila, Martha Alicia Delgadillo-Ruano, César Ramos-Remus, Amparo Gómez-Vargas & Sergio Gutiérrez-Ureña

  3. Department of Rheumatology, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, Guadalajara

    César Ramos-Remus

  4. Unidad de Investigación en Reumatología, URHIA, Antiguo Hospital Civil de Guadalajara , Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Jalisco, Mexico, Guadalajara

    Sergio Gutiérrez-Ureña

Authors
  1. Francisco Javier Aceves-Avila
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  2. Martha Alicia Delgadillo-Ruano
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  3. César Ramos-Remus
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  4. Amparo Gómez-Vargas
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  5. Sergio Gutiérrez-Ureña
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Correspondence to Francisco Javier Aceves-Avila.

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Aceves-Avila, F.J., Delgadillo-Ruano, M.A., Ramos-Remus, C. et al. Validation of the Spanish version of a screening questionnaire for the detection of systemic lupus erythematosus. Clin Rheumatol 22, 400–404 (2003). https://doi.org/10.1007/s10067-003-0767-5

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  • DOI: https://doi.org/10.1007/s10067-003-0767-5

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