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Comparative analysis of the effect of self-assembling peptide P11-4 on enamel erosion: a confocal laser scanning microscopy study

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Abstract

Objectives

This study aims to comparatively assess the preventive and protective effects of the self-assembling peptide P11-4 on enamel erosion and evaluate the potential for enamel surface recovery when professional products are combined with home-use dental-care products during the erosive process.

Materials and methods

Ninety-nine bovine incisors were divided into nine groups: a control group, four groups with the application of professional-products [P11-4 peptide (Curodont-Repair), stannous/Sn2+ containing solution (8% Sn2+), casein-phosphopeptide-amorphous-calcium-phosphate fluoride/CPP-ACPF (MI Varnish), sodium fluoride/NaF (Profluorid)] and four groups with the combination of professional products and home-use daily dental care products [P11-4 peptide (Curodont Repair + Curodont Protect), stannous ions containing agents (8% Sn2++Emofluor Gel Intensive-Care), CPP-ACPF (MI Varnish + MI Paste Plus), NaF (Profluorid + ReminPro)].

Professional products were applied once before a five-day erosive cycle, involving six 2-minute citric-acid exposures per day. In combined-groups, a home-use dental-care product was applied daily at the end of each cycle day. After the cycle, lesion depth and fluorescence were analyzed using confocal-laser-scanning-microscopy, and results were statistically evaluated using paired t-tests, ANOVA, and Tukey’s post-hoc tests.

Results

The P11-4 group was significantly more effective among the professional-only groups in both parameters (p<0.001). All combined-groups were determined to be statistically more successful than their respective professional-groups in both parameters (p<0.05). Based on lesion depth data, it was observed that the P11-4 and stannous-containing combined-groups showed statistically similar results (p>0.05). In terms of lesion fluorescence data, the P11-4 combined-group was found to be statistically more successful than all other study groups (p<0.05).

Conclusion

The self-assembling peptide P11-4 was determined to exhibit the best preventive and protective anti-erosive effect in both professional and combined applications.

Clinical Relevance

A positive relationship was observed between the support of professional applications with home-use daily-dental-care products and protection against erosive lesions.

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Data availability

No datasets were generated or analysed during the current study.

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Acknowledgements

This study was supported by the Izmir Katip Celebi University Scientific Research Projects Coordination Unit (Project number: 2022-GAP-DİSF-0047).

Funding

This project was supported by the Scientific Research Projects Coordination Unıt of the Izmir Katip Celebi University.

Project Number: 2022-GAP-DİSF-0047.

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Authors and Affiliations

  1. Department of Pedodontics, Faculty of Dentistry, Uskudar University, Istanbul, Turkey

    Buse Yilmaz Sen

  2. Department of Pedodontics, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey

    Merve Akcay

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MA: conceptualization, literature review, methodology, writing-original draft preparation, data analysis, review-writing and editing BYS: literature review, methodology, application, writing, data analysis, review-writing and editing.

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Yilmaz Sen, B., Akcay, M. Comparative analysis of the effect of self-assembling peptide P11-4 on enamel erosion: a confocal laser scanning microscopy study. Clin Oral Invest 29, 29 (2025). https://doi.org/10.1007/s00784-024-06115-1

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