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Abnormal response to emotional stimulus in male adolescents with violent behavior in China

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Abstract

The objective of the study is to explore the characteristics of emotional stimulus in adolescents with violent behavior and to identify the correlated dysfunctional regions of the brain. An event-related functional magnetic resonance imaging was obtained while the participants passively viewed pictures with neutral or negative affective valence. 15 male adolescents with violent behavior, ranging in age from 12 to 18 years old, and 16 healthy age-matched control subjects were enrolled in the study. While looking at neutral pictures, several brain regions were activated more intensely in the violent group than the control one. After digitally subtracting the control group, these areas included the bilateral amygdala, left orbital gyrus, bilateral fusiform gyrus, and left visual cortex. While passively viewing negative pictures, the right inferior frontal gyrus and the middle frontal gyrus were less activated in the violent group than the control group. Male adolescents with violent behaviors have some dysfunctions during the processing and evaluation of information from external emotional stimulus. These individuals are inclined to interpret neutral information as threatening stimulus.

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Acknowledgments

This work was partially supported by “the National Science & Technology Pillar Program during the 11th Five-Year Plan of China” grant (2007BAI17B03, PI: Bin Xie), Shanghai Municipal Health Bureau Research Funding grant (2006064, PI: Bin Xie) and Shanghai Municipal Health Bureau Youth Research Funding grant (2010Y056, PI: Yi Qiao). This research was also supported by the Opening Project of Shanghai Key Laboratory of Magnetic Resonance.

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Authors and Affiliations

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China

    Yi Qiao & Bin Xie

  2. Shanghai Key laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai, 200062, China

    Xiaoxia Du

Authors
  1. Yi Qiao
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  2. Bin Xie
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  3. Xiaoxia Du
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Corresponding author

Correspondence to Bin Xie.

Additional information

Y. Qiao, B. Xie and X. Du contributed equally to the manuscript.

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Qiao, Y., Xie, B. & Du, X. Abnormal response to emotional stimulus in male adolescents with violent behavior in China. Eur Child Adolesc Psychiatry 21, 193–198 (2012). https://doi.org/10.1007/s00787-012-0252-2

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  • DOI: https://doi.org/10.1007/s00787-012-0252-2

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