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Histopathological changes of myocytes in restrictive cardiomyopathy

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Abstract

Restrictive cardiomyopathy (RCM) is a rare primary myocardial disease, and its pathological features are yet to be determined. Restrictive cardiomyopathy with MHY7 mutation was diagnosed in a 65-year-old Japanese woman. Electron microscopy of a myocardial biopsy revealed electron-dense materials resulting from focal myocyte degeneration and necrosis as well as tubular structures and pseudo-inclusion bodies in some nuclei. These features may be associated with the pathogenesis of RCM.

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Abbreviations

RCM:

Restrictive cardiomyopathy

HCM:

Hypertrophic cardiomyopathy

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Acknowledgements

None.

Funding

This work was supported by the Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research, Grant Number 17K09512.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Hiroaki Kawano, Mitsuaki Ishijima & Koji Maemura

  2. Faculty of Science and Engineering, Waseda University, Tokyo, Japan

    Koichi Kawamura

  3. Department of Cardiology, Juzenkai Hospital, Nagasaki, Japan

    Munetake Kanda

  4. Department of Pathology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan

    Kuniko Abe

  5. Department of Pathology, Shimabara Prefectural Hospital, Shimabara, Japan

    Tomayoshi Hayashi

  6. Department of Cardiology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan

    Yuji Matsumoto

  7. Department of Molecular Pathogenesis, Medical Research Institute Tokyo Medical and Dental University, Tokyo, Japan

    Akinori Kimura

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  1. Hiroaki Kawano
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Correspondence to Hiroaki Kawano.

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Kawano, H., Kawamura, K., Kanda, M. et al. Histopathological changes of myocytes in restrictive cardiomyopathy. Med Mol Morphol 54, 289–295 (2021). https://doi.org/10.1007/s00795-021-00293-7

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  • DOI: https://doi.org/10.1007/s00795-021-00293-7

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