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Hernia disease and collagen gene regulation: are there clues for intervention?

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Abstract

Collagens belong to the most abundant proteins in the body. After tissue injury, a coordinated regulation of collagen gene expression guides the formation of a provisional matrix that subsequently evolves into a mature scar with tensile strength. In the following, knowledge regarding collagen gene regulation that may provide insight into how to specifically address the biological problem of soft tissue weakness and recurrent hernia disease is summarized.

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Acknowledgments

This work was supported by the Deutsche Forschungsgemeinschaft, DFG grant KL 1320/2-1 (U.K., P.R.M.) and JA 1123/1-1 (P.L.J., U.K., P.R.M., M.J.).

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Authors and Affiliations

  1. Interdisciplinary Center for Clinical Research BIOMAT, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen, 52074, Germany

    Petra Lynen Jansen

  2. Department of Surgery, University Hospital, RWTH Aachen, Aachen, 52074, Germany

    Uwe Klinge

  3. Department of Nephrology and Clinical Immunology, University Hospital, RWTH Aachen, Aachen, 52074, Germany

    Peter R. Mertens

Authors
  1. Petra Lynen Jansen
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  2. Uwe Klinge
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  3. Peter R. Mertens
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Correspondence to Petra Lynen Jansen.

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Lynen Jansen, P., Klinge, U. & Mertens, P.R. Hernia disease and collagen gene regulation: are there clues for intervention?. Hernia 10, 486–491 (2006). https://doi.org/10.1007/s10029-006-0147-6

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  • DOI: https://doi.org/10.1007/s10029-006-0147-6

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