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Microcomputed tomographic analysis of bone microarchitecture after sinus augmentation with hyaluronic matrix: a case–control study

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Abstract

Background

The aim of this study was to analyze trabecular microarchitecture of augmented sinuses with hyaluronic matrix and xenograft by microcomputed tomography, and to investigate whether hyaluronic matrix has an effect on the newly formed bone quality.

Materials and methods

Thirteen patients undergoing maxillary sinus augmentation were included in this split-mouth study. Right and left sinus sites were randomly assigned to test and control group. In test group, the sinus was grafted with hyaluronic matrix and xenograft; in control group, only with xenograft. Four months after augmentation, bone samples were harvested during implant placement and analyzed for the following trabecular microarchitecture parameters using microcomputed tomography: bone volume (BV), total volume (TV), bone volume fraction (BV/TV), bone surface (BS), specific bone surface (BS/BV), bone surface density (BS/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular pattern factor (Tb.Pf), and fractal dimension (FD).

Results

There was statistically significant difference only for BS/TV parameter between two groups. BS/TV was higher in hyaluronic matrix group compared with control group.

Conclusions

Addition of hyaluronic matrix to xenograft may enhance bone quality in terms of bone surface density. However, more research investigating the microstructural variation of augmented sinuses is needed with a greater sample.

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Abbreviations

CHBG:

Collagenated heterologous bone graft

HA:

Hyaluronic acid

3D:

Three dimensional

MicroCT:

Microcomputed tomography

ROI:

Region of interest

BV:

Bone volume

TV:

Total volume

BV/TV:

Bone volume fraction

BS:

Bone surface

BS/BV:

Specific bone surface

BS/TV:

Bone surface density

Tb.Th:

Trabecular thickness

Tb.Sp:

Trabecular separation

Tb.Pf:

Trabecular pattern factor

FD:

Fractal dimension

HR-MRI:

High-resolution magnetic resonance imaging

HR-pQCT:

High-resolution peripheral quantitative computed tomography

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Funding

This work was supported by Hacettepe University, Scientific Research Projects Coordination Unit [grant number THD-2015–5190].

Author information

Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Kutahya Health Sciences University, 43100, Kutahya, Turkey

    Ezgi Gurbuz

  2. Private Practice in Periodontology, Ankara, Turkey

    Erhan Dursun

  3. Department of Anatomy, Faculty of Medicine, Balıkesir University, Balıkesir, Turkey

    Alper Vatansever

  4. Department of Periodontology, Faculty of Dentistry, Hacettepe University, Sıhhiye, 06100, Ankara, Turkey

    Feriha Caglayan

Authors
  1. Ezgi Gurbuz
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  2. Erhan Dursun
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  3. Alper Vatansever
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Corresponding author

Correspondence to Ezgi Gurbuz.

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Ethical approval

Approval was obtained from Clinical Researches Ethics Board of Hacettepe University (2014/08—16 (KA-14030)). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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The authors declare no competing interests.

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Gurbuz, E., Dursun, E., Vatansever, A. et al. Microcomputed tomographic analysis of bone microarchitecture after sinus augmentation with hyaluronic matrix: a case–control study. Oral Maxillofac Surg 26, 431–437 (2022). https://doi.org/10.1007/s10006-021-01002-5

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