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Effect of different retreatment files using different kinematics on the release of inflammatory mediators in root canal retreatment of single-rooted teeth: a randomized clinical trial

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A Correction to this article was published on 11 March 2023

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Abstract

Objectives

This randomized clinical trial aimed to evaluate the effect of two rotaries (ProTaper Universal Retreatment (PTUR)), D-Race (DR) + XP-Endo Finisher R (XPFR) and one reciprocating (Reciproc Blue (RB) retreatment techniques on the release of neuropeptides (Substance P, calcitonin gene-related peptide (CGRP)), and cytokines (IL-6 and IL-10) in periapical fluid in root canal retreatment of single-rooted teeth.

Materials and methods

In this randomized clinical trial (ClinicalTrials.gov ID: NCT05039502), seventy-five patients scheduled for retreatment were randomly divided into 3 groups according to the file system used to remove root canal filling materials (n = 25): PTUR, RB, and DR + XPFR. After reshaping and disinfection of the root canals, periapical fluid samples were taken, and the levels of Substance P, CGRP, IL-6, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA) test. Data were analyzed using the Kruskal–Wallis and chi-square tests. The level of significance was set as p = 0. 05.

Results

All the allocated participants received the intervention and were analyzed. There was no statistically significant difference among groups in terms of gender, age, tooth localization, and the distribution of analgesic use after treatment (p values 0.799, 0.095, 0.637, 1.000, respectively). No statistically significant difference was found in terms of the levels of Substance P, CGRP, and IL-10 among groups (p > .05), except IL-6.

Conclusions

PTUR, RB, and DR + XPFR files have comparable results in the expression of inflammatory mediators.

Clinical relevance

Retreatment files powered with rotary or reciprocating motion produced similar neuropeptide and cytokine levels in patients.

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Funding

This study was supported by the Scientific Research and Development Department of Zonguldak Bülent Ecevit University (grant number: 2020–27194235-01).

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Authors and Affiliations

  1. Department of Endodontics, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey

    Sena Kaşıkçı

  2. Department of Endodontics, Faculty of Dentistry, Zonguldak Bülent Ecevit University, Zonguldak, Turkey

    Sevinç Aktemur Türker

  3. Department of Biochemistry, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Turkey

    Berrak Güven

Authors
  1. Sena Kaşıkçı
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  2. Sevinç Aktemur Türker
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  3. Berrak Güven
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Contributions

Conceptualization: Sena Kaşıkçı, Sevinç Aktemur Türker, Berrak Güven. Methodology: Sena Kaşıkçı, Sevinç Aktemur Türker. Formal analysis and investigation: Sena Kaşıkçı, Berrak Güven. Writing—original draft preparation: Sena Kaşıkçı. Writing—review and editing: Sevinç Aktemur Türker. Supervision: Sevinç Aktemur Türker, Berrak Güven.

Corresponding author

Correspondence to Sevinç Aktemur Türker.

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Ethical approval

This study was approved by the clinical trials ethics committee of the Medicines and Medical Devices Agency of the Ministry of Health with the study number 2019–204.

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Written informed consent was obtained from all patients to participate in the study.

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The authors declare no competing interests.

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The original version of this article was revised: This article was originally published with a mistake p value for IL-6 in table 2. The correct p value is 0.024.

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Kaşıkçı, S., Türker, S.A. & Güven, B. Effect of different retreatment files using different kinematics on the release of inflammatory mediators in root canal retreatment of single-rooted teeth: a randomized clinical trial. Clin Oral Invest 27, 3189–3196 (2023). https://doi.org/10.1007/s00784-023-04930-6

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