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Alveolar ridge splitting and simvastatin loaded xenograft for guided bone regeneration and simultaneous implant placement: randomized controlled clinical trial

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Abstract

Objectives

The present study goal was to assess clinically and radiographically using simvastatin (SMV) loaded xenograft for guided bone regeneration (GBR) around simultaneously placed implants with alveolar ridge splitting in patients with horizontally atrophic jaw defect.

Materials and methods

Randomized distribution of the twenty-two patients into two groups (11 patients each) was performed. Group I participants received alveolar ride splitting (ARS) with GBR using SMV gel mixed bone graft and a barrier membrane with simultaneous implant placement. Group II received the same treatment protocol without SMV gel. At the baseline, 6- and 9-months post-surgery, clinical and radiological alterations were assessed.

Results

Six months after therapy, PES records of group I were statistically significantly improved than those of group II (P < .001). Group I exhibited statistically significant expansion of the alveolar ridge over group II after 6 and 9 months (P < .001). When compared to group II over the evaluation interval between 6 and 9 months, group I demonstrated statistically substantially minimal loss of the mean marginal bone level (P < .001). At the 6- and 9-month observation periods, bone density gain was considerably higher in group I than that in group II (P < .001).

Conclusion

Alveolar ridge splitting along with GBR-augmented SMV improve the clinical and radiographical outcomes around dental implant over GBR alone.

Clinical relevance

Augmenting GBR with SMV in alveolar ridge splitting could boost implant osseointegration and enhance peri-implant tissue changes.

Clinical trial registration: NCT05020405.

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Data availability

The data are available upon request from the corresponding author.

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Author notes

  1. Dalia Rasheed Issa

    Present address: Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA

Authors and Affiliations

  1. Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Kafrelsheikh University, Kafr El-Sheikh, Egypt

    Dalia Rasheed Issa & Walid Elamrousy

  2. Department of Periodontology, Faculty of Oral and Dental Medicine, Ain Shams University-Misr University for Science and Technology, Cairo, Egypt

    Ahmed Y. Gamal

Authors
  1. Dalia Rasheed Issa
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  2. Walid Elamrousy
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Contributions

Dalia Rasheed Issa and Ahmed Y. Gamal conceived the idea; Walid Elamrousy performed the surgeries; Dalia Rasheed Issa and Walid Elamrousy analyzed the data; and Dalia Rasheed Issa and Ahmed Y. Gamal led the writing.

All authors read and approved the final manuscript.

Corresponding author

Correspondence to Dalia Rasheed Issa.

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Ethical approval

The present study has been approved by the Research Ethics Committee of Kafrelsheikh University, Egypt (KFSIRB200-22). The investigation was conducted according to the revised principles of the Helsinki Declaration.

Consent to participate

Research procedures were explained to all patients, and they agreed to participate in the study and signed the appropriate informed consent form before beginning of the study.

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The authors declare no competing interests.

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Issa, D.R., Elamrousy, W. & Gamal, A.Y. Alveolar ridge splitting and simvastatin loaded xenograft for guided bone regeneration and simultaneous implant placement: randomized controlled clinical trial. Clin Oral Invest 28, 71 (2024). https://doi.org/10.1007/s00784-023-05427-y

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