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Multiple-Scattering-Free Optical Glucose Monitoring Based on Femtosecond Pulse Interferometry

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Abstract

We have designed a novel multiple-scattering-free optical glucose monitoring system based on femtosecond pulse interferometry. The glucose concentration is determined by a time-of-flight method, while multiple-scattering light is rejected by a coherence gate. The resultant accuracy and precision were 94.7 and 24.5 mg/dl, respectively, for physiological-equivalent glucose concentrations in a scattering medium of 1.0% intralipid solution, while the accuracy and precision for a reference sample containing no scattering medium were 65.3 and 23.8 mg/dl, respectively. Comparing these results, we conclude that the proposed method is effective for glucose measurement in a scattering medium.

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Authors and Affiliations

  1. Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan

    Yasuaki Hori, Takeshi Yasui & Tsutomu Araki

Authors
  1. Yasuaki Hori
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  2. Takeshi Yasui
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  3. Tsutomu Araki
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Hori, Y., Yasui, T. & Araki, T. Multiple-Scattering-Free Optical Glucose Monitoring Based on Femtosecond Pulse Interferometry. OPT REV 12, 202–206 (2005). https://doi.org/10.1007/s10043-005-0202-z

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  • DOI: https://doi.org/10.1007/s10043-005-0202-z

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