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Oral lymphoid lesions: a 47-year clinicopathological study in a Brazilian population

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Abstract

We performed an epidemiological, clinical and histopathological analysis of oral lymphoid lesions (OLLs) during a 47-year period. Data regarding patient age, sex, duration, location, symptomatology, type of growth, implantation, staining, presence of ulceration and bleeding of all cases were compiled from the clinical data. For the histopathological analyses, all slides stained by H/E were reassessed. During the analyzed period, 14,565 patients with oral and maxillofacial lesions were diagnosed, with 45 cases diagnosed as OLLs. The most prevalent location was the tongue. Females were more affected, and the mean age was 40.8 years. OLLs presented a heterogeneous frequency, with the prevalence of reactive lesions (42.3%) followed by developmental lesions (35.6%). Among the reactive lesions, foreign body granulomas were the most common. Regarding diagnosed neoplasms, malignant represented 13.2% of the cases. The average time of evolution of OLLs in general was of 22.2 months. Regarding the histopathological characteristics, the presence of primary lymphoid follicles was observed in 37.8% of the cases, while inflammatory infiltrates were diffuse in 66.7% and epimyoepithelial islands were observed in 13.3%. Our study concludes that OLLs involves a broad spectrum of lesions that share the presence of the lymphoid component, which can range from indolent to more aggressive behavior.

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Funding

The work was supported by Oral Pathology Post-Graduation Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

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Authors and Affiliations

  1. Oral Pathology Post-Graduation Program Student, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Juliana Campos Pinheiro, Caio César da Silva Barros & Larissa Santos Amaral Rolim

  2. Oral Pathology Post-Graduation Program, Dentistry Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Leão Pereira Pinto & Lélia Batista de Souza

  3. Oral Pathology Post-Graduation Program, Morphology Department, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Pedro Paulo de Andrade Santos

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  1. Juliana Campos Pinheiro
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  2. Caio César da Silva Barros
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Correspondence to Pedro Paulo de Andrade Santos.

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The author Juliana Campos Pinheiro declares that he has no conflict of interest; author Caio César da Silva Barros declares that he has no conflict of interest; author Larissa Santos Amaral Rolim declares that he has no conflict of interest; author Leão Pereira Pinto declares that he has no conflict of interest; author Lélia Batista de Souza declares that he has no conflict of interest; author Pedro Paulo de Andrade Santos declares that he has no conflict of interest.

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Pinheiro, J.C., da Silva Barros, C.C., Rolim, L.S.A. et al. Oral lymphoid lesions: a 47-year clinicopathological study in a Brazilian population. Med Mol Morphol 52, 123–134 (2019). https://doi.org/10.1007/s00795-018-0210-2

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